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MoonDragon's Health & Wellness
Nutrition Basics

Supplements
HYALURONIC ACID
(HA)

Joint Lubricant & Skin Care


For Informational Use Only
For more detailed information contact your health care provider
about options that may be available for your specific situation.





  • Hyaluronic Acid Description
  • Hyaluronic Acid Uses, Health Benefits & Scientific Evidence
  • Hyaluronic Acid Flag Dosage Information
  • Hyaluronic Acid Safety, Cautions & Interactions
  • Hyaluronic Acid Supplement Products




  • hyaluronic acid


    HYALURONIC ACID DESCRIPTION

    Hyaluronic Acid (HA), also known as hyaluronan or hyaluronate, is a carbohydrate, more specifically a mucopolysaccharide occurring naturally throughout the human body. Hyaluronic Acid is a compound present in every tissue of the body, with the highest concentrations occurring in connective tissues such as skin and cartilage.

    Hyaluronic Acid can be several thousands of sugars (carbohydrates) long. When not bound to other molecules, it binds to water giving it a stiff viscous quality similar to "Jello" gelatin. This viscous Gel is one of the most heavily researched substances in medicine today with thousands of trials mostly in the fields of orthopedics and eye surgery. Its function in the body is, amongst other things, to bind water and to lubricate movable parts of the body, such as joints and muscles. Hyaluronic Acid is an important constituent of joint fluid where it serves as a lubricant and plays a role in resisting compressive forces. Its consistency and tissue-friendliness allows it to be beneficial in skin-care products as an excellent moisturizer. Because HA is one of the most hydrophilic (water-loving) molecules in nature with numerous benefits for the human body it can be described as "nature's moisturizer."

    HYALURONIC ACID CHEMICAL STRUCTURE

    Hyaluronic Acid was first used commercially in 1942 when Endre Balazs applied for a patent to use it as a substitute for egg white in bakery products. Its discovery was very unique. No other molecule had ever been discovered that has such unique properties to the human body. Balazs went on to become the leading expert on HA, and made the majority of discoveries concerning hyaluronic acid benefits.

    Hyaluronic Acid (conjugate base hyaluronate), also called hyaluronan or simply HA, is naturally produced in the human body and is chemically classified as a nonsulfated, anionic Glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. The average 154 pound (70 kg) person has roughly 15 grams of hyaluronan in the body, one-third of which is turned over (degraded and synthesized) every day. It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi apparatus, and can be very large, with its molecular weight often reaching the millions.

    In the body, HA always presents itself as a large high molecular weight molecule. The molecule is made up of a repetitive sequence of two modified simple sugars, one called Glucuronic Acid and the other N-Acetyl-Glucosamine. These compounds are negatively charged and when combined, they repel producing an exceptionally long stretched out molecule of high molecular weight. HA molecules that are long and large in size produce a high viscosity (lubrication) effect which resists compression and allows joints and skin to bear weight.

    BONES, CARTILAGE, JOINTS & HYALURONIC ACID

    Hyaluronic Acid is found in all bones and cartilage structures throughout the body. These structures provide a resilient rigidity to the structure of the human body. HA is found in various forms of cartilage but none more than hyaline cartilage. Hyaline is short for hyaluronic acid. Hyaline cartilage covers the ends of the long bones where bending (articulation) occurs and provides a cushioning effect for the bones. Hyaline cartilage has also been called the "gristle cartilage" because of its resistance to wear and tear. Hyaline cartilage supports the tip of the nose, connects the ribs to the sternum and forms most of the larynx and supporting cartilage of the trachea and bronchial tubes in the lungs.

    Hyaluronic acid is an important component of articular cartilage, where it is present as a coat around each cell, known as chondrocyte. When aggrecan monomers bind to hyaluronan in the presence of hyaluronanic acid and proteoglycan link protein 1 (HAPLN1), large, highly negatively charged aggrecates form. These aggregates imbibe water and are responsible for the resilience of cartilage and it resistance to compression. The molecular weight (size) of hyaluronan in cartilage decreases with age, but the amount increases.

    SYNOVIAL FLUID & HA

    Until the late 1970s, hyaluronic acid was described as a "goo" molecule, an ubiquitous carbohydrate polymer that is part of the extracellular matrix. Joints, such as the wrists, elbows and knees, are surrounded by a membrane called the synovial membrane which forms a capsule around the ends of the two articulating bones. This membrane secretes a liquid called the synovial fluid. Hyaluronic aicd is a major component of the synovial fluid, and was found to increase the viscosity of the fluid. Synovial fluid is a viscous fluid with the consistency of motor oil. Along with lubricin, it is one of the fluid's main lubricating components. It has many functions, but none more than providing the elastic shock absorbing properties of the joint. Its second most important function in the joint is to carry nutrients to the cartilage and to also remove waste from the joint capsule.

    TENDONS, LIGAMENTS, CONNECTIVE TISSUE & HA

    Connective tissue is found everywhere in the body. It does much more than connect body parts. It has many forms and functions. Its major functions include binding, support, protection, and insulation. One such example of connective tissue is the cordlike structures that connect muscle to bone (tendons) and bone to bone (ligaments). In all connective tissue there are three structural elements. They are ground substance (hyaluronic acid), stretchy fibers (collagen and elastin) and a fundamental cell type. Whereas all other primary tissues in the body are composed mainly of living cells, connective tissues are composed largely of a nonliving ground substance, the hyaluronic acid, which separates and cushions the living cells of the connective tissue. The separation and cushioning allow the tissue to bear weight, withstand great tension and endure abuse that no other body tissue could. All of this is made possible because of the presence of the HA and its ability to form the gelatinous ground substance fluid.

    A lubricating role of hyaluronan in muscular connective tissues to enhance the sliding between adjacent tissue layers has been suggested. A particular type of fibroblasts, embedded in dense fascial tissues, has been proposed as being cells specialized for the biosynthesis of the hyaluronan-rich matrix. Their related activity could be involved in regulating the sliding ability between adjacent muscular connective tissues.

    EXTRACELLULAR MATRIX & HYALURONIC ACID

    The extracellular matrix (ECM) is a gelatinous (gel-like) fluid that surrounds almost all living cells and is essential to life. It gives structure and support to the body and without it, we would just be a trillions cells without a shape or function. It is essentially the mortar between the bricks. The skin, bones, cartilage, tendons and ligaments are examples where the ECM is located in the body. The ECM is composed of material (fibrous elements) called elastin and collagen surrounded by a gelatinous substance (Hyaluronic Acid). HA's roles in the ECM is to help the stretchy fibers in the body from overstretching and drying out by continually bathing them in this nutritious water base gelatinous fluid. It also serves as a wonderful medium through which nutrients and waste are transported to and from the cells of these structures. This fluid would not exist if it was not for the ability of the HA molecule to bind up to 1000 times its weight in water.

    While it is abundant in ECM, hyaluronan contributes to tissue hydrodynamics, movement and proliferation of cells, and participates in a number of cell surface receptor interactions, notably those including its primary receptors, CD44 and RHAMM. Upregulation of CD44 itself is widely accepted as a marker of cell activation in lymphocytes. Hyaluronan's contribution to tumor growth may be due to its interaction with CD44. Receptor CD44 participates in cell adhesion interactions required by tumor cells. Although hyaluronan binds to receptor CD44, there is evidence hyaluronan degradation products transduce their inflammatory signal through toll-like receptor 2 (TLR2), TLR4, or both TLR2 and TLR4 in macrophages and dendritic cells. TLR and hyaluronan play a role in innate immunity. There are limitations including the in vivo loss of this compound limiting the duration of effect.

    SKIN, SCALP TISSUE, HAIR FOLLICLES & HYALURONIC ACID

    Structurally the scalp is identical to the skin tissue located throughout the body except it also contains about 100,000 hair follicles that give rise to hair. Actually the hair and the hair follicle are a derivative of skin tissue. There are two distinctive skin layers, one, the epidermis (outer layer) which gives rise to the protective shield of the body and the other, the dermal layer (deep layer) which makes up the bulk of the skin and is where the hair follicle is located. This dermal layer is composed of connective tissue and the connective tissue, with its gelatinous fluid like characteristics provides support, nourishes and hydrates the deep layers of the scalp. The result is healthy lustrous hair and a moisturized scalp. Again, all of this is made possible because of the presence of HA in the scalp.

    LIPS & HA

    The lips are a core of skeletal muscle covered by skin tissue. The dermal layer of the lips is composed primarily of connective tissue and its components hyaluronic acid and collagen that give the structure (shape) and plumpness to the lips. The HA binds to water creating a gelatinous fluid that hydrates the surrounding tissue and keeps the collagen (responsible for keeping the skin tight) nourished and healthy. The result is healthy well hydrated and plump lips that are well protected from the environment.

    GUM TISSUE & HA

    The Gums (gingivoe) are composed of dense fibrous connective tissue (ligaments) which secure the teeth to the aveloar bone (jaw bone). Once again, connective tissue is composed of a fibrous tissue surrounded by hyaluronic acid (extra-cellular matrix). Without the presence of HA, the gum tissue becomes unhealthy. If it is present it helps to provide the tensile strength of the ligaments that secure the tooth in place by providing hydration and nourishment. The result is a healthy set of gums.

    EYES & HA

    Hyaluronic acid is highly concentrated inside the eyeball. The fluid inside the eye called the vitreous humor is composed almost completely of hyaluronic acid. The HA gives the fluid inside the eye a viscous gel like property. This gel acts as a shock absorber for the eye and also serves to transport nutrients into the eye. HA has been directly injected into the eye during procedures to help maintain the shape of the eye during surgery. It has been said that after the age of 50 years, our eyes stop producing the much needed hyaluronic acid resulting in various eye needs.

    SKIN & HA

    Although Hyaluronic Acid (HA) can be found naturally in most every cell in the body, it is found in the greatest concentrations in the skin tissue. Almost 50-percent of the bodies HA is found here. It is found in both the deep underlying dermal areas as well as the visible epidermal top layers. Young skin is smooth and elastic and contains large amounts of HA that helps keep the skin stay young and healthy. The HA provides continuous moisture to the skin by binding up to 1000 times its weight in water. With age, the ability of the skin to produce HA decreases.

    The skin is the largest organ in the body comprising about 15-percent of the body weight. Roughly 50-percent of the hyaluronic acid in the body is found in the skin. HA and collagen are vital to maintaining the skin's layers and structure. It is the collagen that gives the skin its firmness but it is the HA that nourishes and hydrates the collagen. Imagine the collagen as the stretchy fibers that restore the skin back to shape when stretched. Collagen is like a rubber band but stretch that rubber band a million times, like what we do with our skin and without any moisture. Eventually that rubber band gets overstretched (saggy) and dried out and will most likely break. This is much the same way the collagen in our skin reacts leaving our skin in need of moisture. Now imagine that same rubber band stretched a million times while under water the whole time. Chances of that rubber band drying out and breaking are minimal. Consider the hyaluronic acid as the water that keeps the collagen moist and elastic. Collagen is continuously surrounded and nourished by the gelatinous HA substance. Young skin is smooth and highly elastic because it contains high concentrations of Hyaluronic Acid, which helps skin stay healthy. As we grow older, the body loses its ability to maintain this same concentration in the skin. With decreasing levels of HA in the skin, so goes the ability of the skin to hold water. The result, the skin becomes drier and loses its ability to maintain it's hydration. Hyaluronic acid acts as a space filler by binding to water and thus keeping the skin wrinkle-free.

    Hyaluronic acid is a major component of skin, where it is involved in tissue repair. When skin is exposed to excessive UVB rays, it becomes inflamed (sunburn) and the cells in the dermis stop producing as much hyaluronan, and increase the rate of its degradation. Hyaluronan degradation products then accumulate in the skin after UV exposure.





    HYALURONIC ACID USES, HEALTH BENEFITS, & SCIENTIFIC EVIDENCE

    CANCER

    One of the chief components of the extracellular matrix, hyaluronan contributes significantly to cell proliferation and migration, and may also be involved in the progression of some malignant tumors. Hyaluronic acid is also a component of the group A streptococcal extracellular capsule, and is believed to plaly a role in virulence. In some cancers, hyaluronic acid levels correlate well with malignancy and poor prognosis. Hyaluronic acid is, thus, often used as a tumor marker for prostate and breast cancer. It may also be used to monitor the progression of the disease.

    WOUND REPAIR

    Skin provides a mechanical barrier to the external environment and acts to prevent the ingress of infectious agents. Once injured, the tissues beneath are exposed to infection; therefore, rapid and effective healing is of crucial significance to reconstruct a barrier function. Skin wound healing is a complex process, and includes many interacting processes initiated by haemostasis and the release of platelet-derived factors. The following stages are inflammation, granulation tissue formation, reepithelization and remodeling. HA is likely to play a multifaceted role in mediation of these cellular and matrix events. The proposed roles of HA in this sequence of skin wound healing events are detailed below.

    Hyaluronic acid has also been used in the synthesis of biological scaffolds for wound-healing applications. These scaffolds typically have proteins such as fibronectin attached to the hyaluronan to facilitate cell migration into the wound. This is particularly important for individuals with diabetes suffering from chronic wounds.

    INFLAMMATION

    In the early inflammatory phase of wound repair, wounded tissue is abundant in HA, probably a reflection of increased synthesis. HA acts as a promoter of early inflammation, which is crucial in the whole skin wound-healing process. It is interesting to note that HA has contradictory dual functions in the inflammatory process. It not only can promote the inflammation, but also can moderate the inflammatory response, which may contribute to the stabilization of granulation tissue matrix. Although inflammation is an integral part of granulation tissue formation, for normal tissue repair to proceed, inflammation needs to be moderated. The initial granulation tissue formed is highly inflammatory with a high rate of tissue turnover mediated by matrix degrading enzymes and reactive oxygen metabolites that are products of inflammatory cells. Stabilization of granulation tissue matrix can be achieved by moderating inflammation. HA functions as an important moderator in this moderation process, which contradicts its role in inflammatory stimulation. HA can protect against free-radical damage to cells. This may attribute to its free-radical scavenging property, a physicochemical characteristic shared by large polyionic polymers. HA has been shown to reduce damage to the granulation tissue. In addition to the free-radical scavenging role, HA may also function in the negative feedback loop of inflammatory activation through its specific biological interactions with the biological constituents of inflammation.

    GRANULATION

    Granulation tissue is the perfused, fibrous connective tissue that replaces a fibrin clot in healing wounds. It typically grows from the base of a wound and is able to fill wounds of almost any size it heals. HA is abundant in granulation tissue matrix. A variety of cell functions that are essential for tissue repair may attribute to this HA-rich network. These functions include facilitation of cell migration into the provisional wound matrix, cell proliferation and organization of the granulation tissue matrix. Initiation of inflammation is crucial for the formation of granulation tissue, therefore the pro-inflammatory role of HA also contributes to this stage of wound healing.

    CELL MIGRATION

    Cell migration is essential for the formation of granulation tissue. The early stage of granulation tissue is dominated by a HA-rich extracellular matrix, which is regarded as a conducive environment for migration of cells into this temporary wound matrix. Contributions of HA to cell migration may attribute to its physicochemical properties, as well as its direct interactions with cells. HA provides an open hydrated matrix that facilitates cell migration, whereas, directed migration and control of the cell locomotory mechanisms are mediated via the specific cell interaction between HA and cell surface HA receptors. The three principal cell surface receptors for HA are CD44, RHAMM, and ICAM-1. RHAMM is more related to cell migration. It forms links with several protein kinases associated with cell locomotion, for example, extracellular signal-regulated protein kinase (ERK), p125fak, and pp60c-src. During fetal development, the migration path through which neural crest cells migrate is rich in HA. HA is closely associated with the cell migration process in granulation tissue matrix, and studies show that cell movement can be inhibited, at least partially, by HA degradation or blocking HA receptor occupancy.

    By providing the dynamic force to the cell, HA synthesis has also been shown to associate with cell migration. Basically, HA is synthesized at the plasma membrane and released directly into the extracellular environment. This may contribute to the hydrated microenvironment at sites of synthesis, and is essential for cell migration by facilitating cell detachment.

    SKIN HEALING

    HA plays an important role in the normal epidermis. HA also has crucial functions in the reepithelization process due to several of its properties. It serves as an integral part of the extracellular matrix of basal keratinocytes, which are major constituents of the epidermis; its free-radical scavenging function and its role in keratinocyte proliferation and migration.

    In normal skin, HA is found in relative high concentrations in the basal layer of the epidermis where proliferating keratinocytes are found. CD44 is collocated with HA in the basal layer of epidermis where additionally it has been shown to be preferentially expressed on plasma membrane facing the HA-rich matrix pouches. Maintaining the extracellular space and providing an open, as well as hydrated, structure for the passage of nutrients are the main functions of HA in epidermis. A report found HA content increases at the presence of retinoic acid (vitamin A). The proposed effects of retinoic acid against skin photo-damage and aging may be correlated, at least in part, with an increase of skin HA content, giving rise to increase of tissue hydration. It has been suggested the free-radical scavenging property of HA contributes to protection against solar radiation, supporting the role of CD44 acting as a HA receptor in the epidermis. Epidermal HA also functions as a manipulator in the process of keratinocyte proliferation, which is essential in normal epidermal function, as well as during reepithelization in tissue repair. In the wound healing process, HA is expressed in the wound margin, in the connective tissue matrix, and collocating with CD44 expression in migrating keratinocytes.

    FETAL WOUND HEALING

    Lack of fibrous scarring is the primary feature of fetal wound healing. Even for longer periods, HA content in fetal wounds is still higher than that in adult wounds, which suggests that HA may, at least in part, reduce collagen deposition and therefore lead to reduced scarring. This suggestion is in agreement with research that showed in adult and late gestation fetal wound healing, removal of HA results in fibrotic scarring.

    MEDICAL USES OF HYALURONIC ACID

  • Hyaluronic acid has been used in attempts to treat osteoarthritis of the knee via injecting it into the joint. HA might be effective for stiffness and joint pain when injected into the joint by a health care provider. Despited being approved by the FDA for treatment of osteoarthritis by injection, results vary. It has not been proven, however, to generate significant benefit and has potentially severe adverse effects. Some people report a moderate improvement in joint stiffness and pain decrease with hyaluronic acid treatment, but this is not always the case. Whether hyaluronic acid might delay or lessen progressive joint damage with long-term use is unknown.

  • Dry, scaly skin such as that caused by atopic dermatitis may be treated with skin lotion containing sodium hyaluronate as its active ingredient. Sores in the mouth is effectively treated by hyaluronic acid when applied to the skin as a gel. Hyaluronic acid has been used for healing skin wounds and burns. Early research suggests that applying hyaluronic acid to the skin might be helpful for treating burns and skin wounds.

  • Hyaluronic acid has been used in various formulations to create artificial tears to treat dry eye. Early research shows that applying a specific hyaluronic acid eye drop (Hyalistil) might relieve dry eye. For cataracts, injecting hyaluronic acid into the eye is effective when used during cataract surgery by an eye surgeon. For eye trauma, some research suggests that hyaluronic acid might be injected into the eye to treat detached retina or other eye injuries.

  • COSMETIC USES

    Hyaluronic acid is a common ingredient in skin-care products. Hyaluronic acid is used as a dermal filler in cosmetic surgery. It is typically injected using either a classic sharp hypodermic needle or a cannula. Some aging skin research suggests that injecting a specific hyaluronic acid product into smile lines reduces the lines for up to one year. Complications include the severing of nerves and vessels, pain and bruising. In some cases hyaluronic acid fillers result in a granulomatous foreign body reaction.





    HYLURONIC ACID DOSAGE INFORMATION

    Hyaluronic acid is a substance that is naturally present in the human body. It is a naturally occurring polysaccharide (carbohydrate) and is prexent in large amounts in the spaces between skin cells, where it provides moisture, plumpness, firmness and suppleness to the skin. Baby's are born with a high level of hyaluronic acid, which keeps their skin plump and smooth. Unfortunately, the amount of hyaluronic acid in skin diminishes with age, most significantly after age 40. While you may not get back to your baby suppleness, it is possible to help restore the skin’s hyaluronic acid content and give grown-up skin a younger, fresher, more supple look. One way to do it is through hyaluronic acid fillers, which a dermatologist or plastic surgeon injects directly into sunken or wrinkled areas to plump them up. The other way to help plump up skin is to use a serum or moisturizer that contains hyaluronic acid. While it will not give you the dramatic, instantaneous results that a hyaluronic acid filler can, you will see benefits in the form of softer, smoother, more hydrated skin. Applied topically, it increases hydration, improves elasticity and also reverses free radical damage, so it may have some benefit in protecting from UV damage. Hyaluronic acid is one ingredient that works across the board. Every skin type, even oily, can benefit. Look for hyaluronic acid serums and apply one alone if you have oily skin or under moisturizer if you have dry skin.

    HOMEMADE HYALURONIC ACID SKIN CARE SERUM RECIPE

    A homemade hyaluronic acid skin care serum is relatively uncomplicated to make for use as a skin moisturizer by applying to the skin. This is not used for injection purposes, only for skin applications.

    Hyaluronic acid powder can be difficult to dissolve, so to save aggrevation with small batches, make a larger amount and keep it in the refrigerator until ready to use. The recipe works better when the solution is cold.

    STOCK 1-Percent SERUM RECIPE

    0.6 grams Pure Hyaluronic Acid Powder (approximately 1/4 teaspoon)
    60 ml Distilled Water
    A few drops of Optiphen (preservative)


    1. Weigh our Hyaluronic Acid Powder.
    2. Pour 60 ml of distilled water into a plastic bottle.
    3. Add the powdered Hyaluronic Acid to the distilled water, close the cap tightly.
    4. Shake the bottle vigorously. You will possible have globs and bits of undissolved powder even after shaking. This is normal.
    5. Put in the refrigerator. You can take it out every 5 minutes or so to give it another shake to help it dissolve as quickly as possible. It may take 20 minutes or so, but it will generally fully dissolve into a homogenous gel within one to two hours.

    Makes 60 ml 1-percent Hyaluronic Acid Serum. For measurement purposes, 60 ml equals 2 fluid ounces or 1/4 cup.

    You can use hydrosols, aloe vera juice, and other skin loving products instead of distilled water or you can make a plain stock serum and add the other products later.

    If adding Vitamin B-5 to the stock recipe, mix 0.6 grams vitamin powder into the distilled water first to dissolve then add the hyaluronic acid. Follow stock recipe instructions as usual. Use a dark colored bottle as light breaks down the ingredients. Discard after a month as it will lose its potency.


    HA is found in the highest concentrations in fluids in the eyes and joints. The hyaluronic acid that is used as medicine is extracted from rooster combs or made by bacteria in the laboratory. People take hyaluronic acid for various joint disorders, including osteoarthritis. It can be taken by mouth or injected into the affected joint by a healthcare professional. The FDA has approved the use of hyaluronic acid during certain eye surgeries including cataract removal, corneal transplantation, and repair of a detached retina and other eye injuries. It is injected into the eye during the procedure to help replace natural fluids. Hyaluronic acid is also used as a lip filler in plastic surgery. Some people apply hyaluronic acid to the skin for healing wounds, burns, skin ulcers, and as a moisturizer. There is also a lot of interest in using hyaluronic acid to prevent the effects of aging. In fact, hyaluronic acid has been promoted as a "fountain of youth." However, there is no evidence to support the claim that taking it by mouth or applying it to the skin can prevent changes associated with aging. Hyaluronic acid works by acting as a cushion and lubricant in the joints and other tissues. In addition, it might affect the way the body responds to injury.

    For treating osteoarthritis, health care providers inject hyaluronic acid into the knee joint (or other affected joint).

    As a dietary supplement, take 2 Vcaps of hyaluronic acid 1 to 2 times daily, preferably with meals or follow label instructions carefully.

    Hydraplenish Plus OptiMSM has superior bioavailability and a lower molecular weight than other sources of hyaluronic acid. Moisturizes and rejuvenates skin, lubricates and cushions joints. Hydraplenish Plus OptiMSM contains the patented BioCell Collagen II complex for healthy connective tissue and synovial fluid--plus OptiMSM to support healthy hair, skin, nails and joints. Hydraplenish (without OptiMSM) contains the patented BioCell Collagen II complex for healthy connective tissue and synovial fluid. Hydraplenish has superior bioavailability and a lower molecular weight than other sources of hyaluronic acid. Hyaluronic acid is a gelatin-like fluid that acts as a natural lubricant and shock absorbent within the body. It is an important part of healthy connective tissue, and is also abundant in the eyes, joints, heart valves and skin. Take 2 capsules daily. For intensive use: Take 4 capsules daily.





    HYLURONIC ACID SAFETY, CAUTIONS, & INTERACTIONS

    Hyaluronic acid is considered likely safe when taken by mouth, applied to the skin, or given by injection and appropriately. Rarely, hyaluronic acid may cause allergic reactions in some sensitive individuals. There is no information for hyaluronic acid interactions.

    SPECIAL PRECAUTIONS

    Hyaluronic acid is considered possibly sfe when given by injection during pregnancy. However, not enough is know about the safety of hyaluronic acid when taken orally or applied to the skin during pregnancy. Stay on the safe side and avoid use unless instructed by a health care provider.

    Hyaluronic acid is possibly unsafe when given by injection during breastfeeding. Researchers do not know if it affects breast milk and what effect that it might have on an infant. There is not enough reliable research or information about the safety of taking hyaluronic acid by mouth or applying it to the skin if you are breastfeeding. Stay on the safe side and avoid use unless instructed by a health care provider.





    HYALURONIC ACID (HA) SUPPLEMENT PRODUCTS

  • Hyaluronic Acid & Hydraplenish Supplement Products


  • QUALITY SUPPLIES & PRODUCTS


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    HYDRAPLENISH & HYALURONIC ACID (HA) SUPPLEMENT PRODUCTS

    Hyaluronic acid is a natural substance found in abundance in young skin, synovial fluid, and other tissues in humans and animals. It provides bone and joint support. Hyaluronic Acid is an important constituent of joint fluid, where it serves as a lubricant and plays a role in resisting compressive forces. It is a linear polysaccharide in the glycosaminoglycan (GAG) family and is referred to as the “cement” that bonds tissue components together. Columns of fibers made up of collagen and elastin support the surface layers of the skin from below. This network of fibers forms a sponge-like structure known as connective tissue. The spaces within this sponge are filled with water, protein complexes, and hyaluronic acid. These substances form a jelly-like complex that is necessary for the transportation of essential nutrients from the bloodstream to the living cells of the skin.

    HERBSPRO PRODUCTS

    HerbsPro: Hydraplenish Hyaluronic Acid, Natures Way, 30 VCaps (67186)
    HerbsPro: Hydraplenish Hyaluronic Acid With MSM, Natures Way, 30 VCaps (67188)
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    HerbsPro: Hydraplenish 88% Hyaluronic Acid Serum, Natures Way, 1 fl. oz. (82173)
    HerbsPro: Hyaluronic Acid, Powerful Antiarthritic and Antiwrinkle Supplement, Woodland Publishing, 32 Page Booklet (90320)
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    HerbsPro: Hyaluronic Joint Complex, Source Naturals, 30 Tabs (70095)
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    HerbsPro: Hyaluronic Acid From BioCell Collagen, Source Naturals, 50 mg, 30 Tabs (37979)
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    HerbsPro: Hyaluronic Acid From BioCell Collagen, Source Naturals, 50 mg, 60 Tabs (37980)
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    HerbsPro: Hyaluronic Acid Formula, California Natural, 50 mg, 90 Caps (44921)
    HerbsPro: Hyaluronic Acid From BioCell Collagen, Source Naturals, 50 mg, 120 Tabs (37981)
    HerbsPro: Hyaluronic Acid With MSM, Now Foods, 50 mg, 120 VCaps (68334)
    HerbsPro: Hyaluronic Acid, Source Naturals, 50 mg, 120 Caps (69808)
    HerbsPro: Hyaluronic Acid, Source Naturals, 50 mg, 120 Tabs (62829)
    HerbsPro: Hyaluronic Acid With Chondroitin Sulfate, Doctors Best, 50 mg, 180 Caps (86521)
    HerbsPro: Hyaluronic Acid, Source Naturals, 70 mg, 30 Softgels (31263)
    HerbsPro: Hyaluronic Acid, Source Naturals, 70 mg, 60 Softgels (31264)
    HerbsPro: Hyaluronic Acid, Source Naturals, 100 mg, 30 Tabs (70044)
    HerbsPro: Hyaluronic Acid, Now Foods, 100 mg, 60 VCaps (71683)
    HerbsPro: Hyaluronic Acid, Vita Plus, 100 mg, 60 Caps (73829)
    HerbsPro: Hyaluronic Acid, Source Naturals, 100 mg, 60 Tabs (70045)
    HerbsPro: Hyabest Hyaluronic Acid, Natural Factors, Ultra Pure, 100 mg, 60 VCaps (91364)
    HerbsPro: Hyaluronic Acid, Now Foods, 100 mg, 120 VCaps (94311)
    HerbsPro: Hyaluronic Acid, Solgar, 120 mg, 30 Tabs (100223)
    HerbsPro: Natural Hyaluronic Acid, Life Time Nutritional Specialties, 140 mg, 30 VCaps (89831)
    HerbsPro: Pure Hyaluronic Acid Liquid, Neocell Labs, Blueberry, 50 mg, 16 fl. oz. (78712)
    HerbsPro: Liquid Hyaluronic Acid, Now Foods, Berry Flavor, 100 mg, 16 fl. oz. (94312)
    Hyaluronic Acid is a lubricant present in every tissue of the body, with the highest concentrations occurring in connective tissues such as skin and cartilage. As a constituent of joint fluid, Hyaluronic Acid also serves as a lubricant and plays a role in resisting compressive forces. Our formula combines this essential component with Vitamin D and other nutrients that are essential for the formation of collagen found in cartilage and connective tissue to support optimal joint health.
    HerbsPro: Liquid Collagen With Hyaluronic Acid & D-3, Life Time Nutritional Specialites, Berry, 16 fl. oz. (106038)
    HerbsPro: Pycnogenol & Hyaluronic Acid Eye Creme, Derma-E, 0.5 oz. (49986)
    HerbsPro: Hyaluronic Facial Moisturizer, Life Extension, 1 oz. (92034)
    HerbsPro: Hyaluronic Oil-Free Facial Moisturizer, Life Extension, 1 oz. (92035)
    HerbsPro: Hyaluronic Acid 65% SeruGel, Devita Natural Skin Care, 1 oz. (76547)
    DeVita's oil-free SeruGel will quench your thirsty skin cells by helping to deliver maximum amounts of Hyaluronic Acid (65% solution) to the skin using our unique Organic Aloe Vera delivery system. Hyaluronic acid contributes to the skin''s elasticity and suppleness, and minimizes the look of lines and wrinkles by seeming to plump-up the skin. Helps to prevent premature signs of aging, soften facial lines and nourish collagen. Fast-absorbing, and ideal for all skin types.
    HerbsPro: Hyaluronic Acid Serum, Larenim, 1 oz. (105963)
    HerbsPro: Hyaluronic Acid Serum, Now Foods, 1 oz. (68313)
    HerbsPro: Hyaluronic Acid Serum, Reviva, 1 fl. oz. (62774)
    HerbsPro: Skin Eternal Hyaluronic Serum, Source Naturals, 1 fl. oz. (62845)
    HerbsPro: Skin Eternal Hyaluronic Serum, Source Naturals, 1.7 fl. oz. (62846)
    HerbsPro: Life & Firm Cream, Age Defying Hyaluronic DMAE, Andalou Naturals, 1.7 oz. (108499)
    HerbsPro: Hyaluronic Hydration Mist, Larenim, 1.8 oz. (106136)
    HerbsPro: Hyaluronic Acid Firming Serum, Derma-E, 2 oz. (49463)
    HerbsPro: Hyaluronic Acid Day Creme Rehydrating Formula, Derma-E, 2 oz. (46461)
    HerbsPro: Hyaluronic Acid Night Creme Intensive Rehydrating Formula, Derma-E, 2 oz. (49462)
    HerbsPro: Hyaluronic Acid Creme, Now Foods, 2 oz. Tube (68314)
    HerbsPro: Hyaluronic Acid Moisturizer, Now Foods, 2 oz. Tube (68312)
    HerbsPro: Hyaluronic Cream, Life-Flo, 3 oz. (67338)
    HerbsPro: Hyaluronic Acid Moisturizing Cream, Home Health, 4 oz. (70776)
    HerbsPro: Hyaluronic Acid Rejuvenating, Home Health, 8 oz. (73538)
    HerbsPro: Hyaluronic Acid Ampules, Topical Application, Reviva, 10 Vials (35485)


    AMAZON PRODUCTS

    Amazon: Hyaluronic Acid Products
    Amazon: Pure Hyaluronic Acid Powder Supplement Products
    Amazon: Hyaluronic Acid Supplement Products
    Amazon: Hyaluronic Acid Beauty & Personal Care Products

  • Nutrition Basics: Hyaluronic Acid (HA) Supplement Information






  • MoonDragon's Womens Health Index

    | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |






    Health & Wellness Index





    AROMATHERAPY: ESSENTIAL OILS DESCRIPTIONS & USES


    Allspice Leaf Oil
    Angelica Oil
    Anise Oil
    Baobab Oil
    Basil Oil
    Bay Laurel Oil
    Bay Oil
    Benzoin Oil
    Bergamot Oil
    Black Pepper Oil
    Chamomile (German) Oil
    Cajuput Oil
    Calamus Oil
    Camphor (White) Oil
    Caraway Oil
    Cardamom Oil
    Carrot Seed Oil
    Catnip Oil
    Cedarwood Oil
    Chamomile Oil
    Cinnamon Oil
    Citronella Oil
    Clary-Sage Oil
    Clove Oil
    Coriander Oil
    Cypress Oil
    Dill Oil
    Eucalyptus Oil
    Fennel Oil
    Fir Needle Oil
    Frankincense Oil
    Geranium Oil
    German Chamomile Oil
    Ginger Oil
    Grapefruit Oil
    Helichrysum Oil
    Hyssop Oil
    Iris-Root Oil
    Jasmine Oil
    Juniper Oil
    Labdanum Oil
    Lavender Oil
    Lemon-Balm Oil
    Lemongrass Oil
    Lemon Oil
    Lime Oil
    Longleaf-Pine Oil
    Mandarin Oil
    Marjoram Oil
    Mimosa Oil
    Myrrh Oil
    Myrtle Oil
    Neroli Oil
    Niaouli Oil
    Nutmeg Oil
    Orange Oil
    Oregano Oil
    Palmarosa Oil
    Patchouli Oil
    Peppermint Oil
    Peru-Balsam Oil
    Petitgrain Oil
    Pine-Long Leaf Oil
    Pine-Needle Oil
    Pine-Swiss Oil
    Rosemary Oil
    Rose Oil
    Rosewood Oil
    Sage Oil
    Sandalwood Oil
    Savory Oil
    Spearmint Oil
    Spikenard Oil
    Swiss-Pine Oil
    Tangerine Oil
    Tea-Tree Oil
    Thyme Oil
    Vanilla Oil
    Verbena Oil
    Vetiver Oil
    Violet Oil
    White-Camphor Oil
    Yarrow Oil
    Ylang-Ylang Oil
    Aromatherapy
    Healing Baths For Colds
    Aromatherapy
    Herbal Cleansers
    Using Essential Oils


    AROMATHERAPY: HERBAL & CARRIER OILS DESCRIPTIONS & USES


    Almond, Sweet Oil
    Apricot Kernel Oil
    Argan Oil
    Arnica Oil
    Avocado Oil
    Baobab Oil
    Black Cumin Oil
    Black Currant Oil
    Black Seed Oil
    Borage Seed Oil
    Calendula Oil
    Camelina Oil
    Castor Oil
    Coconut Oil
    Comfrey Oil
    Evening Primrose Oil
    Flaxseed Oil
    Grapeseed Oil
    Hazelnut Oil
    Hemp Seed Oil
    Jojoba Oil
    Kukui Nut Oil
    Macadamia Nut Oil
    Meadowfoam Seed Oil
    Mullein Oil
    Neem Oil
    Olive Oil
    Palm Oil
    Plantain Oil
    Plum Kernel Oil
    Poke Root Oil
    Pomegranate Seed Oil
    Pumpkin Seed Oil
    Rosehip Seed Oil
    Safflower Oil
    Sea Buckthorn Oil
    Sesame Seed Oil
    Shea Nut Oil
    Soybean Oil
    St. Johns Wort Oil
    Sunflower Oil
    Tamanu Oil
    Vitamin E Oil
    Wheat Germ Oil





    HELPFUL RELATED MOONDRAGON NUTRITION BASICS LINKS

  • MoonDragon's Nutrition Basics Index
  • MoonDragon's Nutrition Basics: Amino Acids Index
  • MoonDragon's Nutrition Basics: Antioxidants Index
  • MoonDragon's Nutrition Basics: Enzymes Information
  • MoonDragon's Nutrition Basics: Herbs Index
  • MoonDragon's Nutrition Basics: Homeopathics Index
  • MoonDragon's Nutrition Basics: Hydrosols Index
  • MoonDragon's Nutrition Basics: Minerals Index
  • MoonDragon's Nutrition Basics: Mineral Introduction
  • MoonDragon's Nutrition Basics: Dietary & Cosmetic Supplements Index
  • MoonDragon's Nutrition Basics: Dietary Supplements Introduction
  • MoonDragon's Nutrition Basics: Specialty Supplements
  • MoonDragon's Nutrition Basics: Vitamins Index
  • MoonDragon's Nutrition Basics: Vitamins Introduction


  • NUTRITION BASICS ARTICLES

  • MoonDragon's Nutrition Basics: 4 Basic Nutrients
  • MoonDragon's Nutrition Basics: Avoid Foods That Contain Additives & Artificial Ingredients
  • MoonDragon's Nutrition Basics: Is Aspartame A Safe Sugar Substitute?
  • MoonDragon's Nutrition Basics: Guidelines For Selecting & Preparing Foods
  • MoonDragon's Nutrition Basics: Foods That Destroy
  • MoonDragon's Nutrition Basics: Foods That Heal
  • MoonDragon's Nutrition Basics: The Micronutrients: Vitamins & Minerals
  • MoonDragon's Nutrition Basics: Avoid Overcooking Your Foods
  • MoonDragon's Nutrition Basics: Phytochemicals
  • MoonDragon's Nutrition Basics: Increase Your Consumption of Raw Produce
  • MoonDragon's Nutrition Basics: Limit Your Use of Salt
  • MoonDragon's Nutrition Basics: Use Proper Cooking Utensils
  • MoonDragon's Nutrition Basics: Choosing The Best Water & Types of Water





  • RELATED MOONDRAGON HEALTH LINKS & INFORMATION

  • MoonDragon's Nutrition Information Index
  • MoonDragon's Nutritional Therapy Index
  • MoonDragon's Nutritional Analysis Index
  • MoonDragon's Nutritional Diet Index
  • MoonDragon's Nutritional Recipe Index
  • MoonDragon's Nutrition Therapy: Preparing Produce for Juicing
  • MoonDragon's Nutrition Information: Food Additives Index
  • MoonDragon's Nutrition Information: Food Safety Links
  • MoonDragon's Aromatherapy Index
  • MoonDragon's Aromatherapy Articles
  • MoonDragon's Aromatherapy For Back Pain
  • MoonDragon's Aromatherapy For Labor & Birth
  • MoonDragon's Aromatherapy Blending Chart
  • MoonDragon's Aromatherapy Essential Oil Details
  • MoonDragon's Aromatherapy Links
  • MoonDragon's Aromatherapy For Miscarriage
  • MoonDragon's Aromatherapy For Post Partum
  • MoonDragon's Aromatherapy For Childbearing
  • MoonDragon's Aromatherapy For Problems in Pregnancy & Birthing
  • MoonDragon's Aromatherapy Chart of Essential Oils #1
  • MoonDragon's Aromatherapy Chart of Essential Oils #2
  • MoonDragon's Aromatherapy Tips
  • MoonDragon's Aromatherapy Uses
  • MoonDragon's Alternative Health Index
  • MoonDragon's Alternative Health Information Overview
  • MoonDragon's Alternative Health Therapy Index
  • MoonDragon's Alternative Health: Touch & Movement Therapies Index
  • MoonDragon's Alternative Health Therapy: Touch & Movement: Aromatherapy
  • MoonDragon's Alternative Therapy: Touch & Movement - Massage Therapy
  • MoonDragon's Alternative Health: Therapeutic Massage
  • MoonDragon's Holistic Health Links Page 1
  • MoonDragon's Holistic Health Links Page 2
  • MoonDragon's Health & Wellness: Nutrition Basics Index
  • MoonDragon's Health & Wellness: Therapy Index
  • MoonDragon's Health & Wellness: Massage Therapy
  • MoonDragon's Health & Wellness: Hydrotherapy
  • MoonDragon's Health & Wellness: Pain Control Therapy
  • MoonDragon's Health & Wellness: Relaxation Therapy
  • MoonDragon's Health & Wellness: Steam Inhalation Therapy
  • MoonDragon's Health & Wellness: Therapy - Herbal Oils Index







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    MOONDRAGON'S REALM - WEBSITE DIRECTORY


    A website map to help you find what you are looking for on MoonDragon.org's Website. Available pages have been listed under appropriate directory headings.




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