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MoonDragon's Health & Wellness
Nutrition Basics

Supplements
CHELATING AGENTS

(Removing Heavy Metals & Chemicals)


For Informational Use Only
For more detailed information contact your health care provider
about options that may be available for your specific situation.





  • Chelaton Therapy & Oral Chelation Agents
  • Chelation of Chemicals & Heavy Metals
  • Chelation Methods & Products Used
  • Chelation Related Supplement Products




  • CHELATION THERAPY & ORAL CHELATION AGENTS INFORMATION

    AN OVERVIEW

    Chelation therapy is a safe and non surgical method of treatment for the removal of excess body toxins. Chelation is the process by which the chelating agent bonds with the unwanted toxins. Chealtors draw out excess toxins including plaque, thereby restoring circulation to blocked veins and arteries, and the removal of toxic metals such as cadmium, lead or mercury. Chelation is the process by which the chelating agent bonds with the unwanted toxins. Toxins which enter the body through food, water and other means can be eliminated via the kidneys, helping to restore circulation to the body's tissues.

    As certain toxic minerals accumulate in the body they can interact, interfere, or inhibit the actions of other important minerals. For example, lead has been shown to interfere with the actions of calcium, iron, and potassium. The Chelation process removes these toxic minerals allowing the essential minerals and nutrients to do their job.

    Chelation Therapy is used in the treatment of atherosclerosis, various circulatory disorders, and gangrene - which is the result of poor circulation. Atherosclerosis is the formation of cholesterol and fat deposits on the walls of arteries in the form of hard plaque. Calcium has been found to be the "glue" which binds the atherosclerotic plaque together. Chelating agents bind with this calcium and carry it out of the body, thus breaking up the plaque deposits, unclogging the arteries, improving the blood flow.

    BEHAVIORAL, STRUCTURAL, FUNCTIONAL ABNORMALITIES
    ASSOCIATED WITH VARIOUS HEAVY METAL TOXINS IN THE BODY
    PSYCHIATRIC DISTURBANCES

    Social Deficits
    Social Withdrawal

    Mercury

    Repetitive
    Perseverative
    Stereotyped Behaviors
    OCD-Typical Behaviors

    Mercury

    Depression
    Mood Swings
    Flat Affect
    Impaired Facial Recognition

    Arsenic
    Copper
    Lead
    Mercury

    Schizoid Tendencies
    Hallucinations
    Delirium

    Mercury

    Irritability
    Aggressive Behaviors
    Temper Tantrums

    Lead
    Mercury

    Suicidal Behaviors

    Copper
    Mercury

    Sleep Difficulties
    Sleep Disturbances

    Lead
    Mercury
    Thallium

    Chronic Fatigue (CFS)
    Weakness
    Malaise

    Aluminum
    Arsenic
    Cadmium
    Copper
    Lead
    Mercury
    Thallium

    Anorexia
    Eating Disorder Symptoms
    Loss of Appetite
    Loss of Weight

    Arsenic
    Lead
    Mercury

    Anxiety
    Nervous Tendencies

    Thallium

    Attentional Problems (ADHD)
    Lacks Eye Contact
    Impaired Visual Fixation

    Lead
    Mercury
    SPEECH & LANGUAGE DEFICITS

    Speech Disorders

    Aluminum
    Mercury

    Loss of Speech
    Developmental Problems With Language

    Mercury

    Speech Comprehension Deficits

    Mercury

    Dysarthria
    Articulation Problems
    Slurred Speech
    Unintelligible Speech

    Mercury
    COGNITIVE IMPAIRMENTS

    Mental Retardation
    Borderline Intelligence

    Arsenic
    Lead
    Mercury

    Uneven Performance on IQ Scores
    Low IQ Scores

    Copper
    Lead

    Poor Concentration
    Attention Deficits (ADHD)
    Response Inhibition

    Aluminum
    Lead

    Poor Memory
    (Short Term, Verbal, & Auditory)

    Aluminum
    Lead

    Difficulties Understanding Abstract Ideas
    Difficulty Carrying Out Complex Commands

    X Metals

    Dementia
    Pre-senile & Senile Dementia

    Aluminum

    Stupor

    Aluminum
    Arsenic

    Impaired Reaction Time
    Lower Performance on Timed Tests

    Lead
    SENSORY ABNORMALITIES

    Abnormal Sensations
    In the Mouth & Extremities

    Arsenic

    Hearing Loss
    Difficulty Hearing

    Arsenic
    Lead
    Mercury

    Abnormal Touch Sensations
    Diminished Touch Sensations
    Aversion To Touch

    Arsenic

    Blurred Vision
    Sensitivity To Light

    Arsenic
    Mercury
    MOTOR DISORDERS

    Choreiform Movements
    Myoclonal Jerks
    Unusual Postures

    Copper
    Mercury

    Difficulty Walking
    Difficulty Swallowing
    Difficulty Talking

    Copper
    Mercury

    Flapping
    Circling
    Rocking
    Toe Walking

    Mercury

    Problems With Intentional Movements or Imitation

    Mercury

    Abnormal Gait
    Abnormal Posture
    Incoordination
    Loss of Balance
    Problems Sitting
    Problems Lying
    Problems Crawling
    Problems Walking

    Mercury

    Decreased Locomotor Activity

    Aluminum
    Arsenic

    Convulsion
    Seizure

    Aluminum
    Arsenic
    Copper
    Lead
    Mercury
    Thallium
    PHYSIOLOGICAL IMPAIRMENT, BRAIN & CENTRAL NERVOUS SYSTEM

    Neurofibrillary Tangles

    Aluminum

    Neuritis
    Retrobulbar Neuritis
    Neuropathy

    Aluminum
    Arsenic
    Lead
    Thallium

    Encephalopathy

    Aluminum
    Arsenic
    Lead
    Thallium

    Cerebrovascular Disease

    X Metals

    Alterations in Nerve Conduction Velocity

    Lead

    Alterations in the Spinal Cord

    Thallium

    Accumulates in CNS Structures

    Aluminum
    Mercury

    Abnormal EEGs

    Arsenic
    Lead

    Autonomic Disturbances

    Copper
    Lead
    Mercury
    Thallium
    PERIPHERAL NERVOUS SYSTEM

    Peripheral Neuropathy

    Arsenic
    Mercury

    Alterations in the Peripheral Nerves

    Arsenic

    Loss of Feeling
    Numbness in the Extremities
    Paresthesia

    Arsenic
    Mercury
    Thallium
    GASTROINTESTINAL TRACT

    Nausea
    Vomiting
    Diarrhea
    Loss of Appetite

    Arsenic
    Mercury

    Abdominal Pain
    Stomach Cramps
    Burning of Throat
    Burning of the Mouth

    Arsenic
    Copper
    Lead
    Mercury
    Thallium

    Cancers
    (Colon, Pancreatic, Stomach, or Rectal)

    Arsenic

    Esophagitis
    Gastroenteritis
    Colitis

    Arsenic
    Mercury
    Thallium
    RENAL & HEPATIC IMPAIRMENT

    Hepatotoxicity
    Liver Dysfunction
    Damage

    Arsenic
    Copper
    Thallium

    Cirrhosis of the Liver
    Hepatitis

    Copper

    Kidney Disease
    Kidney Failure

    Arsenic
    Lead
    Mercury

    Renal Toxicity
    Tubular Proteinosis

    Arsenic
    Copper
    Lead

    Kidney Damage
    Histological Alterations

    Arsenic
    Lead
    CARDIOVASCULAR SYSTEM

    Blood Vessel Damage

    Arsenic

    Anemia
    Decreased Red Blood Cell Count

    Arsenic
    Copper

    Hypertension
    Increased Heart Rate (Tachycardia)

    Arsenic
    Copper
    Lead
    Thallium

    Electrocardiac Disorders
    Peripheral Vascular Disease
    Cardiovascular Disease
    Vascular Collapse

    Arsenic
    Lead
    RESPIRATORY SYSTEM

    Pulmonary Fibrosis

    Aluminum
    Arsenic

    Pulmonary Edema

    X Metals

    Pneumonia
    Laryngitis
    Pharyngitis
    Bronchitis

    Aluminum
    Arsenic
    Mercury

    Restrictive Airway Disorders
    Asthmatic Conditions
    Pneumoconiosis

    Arsenic
    Aluminum

    Nasal Ulcers
    Perforation of the Nasal Septum

    X Metals
    IMMUNE SYSTEM

    Increased Incidences of Asthma
    Autoimmune-like Symptoms
    & Allergies

    X Metals

    Inhibition of Lymphocytes, T-Cells, Monocytes

    X Metals

    Immunosuppression

    Lead

    Decreased White Blood Cell Count

    Arsenic
    Thallium
    REPRODUCTIVE SYSTEM

    Genital Abnormalities

    Aluminum
    Thallium

    Disturbances In Menstrual Cycle
    Menstrual Pains

    Copper
    Mercury

    Birth Defects
    Premature Births
    Spontaneous Abortion

    Arsenic
    Lead
    Mercury

    Reproductive Dysfunction

    Arsenic
    Aluminum
    OTHER PHYSICAL DISTURBANCES

    Hypotonia or Hypertonia
    Decreased Muscular Strength

    X metal

    Rashes
    Contact Dermatitis
    Eczema
    Itchy, Irritating Skin

    Aluminum
    Arsenic
    Copper
    Mercury

    Muscle Pain
    Headache
    Acrodynia
    Colic

    Arsenic
    Copper
    Lead
    Thallium

    Alopecia (Hair Loss)

    Thallium


    ORAL CHELATION & INTRAVENOUS CHELATION

  • Intravenous Chelation Therapy: This may be done with intravenous solutions that must be administered by or under the supervision of a health care practitioner. It is used in extreme cases to remove hardened calcified plaque from the artery walls, thus improving circulation. This therapy is also used to remove heavy metals. Serious cases require multiple injections of the chelating agent.

  • Oral Chelation Therapy: This therapy is available in over the counter supplements and formulas and may be taken orally at home. Oral chelating agents offer a safe alternative for persons who are at risk of circulatory disorders or of problems caused by the accumulation of toxic metals. Conditions that may be improved by Chelation therapy include multiple sclerosis, Parkinson's Disease, Alzheimer's Disease, and arthritis. Many severely disabled and high risk individuals have reported dramatic improvement in arterial circulation after Chelation treatment.


  • ORAL CHELATION AGENTS

    The following agents may be used individually, in combination, or as formulated supplements to help prevent illnesses and in many cases alleviate the symptoms of existing conditions.
    • Alfalfa & Fiber: Helps detoxify the liver and raises the body PH levels. Chelates toxins from the body.
    • Rutin & Apple Pectin: Bind and Removes unwanted toxins through the intestinal tract.
    • Selenium: A powerful free radical scavenger.
    • Calcium & Magnesium Chelate With Potassium: Replaces calcium lost by Chelation.
    • Garlic
    • Coenzyme Q-10: Improves circulation and lowers blood pressure.
    • Sea Kelp, and Zinc Chelate.
    • L-Cysteine & L-Methionine: Two of the most important natural dietary chelators. Cysteine is effective for Nickel Chelation.
    • L-Lysine plus Glutathione: Detoxifies harmful toxins and metals and free radical scavenger (Caution - do not Lysine take longer than six months).
    • EDTA (ethylenediaminetetraacetic acid): This is the most common intravenous chelating agent and is used orally - A 1989 study, published in the Journal of Advancement in Medicine, used EDTA to treat 3,000 people with coronary artery disease and other vascular problems. nearly 90-percent experienced a significant improvement. EDTA attracts lead, strontium, calcium, and many other metals. EDTA therapy, oral and intravenous, should be accompanies with oral supplementation of Zinc, Chromium, Vitamin B-Complex and a general Multivitamin and Multimineral Complex.





    CHELATION OF CHEMICALS & HEAVY METALS

    In order to chelate chemicals and heavy metals you will need to decide upon which chelation method is best suited to your needs. Professional medical supervision is strictly advised. Medical practitioners do not endorse the taking of heavy metal chelators without such supervision, or for the purposes of clearing arterial plaque.

    The word chelate comes from the Greek word "claw" and chelation therapy is the process where heavy metal ions (molecules) are encircled and bound to the chelating agent. The agent then mobilizes the heavy metal ions, transporting them through the bodies usual detoxification pathways (liver, kidneys, gut) to be removed by excretion via the urine and stool.

    You can establish whether you have chemical and heavy metals toxicity by taking a hair, blood or urine test to check your heavy metals levels. Because heavy metals may not always show up on a test results it is important to first understand why this is. Chemicals and Heavy Metals typically become sequestered in the bodies lipid (fat) cells. Particularly those cells of the brain, nervous system, liver, kidneys, gall bladder, gut and soft tissue and are not always always freely available to be picked up and tested for in the hair, blood or urine. To get a truer understanding of your bodies full body burden of heavy metals this following test will more likely guarantee that you dont get negative results despite being toxic with heavy metals.

    If you go on a low carbohydrate diet for 8 weeks you will burn off some of the bodies fat cells, this then will release stored heavy metals into the hair, blood and urine where they can then be picked up and tested.

    CHELATION CONSIDERATIONS

    A) Type of Chemicals & Heavy Metals: Whether you need to chelate for example, lead or mercury, will determine which method or product is better suited. A list of chelators below have been included and some are also well adapted to binding with chemicals like hormone disrupting volatile organic compounds (V.O.C.s) and Pesticides. Pesticides include, herbicides, insecticides and fungicides.

    B) Location: The efficiency of heavy metal chelators to achieve intracellular (of the cell) and extracellular (outside the cell) cleansing is important. To chelate chemical and heavy metals you are concerned with removing the toxins from two locations.
    • Intracellular: Cell wall, where heavy metals become attached to receptor sites "knocking" off the beneficial healthy metals (in the right amount) like iron, zinc, magnesium, copper and manganese. Inside the cell, where heavy metals damage the mitochondria (cellular energy production) and D.N.A.

    • Extracellular: In the fluid (outside the cell wall) that contains amongst other components: proteins, metabolites and ions.
    C) Speed / Dosage: When you chelate you are also concerned with the pace with which this process is carried out. This is because chelating heavy metals at a too higher rate in comparisons to your liver and kidneys ability to remove toxins is detrimental to your health and can lead to kidney damage or in extreme incorrect dosing, fatality. People have either permanently damaged their kidneys and had terrible detox symptoms. (more likely if intravenous (I.V.) methods have been employed at the wrong dosage. I.V. challenge tests that administer as much as 3000 mg of the chelator over 6 hours, so they can then measure how much heavy metals have been excreted in the urine would be considered risky and far too high.

    WARNING: Heavy metal chelation administered by I.V. that is undertaken in a very short time frame - minutes - can lead to heart failure and fatality due to decreases in blood calcium levels.

    Caution is advised if you are very toxic, weak, have sensitivities to medications and vitamins. If you do need to chelate, hold off and take supplements that will support the liver and kidneys first. Taking lower levels of the chelator and to chelate over a longer time frame is recommended rather than aggressive high dosing over short periods of time.

    D) Half Life: The time that it takes for the metal chelator to break down and be eliminated from the body. If the product has a longer half life - subject to the chelators clathrating, claw-like ability to remove more heavy metals per time period - there is a greater ability for heavy metals that are now mobilized from the stores, to be removed before they are re-released and re-absorbed (re-toxification) back into the blood or tissue.

    E) Blood Brain Barrier: Consideration needs to be given as to whether the chelator crosses the blood brain barrier in order to pull toxic metals. The brain is made up of approximately 60-percent lipid (fat), other major organs as well as those of the hormonal system and nervous system are also rich in fats. Heavy metals lipid soluble characteristics allow them to be stored in those parts of the body.

    F) Amalgam Fillings: Do not use synthetic chelators or cilantro (see below) with amalgam fillings in place. Replace mercury amalgams with porcelain fillings before you chelate.

    HEAVY METAL DETOX SYMPTOMS

    Heavy metal detox symptoms can include but are not limited to:
    • Extreme Lethargy.
    • Headaches & Dizzyness.
    • Tissue, Muscle & Joint Aches.
    • Skin Irritation.
    • Bleeding Gums.
    • Loss of Appetite.
    • Stomach Upsets.
    • Nausea & Vomiting.
    In such circumstances it is important to cease chelating heavy metals. Increase the amount of water, chlorella, magnesium and vitamin C and undertake coffee enemasand butyrate enemas to relieve the liver. (Do NOT do enemas until you have taken butyrate for 2 weeks -- Do NOT risk blocking your biliary tree / bile ducts with sludge). Allow a suitable time for the body to recover one week or more. It is not a race.





    METHODS & PRODUCTS USED TO CHELATE CHEMICAL & HEAVY METALS

    NATURAL CHELATION METHODS

    HIGH FATS, LOW CARB (HFLC), HIGH PROTEIN DIET: This is a safe and natural way to chelate chemical and heavy metals. The results take a longer time to achieve. An example may be that you may still show tiny amounts of the heavy metal lead using the best machine computer diagnosis after two years. The aim is to burn fat cells and dump toxins whilst eating a low carb, high protein diet and to take extra fats (lipids) to help improve the cell wall (membrane) integrity and functioning. Repairing the cell membrane (wall) removes chemicals and heavy metals that get attached to the cell walls receptor sites. This enables better oxygen absorption and nutrition and waste disposal at the cellular level. i.e. allow the nutrients to get into the cells and allow waste out.

    ORGANIC CHLORELLA: Green single celled freshwater micro-algae composed of proteins, that binds with chemical and metal toxins and transports them out of the body. Increases the body's Glutathione output and repairs detoxification pathways.

    CILANTRO: This is a herb capable of mobilizing mercury, cadmium, lead and aluminum in both bones and the central nervous system. Can remobilize more metal toxins than it can carry risking flooding of toxins into the surrounding tissue as metal ions break free from the cilantro.

    WHEATGRASS: Primarily composed of Chlorophyll, wheatgrass is rich in nutrients, vitamins and amino acids which bind to chemicals and heavy metals and help to chelate them out of the body.

    ZEOLITES: Minerals suspended in water work by the process of clathration forming an attachment to toxic metals and chemicals with stable bonds. This prevents additional reactions with tissues or organs as the heavy metals are eliminated from the body. Research shows clinoptilolite zeolite selectively binds to toxins including mercury, lead, cadmium, arsenic, radioactive particles, pesticides and volatile organic compounds. The zeolite recommended has the smallest particle size of any of the zeolites seen and therefore the highest detoxing potential. It has also been granted GRAS status by the FDA.

    ALPHA LIPOIC ACID: This sulphur containing amino acid binds with heavy metals such as copper, iron, mercury and cadmium. Being both water and lipid (fat) soluble it has good bioavailability in the body. This can be taken with synthetic or natural chelating agents.

    SYNTHETIC CHELATION METHODS

    If you are going to chelate using synthetic chelators first consult with a health care practitioner, especially if taking prescription medicines. The following can be taken either as a suppository, orally or used in an I.V. to be administered over a short time period.

    DMSA (DIMERCAPTOSUCCINIC ACID): DMSA is a sulfur-containing organic amino acid compound. In America it is approved by the Food & Drug Administration (F.D.A.) for the treatment of lead and mercury toxicity both in children and adults. DMSA is a compound that has the ability to bind and remove heavy metals. It can be administered orally and as a suppository.

    In a healthy body, there are natural sulfur-containing compounds which perform remove heavy metals. They include N-acetyl-Cysteine (NAC), R-Lipoic Acid, A-Lipoic Acid, S-Adenysl Methionine (SAM-e), and Reduced Glutathione (rGSH). Along with DMPS these two chelators appear to deplete Cysteine which is an important amino acid precursor for the cells production of the bodies own natural anti oxidant, Glutathione (typically already at low levels in toxic individuals).

    Dimercaptosuccinic acid (DMSA), is the organosulfur compound with the formula HO2CCH(SH)CH(SH)CO2H. This colorless solid contains two carboxylic acid and two thiol groups, the latter being responsible for its mildly unpleasant odour. It occurs in two diastereomers, meso and the chiral dl forms. The meso isomer is used as a chelating agent. The acid is most often used as a treatment for heavy metal toxicity, and is a water soluble and non-toxic substance.

    DMSA was first synthesized by V. Nirenburg in the Urals Polytechnic Institute, commissioned by one of the electrical enterprises of Sverdlovsk, which consumed many tons of mercury and was looking for a medicine to prevent poisoning of personnel. In 1957, it was found by Chinese scientists that DMSA can effectively treat antimony poisoning due to overdose of tartar emetic. Pronounced protective effect in animal poisoning with arsenic and mercury was first shown by I. Okonishnikova in 1962. In 1984 the now-defunct Bock Pharmaceutical Company requested the FDA grant approval for Orphan drug status under the trade name Chemet and the FDA approved of this in 1991 providing exclusivity until 1998 which was conveyed to the successor Sanofi in 1996.

    DMSA may be prepared by reacting acetylenedicarboxylic acid with sodium thiosulfate or thioacetic acid followed by hydrolysis. The dimethyl ester is also known. Meso 2,3-dimercaptosuccinic acid binds to "soft" heavy metals such as Hg2+ and Pb2+, mobilizing these ions for excretion. It binds to metal cations through the thiol groups, which ionize upon complexation.

    Dimercaptosuccinic acid (Chemet) is indicated for the treatment of lead poisoning in children with blood level measured above 45 g/dL. The use of DMSA is not approved for prophylactic/prevention of lead poisoning in anticipation of exposure in known lead contaminated environments. Its elimination half-life is 2.5 to 3.5 hours. DMSA can cross the blood-brain barrier of mice, but not that of humans, limiting its use to extracting heavy metals from parts of the body other than the central nervous system.

    Another application for DMSA is for provocation of tissue heavy metals in anticipation of a urine test. This is sometimes called a "challenge" or "provoked" heavy metals test. DMSA is used to help mobilize heavy metals stored in body tissues (and therefore not typically present in the circulation) and increase the excretion of heavy metals in the urine. In a study by Howard Frumkin et al., this sort of test was shown to not reliably provide an indication of past chronic mercury exposure, something it was often used for. A 2004 study by GP Archbold, et al. called the results of a DMSA challenge test "misleading" for the purposes of diagnosing mercury toxicity. Moreover, DMSA share the limitation of extracellular distribution, which makes it unable to cross the cell membrane and chelate heavy metals from intracellular sites.

    The relative activities of a series of novel monoalkyl esters of meso-2,3-dimercaptosuccinic acid (MiADMSA) have been examined as agents for the mobilization of cadmium, lead and arsenic owing to the ability of these monoesters to cross cell membranes. The monoesters were found to be more effective than the parent compound DMSA. The complexes (monoesters of DMSA) seem to penetrate cells (not possible in the case of DMSA), which helps in targeting intracellular sites in the body and aids in the removal of toxic metal ions in the cytosol and organelles inside the cell.

    DMPS (DIMERCAPTOPROPANE SULFONATE): DMPS is an amino acid. In America this is not approved by the Food & Drug Administration (FDA). However in Germany due to it's safety record it is sold over the counter. It is regarded as a more potent agent in the removal of mercury. Problems arise when the dosage is incorrectly administered and too high. If heavy metals are pulled at too fast a rate they can damage tissue. Your kidneys and liver can only chelate (or process) so much toxin removal at any given time. Any "flood" of toxins will result in the metals being re-dumped between the liver and the bowel and not completely eliminated.

    2,3-Dimercapto-1-propanesulfonic acid (abbreviated DMPS) and its sodium salt (known as Unithiol) are chelating agents that form complexes with various heavy metals. They are related to dimercaprol, which is another chelating agent. The synthesis of DMPS was first reported in 1956 by V. E. Petrunkin. The effects of DMPS on heavy metal poisoning, including with polonium-210, were investigated in the following years. DMPS was found to have some protective effect, prolonging the survival time. A study was undertaken of DMPS use by workers involved in the production of a calomel skin bleaching lotion and in direct contact with mercurous chloride and that already showed elevated urine mercury levels. The sodium salt of DMPS was found to be effective in lowering the body burden of mercury and in decreasing the urinary mercury concentration to normal levels. DMPS administrated to a mercury poisoned animal model failed to remove the mercury from tissues and reduce the inorganic mercury burden in the brain. A 2008 study reported a case of Stevens-Johnson syndrome (SJS), a potentially serious disease, in a child undergoing chelation therapy with DMPS; the SJS resolved gradually after the chelation therapy was stopped.

    EDTA (ETHYLENE DIAMINE TETRAACETIC ACID): EDTA is an amino acid. In America this is a Food & Drug Administration (FDA) unapproved drug -- due it seems mainly due to marketing claims. It is more effective at removing heavier metals like lead and cadmium than removing mercury where it is not as effective in breaking the bonds formed between proteins and mercury. It will chelate in order of the heaviest metal (in the atomic table) to the lightest. It can be administered by I.V., orally and as a suppository. In suppository form it is time released and at a gentler, lower dosage (up to 2000mg) than those administered by I.V.s. Generally regarded as the safer of the synthetic chelators, in the past controversy has been created due to incorrect dosages (I.V. administered) and fatalities.

    EDTA & Ca-EDTA (Calcium EDTA) Chelation Therapy

    EDTA CHELATION THERAPY

    Chelation is the process by which a metal or mineral (such as lead, mercury, iron, arsenic, aluminum, etc.) is bonded to another substance-in this case an amino acid called EDTA (Ethylene diamine tetra acetic acid). It is a natural process, basic to life itself. During EDTA chelation therapy, the EDTA infusion bonds with unwanted metals in the body and quickly carries them away in the urine. EDTA Chelation therapy is a safe, effective alternative to drugs and surgeries and is used to treat many illnesses now known to be linked to the presence of toxic heavy metals. Illnesses such as heart disease, strokes, diabetes, circulatory disorders, neuropathies, Alzheimer's disease, atherosclerosis, and adverse reactions to many environmental pollutants. Traditional chelation therapy uses an intravenous drip, and is administered in the outpatient setting. The number of treatments vary based on each person's individual condition and/or goals of treatment. The average therapy is given one to three times a week for twenty to thirty treatments.

    EDTA chelation therapy for the detoxification for heavy metals has been in continuous use since the 1940s when it was introduced specifically for the treatment of lead poisoning. It was very quickly observed that as the metals were eliminated, not only did the signs and symptoms of lead poisoning abate, but problems related to the circulatory system like heart attacks, angina, strokes, and peripheral vascular disease also improved. For the past 50 years, well over one million people have received the intravenous form of EDTA chelation. As beneficial and life saving as this therapy has become, it is very expensive and very time-consuming, making it out of reach for most people.

    TYPES OF EDTA

    Why is Ca-EDTA so much better than other types of EDTA chelation therapy? According to Dr. Bruce Halstead, "The chemistry of all chelators is such that a change of pH can dramatically effect the process of chemical binding needed to chelate a mineral or metal. When you use a less effective chelator, such as Magnesium EDTA, you lose all chelating ability of the two most essential heavy metals: lead and mercury. Magnesium Di-Potassium EDTA has a dramatically lower chelating effectiveness than Calcium EDTA because both magnesium and potassium dramatically decrease the pH in the blood environment to which it is introduced. Any factor decreasing pH renders EDTA less effective. Once the pH is lowered more than 7.38, it is no longer chemically conducive to any bonding or chelating." (Dr. Halstead is well known as the "Father of Chelation Therapy".)

    Calcium EDTA (Ca-EDTA), or Calcium Disodium EDTA as it is also known, is Calcium Disodium combined with EDTA to form a sequestering agent that chelates other metals and unwanted substances such as cholesterol, from the blood stream. By itself, Calcium Disodium is an inert white crystalline calcium salt, which has shown to be the most effective combination with EDTA for the purpose of chelation. Calcium EDTA is also known as "edathamil" Calcium Disodium or Calcium Disodium "versenate", or Calcium Disodium Edetate. Disodium EDTA and Calcium Disodium EDTA have been approved by the FDA and other authorities as a food additive and dietary supplement. You will also note that Ca-EDTA is preferred and often used as a food additive because of its ability to sequester (chelate with) unwanted substances that discolor or destroy the food quality. Although Magnesium Disodium EDTA has been used in an estimated 1 million patients in IV form over the last 30 years, the recent trend has been to use the calcium form because it is easier on the kidneys. Although there are adherents of oral Magnesium Disodium EDTA, it also is not found to any great extent in the literature. Taken orally, the magnesium form is harder on the GI tract than the calcium form, causing an increased risk of diarrhea.

    Environmentalists warn us repeatedly that we live on a poisoned planet. Toxins from mercury, lead, aluminum, cadmium, iron, nickel, and about 20 more metallic minerals permeate the Earth's milieu. Heavy and light metals poison us by combining to create deleterious signs and symptoms often referred to collectively as Toxic Metal Syndrome. This syndrome, an indicator of serious systemic pathology, results in degenerative diseases which affect no less than 92-percent of the populations of Western industrialized nations, in particular, those people living in apartment high-rises and other polluted city dwellings. These poisoned people eventually come down with manifestations of degenerative illnesses such as heart and/or blood vessel deteriorations; pancreatitis; gout, rheumatoid arthritis or osteoarthritis; the syndromes of yeast, chronic fatigue, and/or irritable bowel; Alzheimer's disease, multiple sclerosis, Parkinson's disease, and many more which may be deadly, such as cancer.

    Although a poisoned person's bones remain toxic for life, excellent self-treatment exists to reduce or reverse most symptoms of illness in other body parts. First, get tested for the extent of toxicity, then neutralize metallic poisoning with a chelating agent such as Detoxamin. By applying the highly efficacious Detoxamin suppository containing EDTA, you remove toxic metal from cells all over the body. The self-administration is performed rectally before retiring so that as you sleep you are taking chelation therapy with EDTA. There is no need for intravenous infusions or quantities of nutritional supplements.

    Rectal chelation therapy does the job of detoxifying in a low-cost, convenient manner; it is an effective way to effuse EDTA through the bowel's walls and into your blood stream to clean toxic metals from all body cells.

    We find ourselves existing in a far more toxic and hostile environment than our bodies were designed to handle. Experts have shown that almost every health problem-from learning disorders to cancer and heart disease-is aggravated by the approximate 1,000-percent increase in lead levels in our bones. In 1999, it was reliably reported that hearts with some form of disease have 20,000 times more toxic heavy metals than healthy hearts. "Human exposure to heavy metals has risen dramatically in the last 50 years as a result of an exponential increase in the use of heavy metals in industrial processes and products." says Maile Pouls, Ph.D (Townsend Letter for Doctors and Patients, July 1999).

    A recently concluded "Body Burden" study by New York's Mount Sinai Hospital and the Environmental Working Group was reviewed by University of Oregon Professor Joseph Thornton: "It shows the universality of chemical contamination of people's bodies," Thornton said. All the studies "confirm the general message that everybody in our society has these chemicals building up. Some people have it worse than others, but everyone has it. No one is clean anymore." (From Being Careful Can't Keep Chemicals Out of Your Body, Miami Herald, February 1, 2003.)

    Today we know that about one out of every 2.5 Americans will get cancer. Ninety eight percent of cancer is caused by toxic chemicals. When 50-percent of all men and 33-percent of all women living now will die of cancer, something is terribly wrong. (Mortality from cancer was reduced by 90-percent during an 18-year study of 59 patients treated with Calcium-EDTA. Visit our website to read this study, and over 40 others proving the efficacy of Ca-EDTA chelation therapy and Detoxamin.) We will all function better and live longer if we lower the overall burden of toxic metals within ourselves. If you eat or breathe, you will probably benefit greatly from chelation therapy.


    WARNING: Synthetic Heavy Metals Chelators do carry risks. Please consult with your healthcare practitioner before undertaking Chelation Therapy. Your health is your own responsibility. It is far more sensible and safe to take a long term approach to chelation therapy (6 months to 1 year or longer) using low doses rather than trying to detox too fast in a short time frame using high dosages. The older you are the less efficient your kidneys will be and so age, amongst other factors, must be taken into consideration when chelating.

    Misuse can result in kidney damage, a sudden drop in blood pressure, low calcium levels in the blood and heart failure, which could be potentially fatal. The problem is regarding safe dosage levels versus the time period the chelator is administered over, which is why fast high dose I.V. chelation has caused rare fatalities. In case of uncertainty take a very small amount. 100 to 200 mg and wait for a week for any side effects before taking anymore.

    EDTA CHELATION SIDE EFFECTS

  • Upset stomachs, fatigue, headaches, nausea and vomiting. Taking EDTA may cause extreme tiredness for 2 to 3 days after taking it. The next day following an overnight chelation therapy with EDTA, mild upset stomach may occur. These symptoms are to be expected. You may or may not suffer any other side effects. Similar reactions may occur with with DMSA or DMPS chelation therapy.

  • Synthetic chelators bind with healthy minerals (e.g. calcium, manganese and zinc) and remove them so vitamin and liquid mineral supplementation is essential whilst doing chelation therapy.

  • Kidney Failure. There is a risk of overworking the kidneys as they filter minerals that are being pulled by the chelating agent causing possible permanent damage. Typically when incorrectly administered at too high a dose or without first testing kidney functioning.

  • Sudden drop in blood pressure causing dizziness or unconsciousness.


  • BAL CHELATION: Dimercaprol (INN) or British anti-Lewisite (abbreviated BAL), is a compound developed by British biochemists at Oxford University during World War II. It was developed secretly as an antidote for lewisite, the now-obsolete arsenic-based chemical warfare agent. Today, it is used medically in treatment of arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning. In addition, it has in the past been used for the treatment of Wilson's disease, a genetic disorder in which the body tends to retain copper. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

    Biochemical Function: Arsenic and some other heavy metals act by chemically reacting with adjacent thiol residues on metabolic enzymes, creating a chelate complex that inhibits the affected enzyme's activity. Dimercaprol competes with the thiol groups for binding the metal ion, which is then excreted in the urine. Dimercaprol is itself toxic, with a narrow therapeutic range and a tendency to concentrate arsenic in some organs. Other drawbacks include the need to administer it by painful intramuscular injection. Serious side effects include nephrotoxicity and hypertension.

    Dimercaprol has been found to form stable chelates in vivo with many other toxic metals including inorganic mercury, antimony, bismuth, cadmium, chromium, cobalt, gold, and nickel. However, it is not necessarily the treatment of choice for toxicity to these metals. Dimercaprol has been used as an adjunct in the treatment of the acute encephalopathy of lead toxicity. It is a potentially toxic drug, and its use may be accompanied by multiple side effects. Although treatment with dimercaprol will increase the excretion of cadmium, there is a concomitant increase in renal cadmium concentration, so that its use in case of cadmium toxicity is to be avoided. It does, however, remove inorganic mercury from the kidneys; but is not useful in the treatment of alkylmercury or phenyl mercury toxicity. Dimercaprol also enhances the toxicity of selenium and tellurium, so it is not to be used to remove these elements from the body.

    DTPA CHELATION: Pentetic acid or diethylene triamine pentaacetic acid (DTPA) is an aminopolycarboxylic acid consisting of a diethylenetriamine backbone with five carboxymethyl groups. The molecule can be viewed as an expanded version of EDTA and is used similarly. It is a white, water-soluble solid. The conjugate base of DTPA has a high affinity for metal cations. Thus, the penta-anion DTPA5- is potentially an octadentate ligand assuming that each nitrogen centre and each COO--group counts as a centre for coordination. The formation constants for its complexes are about 100 greater than those for EDTA. As a chelating agent, DTPA wraps around a metal ion by forming up to eight bonds. Transition metals, however, usually form less than eight coordination bonds. So, after forming a complex with a metal, DTPA still has the ability to bind to other reagents, as is shown by its derivative pendetide. For example, in its complex with copper(II), DTPA binds in a hexadentate manner utilizing the three amine centres and three of the five carboxylates.

    Like the more common EDTA, DTPA is mainly used for sequestering metal ions that otherwise decompose hydrogen peroxide, which is used to bleach pulp in paper making. Several million kilograms are produced for this purpose annually. Its chelating properties are useful in deactivating calcium and magnesium ions in hair products. DTPA is used in over 150 cosmetic products. Additionally, DTPA is used in MRI contrasting agents. DTPA improves MRI images by forming a complex with a gadolinium ion, which alters the properties of nearby water molecules.

    DTPA has been considered for treatment of radioactive materials such as plutonium, americium, and other actinides. In theory, these complexes are more apt to be eliminated in urine. It is normally administered as the calcium or zinc salt, since these ions are readily displaced by more highly charged cations. DTPA forms complexes with thorium(IV), uranium(IV), neptunium(IV), and cerium(III/IV).

    DTPA is also used as a chelate for aquarium plant fertilizer, specifically iron, an essential micronutrient typically needed in substantial quantities by all plants. Chelates are dissolved organic substances that bind to metals and prevent them from forming larger molecules through oxidation. FeDTPA is often sold under the name iron chelate 10 or 11-percent when used for the purpose of aquarium plant fertilization. Iron typically found in the aquarium water column has been converted into the ferric state (Fe+3) since it's in the presence of dissolved oxygen. However plants require iron in the ferrous state (Fe+2), therefore additional energy must be expended in order to extract the ferric iron from the water column and convert it to the ferrous form. When used to chelate iron fertilizer DTPA ensures that the iron is kept in the ferrous state (Fe+2) over time so it can be utilized by aquatic plants without expending valuable energy.

    Compounds that are structurally related to DTPA are used in medicine, taking advantage of the high affinity of the triaminopentacarboxylate scaffold for metal ions. In ibritumomab tiuxetan, the chelator tiuxetan is a modified version of DTPA whose carbon backbone contains an isothiocyanatobenzyl and a methyl group. In capromab pendetide and satumomab pendetide, the chelator pendetide (GYK-DTPA) is a modified DTPA containing a peptide linker used to connect the chelate to an antibody. Pentetreotide is a modified DTPA attached to a peptide segment. DTPA and derivatives are used to chelate gadolinium to form a MRI contrast agent, such as Magnevist. Technetium is chelated with DTPA for ventilation perfusion scan (V/Q scan) and renal scan.


    REFERENCES

  • Published in the August issue of Alternative & Complimentary Therapies (a magazine for doctors) and Published in Townsend Letter for Doctor's and Patients.
  • How To Detox Heavy Metals





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