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MoonDragon's Health & Wellness
Nutrition Basics


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  • Antioxidant Overview
  • Melatonin Antioxidant Description
  • Melatonin Antioxidant Uses, Health Benefits & Scientific Evidence
  • Melatonin Dosage Information
  • Melatonin Safety, Cautions & Interactions
  • Melatonin Supplement Products



    Antioxidants are vitamins, minerals, and other nutrients that protect and repair cells from damage caused by free radicals. Many experts believe this damage plays a part in a number of chronic diseases, including hardening of the arteries (atherosclerosis), cancer, and arthritis. Free radicals can also interfere with your immune system. So, fighting off damage with antioxidants helps keep your immune system strong, making you better able to ward off colds, flu, and other infections.

    Antioxidants are compounds that neutralize the cellular-damaging effects of free radicals. Free radicals are produced naturally in your body, but when you exercise hard, your body pumps out more free radicals. Environmental factors such as pollution, the sun, cigarette smoke, and herbicides can also spawn free radicals. The danger is that free-radical damage may lead to cancer. Antioxidants interact with and stabilize free radicals and may prevent some of the damage that free radicals otherwise might cause. As an active person, more antioxidants may help you slow the aging process, ward off cancer and stress, and promote good health.



    Melatonin is a hormone produced by the pineal gland, which is located beneath the brain. The pineal hormone melatonin is an efficient free radical scavenger and singlet oxygen quencher. Singlet oxygen is an excited oxygen molecule whose excessive discharge of energy causes damage to other body molecules. While most antioxidants work only in certain parts of certain cells, melatonin can permeate any cell in any part of the body.

    More important, melatonin is one of the few antioxidants that can penetrate the mitochondria, the cell's power plants, which produce energy. Melatonin does seem to protect the mitochondria from free radical damage. In laboratory experiments, melatonin supplementation has been found to extend the lifespan of mice. Other non-human laboratory studies have shown that supplemental melatonin can inhibit cancer growth, help modulate the immune system, and protect against degenerative diseases. Melatonin also stimulates the enzyme glutathione peroxidase, another antioxidant.


    Melatonin is one of the newest antioxidants to be discovered and has been described as the pacemaker of the aging clock in humans. It is released every night as part of our time-dependent biorhythms to help induce sleep and recuperation from fatigue. The hormone melatonin may also be the most efficient free radical scavenger that has thus far been identified. While most antioxidants work only in certain parts of certain cells, melatonin can permeate any cell in any part of the body. In animal experiments, it has been shown to protect tissues from an amazing array of assaults. Within the cell, melatonin provides special protection for the nucleus - the central structure that contains the DNA. Thus, it protects the structure that enables a damaged cell to repair itself.

    Melatonin is said to be 500 times more effective on free radicals than DMSO. It would be a supplement to your usual antioxidant vitamins and supplements. You can use melatonin as your main source of antioxidant since melatonin has effects on attacking free radicals in the brain while it protects the body against radiation, destroys toxins, and helps prevent or help cataracts. Melatonin has been show to have anticancer effects. Melatonin is nearly non-toxic and taking it with other antioxidants only helps.

    Synthesis and release of melatonin is stimulated by darkness and inhibited by light. But even without visual cues, the level of melatonin in the blood rises and falls on a daily (circadian) cycle with peak levels occurring in the wee hours of the morning. According to David Klein, PhD, a researcher in the NICHD's Laboratory of Developmental Neurobiology, melatonin is made in the pineal gland of the brain from another chemical, serotonin, with the help of two enzymes: arylalkylamine N-acetyl transferase (AA-NAT) and hydroxyindole-O-methyl transferase (HIOMT). AA-NAT appears to be the "melatonin rhythm enzyme," because a large increase in the activity of AA-NAT is responsible for the high levels of melatonin found in the brain and in the bloodstream at night. Similarly, low levels of melatonin formed during the day reflect low levels of this enzyme. This difference in day and night levels of melatonin is important for setting the body's circadian clock.

    However, this cycle tends to drift in people who are totally blind, often making them sleepy during the day and wide awake at night. Giving melatonin at bedtime has proved helpful in a number of sleep related cases.



    The hormone melatonin is naturally produced by the pineal gland, a cone-shaped structure in the brain. Melatonin penetrates cell membranes (particularly those in the brain) to provide protection against free radicals throughout all our cells. The body's pattern of melatonin production is similar to that of the other "anti-aging" hormones, human growth hormone (HGH) and dehyroepiandrosterone (DHEA). Throughout early life, melatonin is produced in abundance. Shortly before puberty, though, the production of melatonin begins to drop, and then continue to decline steadily as we age. Melatonin increases the production of immune system cells throughout the body, which is extremely important for people over age 40, who will suffer a progressive decline in immune function as part of the normal aging process. Melatonin promotes restful sleep, but it is also one of the most powerful antioxidants known. It crosses the blood/brain barrier to stimulate the immune system and aid the body in resisting cancer.


    Research has demonstrated that melatonin may have several profound long-term effects on the body. As one of the most powerful antioxidants ever discovered - with a greater range of effectiveness than vitamin C, vitamin E, or beta-carotene - melatonin helps prevent harmful oxidation reactions from occurring. In this way, melatonin may prevent the changes that lead to hypertension and heart attack, and may reduce the risk of certain kinds of cancer. Indeed, research has indicated that many age-related problems are caused by declining levels of melatonin, which leave the body less able to prevent and repair oxidative damage.

    Melatonin also has been found to stimulate the immune system; have a major role in the production of estrogen, testosterone, and possibly other hormones, helping to prevent cancers involving the reproductive system; and slow the growth of existing malignancies. Recent studies suggest that if melatonin is taken in the mornings, tumor growth may be stimulated, but if it is taken in the evenings, it has a retarding effect on tumor growth. In addition, as melatonin is secreted cyclically, in response to the fall of darkness at the end of each day, the hormone helps our bodies keep in sync with the rhythms of day and night. Thus, melatonin helps to regulate sleep.


    Melatonin is most commonly used to induce drowsiness and improve sleep patterns; however, numerous studies have shown that Melatonin protects against almost every disease associated with aging including cardiovascular disease, osteoporosis, age-associated immune impairment, and Alzheimer's and Parkinson's disease, as well as against aging itself. Another popular use of Melatonin is for easing the effects of jet lag.

    Research on melatonin continues, and with it, knowledge is increasing about the functions of melatonin in the body and the effects of melatonin supplementation. Both human research studies and anecdotal evidence indicate that melatonin supplements can be an effective and side-effect-free sleep aid both for adults suffering from insomnia and for children with autism, epilepsy, Down syndrome, cerebral palsy, and other problems that can cause sleep disorders.

    Animal and other laboratory research indicates that melatonin supplementation may help prevent age-related disorders, and perhaps extend life. Melatonin can be taken to ease PMS symptoms; stimulate the immune system; prevent memory loss, arteriosclerosis, and stroke; and treat cancer and Alzheimer's disease.


    Recent research on Melatonin is supporting the belief that it is a powerful anti-carcinogenic hormone. Dr. Russel Reite, author of Your Body's Natural Wonder Drug - Melatonin describes it as one of the most powerful antioxidants, and advocates its use for this reason, for free radical damage to the brain is known to be the cause of a large number of serious diseases such as Alzheimer's, Parkinson's, Down syndrome and muscular dystrophy. Vitamin E, the universal antioxidant, does not cross the blood/brain barrier to prevent oxidation. Melatonin does cross the blood/brain barrier.

    An article in Cancer Research, 1998 Vol. 18 Iss. 2B, pp 1329 to 1332 confirms that melatonin activates the immune system in Cancer patients. In a study of 31 patients, who failed to respond to other therapies, melatonin administered at 10 mg per day showed significant results, with 12 patients (39 percent) achieving disease stabilization after 3 months. None had adverse reactions. This study concluded melatonin plays a significant role in defending the body against the progression of cancer.

    Biological Rhythm Research, 1998, Vol. 29 Iss. 2 pp 121 to 128 reported that coronary heart disease patients secreted considerably less melatonin from their pineal glands than healthy individuals and their night time cortisol levels at night were considerably raised. Melatonin therapy would thus be advantageous for these patients.

    Neuroscience Letters, 1998, Vol. 247, Iss. 2 to 3, pp 131 to 134 reports that melatonin is a modulator of the immune system. 35 children suffering from tonsillitis and due for tonsillectomy were studied and given melatonin therapy, which restored their B-lymphocyte values. Further studies are being undertaken to determine melatonin's therapeutic role in the pathology of tonsils.

    And the mega-dosing with melatonin (up to 20 mg) prior to chemotherapy has been shown to reduce the damage to the bone marrow, the most severe side effect of this therapy.



    Standard dosage recommendations of Melatonin is one 1.5 to 5 mg tablet daily, taken 20 minutes before bedtime.

    Melatonin delays the aging process and improves sleep. Good for many disorders associated with aging. Always read product label directions before use. Melatonin should be taken two hours or less before bedtime. This schedule is designed to release the added hormone at the same time that natural production peaks. A sustained-release form is best if you frequently awaken after several hours' sleep; a sublingual form is best if you are very ill or suffer from malabsorption. When you awaken after melatonin-assisted sleep, you should feel refreshed - not tired or groggy. If you do experience grogginess, you should reduce the dosage. (To learn how you can maintain or increase your melatonin levels through daily routines, see below.

    Note: The appropriate dose can vary enormously from person to person. For example, you can find dosages of 1.2 mg, 1.5 mg and 3.0 mg as an example with supplements. Start off with the 1.2 mg dosage each night before bedtime, and work your way to larger doses if needed.


    As darkness falls at the end of each day, melatonin production rises. In the morning, when daylight hits the retina, neural impulses cause production of the hormone to slow. Clearly, light and darkness are the primary factors that set the rhythms of melatonin production. However, they are not the only factors involved. In fact, it has been found that a variety of regular daily routines can strengthen the rhythm of melatonin production. Here are a few simple ways in which you can help your body maintain high levels of this important hormone:
    • Eat regular meals. The rhythm of melatonin production is strengthened by regular daily routines. Keep you mealtimes as regular as possible to keep your body in sync with the rhythms of the day.

    • Keep your diet light at night. When melatonin production begins after nightfall, the digestive process is slowed. Thus, any heavy foods eaten close to bedtime may lead to digestive problems, which can make it difficult to sleep. To get the sleep you need, eat small, light meals in the late evening.

    • Avoid stimulants. Stimulants like coffee, tea, and caffeine-containing medications and colas can interfere with melatonin production by interfering with your sleep. As much as possible, eliminate these stimulants from your diet and lifestyle.

    • Avoid exercising late at night. Vigorous activity delays melatonin secretion. If you exercise in the morning, you will reinforce healthful sleeping habits that lead to regular melatonin production. For best results, do your morning exercise out of doors, in the morning light.



    Melatonin is one of the least toxic substances known. People have taken as much as 6 grams (600 to 3000 times the normal dosage) of the substance in carefully monitored studies with no sign of toxicity. Only four complaints regarding melatonin have been report to the FDA (USA's Food and Drug Administration). The only consistent side effect of high doses has been drowsiness and a slower reaction time. In the most extensive clinical trial to date a high dose of 75 milligrams (mg) of melatonin per day was given to 1400 women in the Netherlands for up to four years with no ill effects. The FDA reports that in the more than two years melatonin has been available for sale over-the-counter in the United States, no alarming side effects have been reported.

    According to one report, 10 percent of the users said the hormone did nothing for them with regards to sleep disorders, and another 10 percent complained of side effects such as nightmares, headaches, morning grogginess, mild depression, and low sex drive, weight gain, irritability, diminished brain function, and impaired athletic performance. In past studies, researchers have given people up to 600 to 3,000 times the usual doses - without causing any toxicity.

    Melatonin is depleted with age, lack of exposure to sunlight and disease, and reduced melatonin levels can result in serious diseases. It also depleted by exposure to electromagnetic radiation, especially in power utility company workers.

    In test-tube and animal experiments, researchers have found that it protects cells, strengthens the immune system and slows the growth of some tumors. Tests with laboratory mice suggest that melatonin might also reduce the effects of aging, but these tests results are very preliminary. One concern is that high doses, while causing no immediate harm, could have unknown long-term effects. Even one milligram, the smallest commercially available dose, is at least three times higher than the normal amount in the body.


    Melatonin should not be taken by people using certain antidepressants. This interaction between melatonin and certain antidepressants can cause a stroke or heart attack. If you are taking antidepressants, consult with your health care provider or pharmacy before using melatonin supplements to prevent interaction problems.

    Although no toxic levels of melatonin have been found, some researchers feel that certain people probably should not use this supplement until further information is available. Included in this category are:
    • Women who are pregnant or nursing should consult medical advice before using a melatonin supplement since no one knows how excessive exposure to the hormone might affect a fetus or infant.
    • People with severe allergies or autoimmune diseases should avoid melatonin could exacerbate such conditions by stimulating the immune system). People with immune-system cancers such as lymphoma or leukemia should avoid taking supplemental melatonin for the same reason.
    • Healthy children, who already produce it in abundance, should avoid taking supplemental melatonin.
    • Women trying to conceive should also think twice about taking the hormone, since high doses can act as a contraceptive.
    • Safety in people with severe liver or kidney disease is not known. Consult a health care practitioner before taking any supplements.

    If you have a medical condition you should always consult your health care provider first before taking melatonin.


  • Melatonin & Medical Conditions
  • Reference Center & Information on Melatonin
  • Health Benefits of Tart Cherry Juice: Melatonin & Antioxidants
  • Melatonin Abstracts
  • Medscape: Is Melatonin Safe For Children?

  • Books: ABCs of Hormones: What You Need to Know About Melatonin, Dhea, Sex Hormones, Hgh, Insulin, Thyroid, and More (Good Health Guides) By Jack Challem Books: Boost Your Vitality With Melatonin: Programming Your Internal Clock For Health & Well-being By Ingeborg Cernaj Books: The Melatonin Miracle: Nature's Age-Reversing, Disease-Fighting, Sex-Enhancing Hormone By Walter Pierpaoli, MD, William Regelson, Carol Colman Books: Melatonin By Russel J. Reiter, Jo Robinson Books: Melatonin: The Anti-Aging Hormone By Suzanne LeVert


  • Melatonin Supplement Products


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    From being a natural sleep regulator to providing the body with a potent anti-oxidant, a Melatonin supplement is a superior choice for those looking for better health and anti-aging nutrients. A good night's sleep can help restore your body, promote a healthy immune system and may help you maintain a healthy body weight. Not only does Melatonin help you sleep, it has also been shown to reduce anxiety. It does this by affecting neurotransmitters in the brain that are involved in relaxation and sleep. Health exports report that sleep is more that merely "down time" when the brain shuts off and the body rests. Adequate sleep is essential to overall health and performance and plays a role in the ability to learn, create memories, solve problems and maintain a healthy mental outlook. By contrast, researchers have found that lack of sleep can result in the mood swings and the inability to focus and react quickly.


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  • Nutrition Basics: Melatonin Supplement Information

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  • MoonDragon's Nutrition Basics Index
  • MoonDragon's Nutrition Basics: Amino Acids Index
  • MoonDragon's Nutrition Basics: Antioxidants Index
  • MoonDragon's Nutrition Basics: Enzymes Information
  • MoonDragon's Nutrition Basics: Herbs Index
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  • MoonDragon's Nutrition Basics: Mineral Introduction
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  • MoonDragon's Nutrition Basics: Dietary Supplements Introduction
  • MoonDragon's Nutrition Basics: Specialty Supplements
  • MoonDragon's Nutrition Basics: Vitamins Index
  • MoonDragon's Nutrition Basics: Vitamins Introduction


  • MoonDragon's Nutrition Basics: 4 Basic Nutrients
  • MoonDragon's Nutrition Basics: Avoid Foods That Contain Additives & Artificial Ingredients
  • MoonDragon's Nutrition Basics: Is Aspartame A Safe Sugar Substitute?
  • MoonDragon's Nutrition Basics: Guidelines For Selecting & Preparing Foods
  • MoonDragon's Nutrition Basics: Foods That Destroy
  • MoonDragon's Nutrition Basics: Foods That Heal
  • MoonDragon's Nutrition Basics: The Micronutrients: Vitamins & Minerals
  • MoonDragon's Nutrition Basics: Avoid Overcooking Your Foods
  • MoonDragon's Nutrition Basics: Phytochemicals
  • MoonDragon's Nutrition Basics: Increase Your Consumption of Raw Produce
  • MoonDragon's Nutrition Basics: Limit Your Use of Salt
  • MoonDragon's Nutrition Basics: Use Proper Cooking Utensils
  • MoonDragon's Nutrition Basics: Choosing The Best Water & Types of Water


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