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MoonDragon's Health & Wellness
Nutrition Basics

Antioxidants
HESPERIDIN

Bioflavonoid


For Informational Use Only
For more detailed information contact your health care provider
about options that may be available for your specific situation.





  • Hesperidin Description
  • Hesperidin Uses & Scientific Evidence
  • Hesperidin Dosage Information
  • Hesperidin Safety, Cautions & Interaction Information
  • Hesperidin Bioflavonoid Supplement Products




  • HESPERIDIN DESCRIPTION

    A BIOFLAVONOID & ANTIOXIDANT

    Hesperidin is a flavanone glycoside found abundantly in citrus fruits. Its aglycone form is called hesperetin. It should not be confused with hesperadin, which is an aurora inhibitor. Hesperidin's name is derived from the word "hesperidium", the kind of fruit produced by citrus trees. Hesperidin is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies.

    Hesperidin is a bioflavonoid that is vital in helping increase the strength of the blood vessels and regulating their permeability. This bioflavnoid protects Vitamin C from being destroyed by oxidation and allows the body to properly absorb and use Vitamin C. This bioflavonoid also assists Vitamin C in keeping Collagen in healthy condition. Wrinkling and sagging skin is caused by a breakdown of collagen. Hesperidin is a water-soluble nutrient found in high concentrations in citrus fruits and leafy green vegetables.





    HESPERIDIN USES, HEALTH BENEFITS & SCIENTIFIC EVIDIENCE

    Hesperidin is a natural substance found primarily in the pulps and rinds of citrus fruits. It is also available in supplement form and is classified as a bioflavonoid - a type of compound with antioxidant effects. It is touted as a natural remedy for a number of health problems and have beneficial effects on the blood vessels, including:
    • Allergies
    • Hemorroids
    • High Blood Pressure
    • Menopause Symptoms
    • Premenstrual Syndrome (PMS)
    • Varicose Veins

    Hesperidin is also said to improve circulation, reduce inflammation, and help prevent cancer.

    Hesperidin is useful in treating the complaints of menopause and in dealing with the viruses that cause herpes, the flu, and certain respiratory ailments. Hesperidin fights allergic reactions by blocking the release of histamine. It may also help reduce edema (accumulation of fluid) in the legs. Hesperidin deficiency has been linked to weaknesses in the walls of the blood vessels, pain and weakness in the hands and feet, and leg cramps at night. Having adequate amounts of Hesperidin in the body can help prevent hypertension, hemorrhages and ruptures in the capillaries and connective tissues. It also helps build a protective barrier against infections. It is thought that Hesperidin is effective in reducing hay fever and other allergies by inhibiting the release of histamine.

    Research on the health effects of Hesperidin is fairly limited. However, there is some evidence that Hesperidin may offer certain health benefits, although most of the studies are older. Various preliminary animal studies reveal novel pharmaceutical properties. Hesperidin reduced cholesterol and blood pressure in rats. In a mouse study, large doses of Hesperidin decreased b bone density loss. Another animal study showed protective effects against sepsis. In vitro and in laboratory research, Hesperidin has anti-inflammatory effects. It is also a potential sedative, possibly acting through opioid or adenosine receptors. Hesperidin exhibited pronounced anticancer activity against some selected human carcinoma cell lines. Some in vitro results applied only to the aglycone form. Hesperidin also showed potential to penetrate the blood-brain barrier in an in vitro model. A source of Hesperidin is 700 to 2,500 ppm in fruit of Citrus aurantium L. (Rutaceae) - Bitter Orange, Petitgrain.

  • Chronic Venous Insufficiency: This is a condition in which the veins do not efficiently return blood from the legs to the heart, chronic venous insufficiency is linked to problems like varicose veins, ankle swelling, and nighttime leg cramping. Supplements containing a combination of Hesperidin, extract of the herb butcher's broom, and ascorbic acid (a form of vitamin C) may help treat chronic venous insufficiency, according to a 2007 study published in International Angiology. The study involved 124 people with chronic venous insufficiency. Every day for eight weeks, all study members took two capsules of the hespiridin/butcher's broom/ascorbic acid formula. Starting in the second week of the study, participants showed significant improvements in their symptoms (including pain, cramps, and swelling). The study's authors suggest that the hespiridin/butcher's broom/ascorbic acid may help treat chronic venous insufficiency by producing beneficial effects in patients' blood vessels.

  • Hemorrhoids: Hesperidin is used to treat internal hemorrhoids, when used in combination with diosmin. the combination of hesperidin and diosmin seems to both significantly improve the symptoms of hemorrhoids and also keep hemorrhoid, once healed, from coming back. In a 1994 study from Angiology, a supplement containing a combination of hespiridin and diosmin (another antioxidant compound available in citrus fruits) was found to aid in the treatment of hemorrhoids. For the study, 100 patients suffering from a hemorrhoid attack were treated with either the hespiridin/diosmin combination or a placebo for seven days. Compared to the placebo group, members of the supplement group showed significantly greater improvement in symptoms.

  • Leg Ulcers: Hesperidin is used to treat leg ulcers caused by poor circulation, when used in combination with diosmin. Hesperidin, in combination with diosmin and a compression dressing, seems to improve healing of small ulcers (less than 10 centimeters) caused by poor blood circulation.

  • Lymphedema: Hesperidin may be considered for reducing arm swelling in lymphedema following breast cancer surgery.

  • Cancer: Hesperidin may offer anti-cancer benefits, according to a preliminary study published in Phytotherapy Research in 2010. In tests on human breast cancer and prostate cancer cells, the study's authors found that hesperidin inhibited the spread and growth of cancer cells.

  • Osteoporosis: Hesperidin shows promise for the prevention for postmenopausal osteoporosis, a 2003 study from the Journal of Nutrition suggests. In tests on mice, researchers discovered that a hesperidin-rich diet helped inhibit bone loss in animals whose ovaries had been removed.

  • High Cholesterol: Preliminary research indicates that a combination of Hesperidin and vitamin E may help keep cholesterol in check. In a 2001 study on rats (published in the International Journal for Vitamin and Nutrition Research), scientists found that supplementing the animals' high-cholesterol diets with hesperidin and vitamin E helped reduce cholesterol levels in their blood.


  • REFERENCES

    1. Hirata A, Murakami Y, Shoji M, Kadoma Y, Fujisawa S (2005). Kinetics of radical-scavenging activity of hesperetin and hesperidin and their inhibitory activity on COX-2 expression. Anticancer Res. 25 (5): 3367–74.
    2. Monforte MT, Trovato A, Kirjavainen S, Forestieri AM, Galati EM, Lo Curto RB (September 1995). Biological effects of hesperidin, a Citrus flavonoid. (note II): hypolipidemic activity on experimental hypercholesterolemia in rat. Farmaco 50 (9): 595–9.
    3. Ohtsuki K, Abe A, Mitsuzumi H, et al. (December 2003). Glucosyl hesperidin improves serum cholesterol composition and inhibits hypertrophy in vasculature. J. Nutr. Sci. Vitaminol. 49 (6): 447–50.
    4. Chiba H, Uehara M, Wu J, et al. (June 2003). Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice. J. Nutr. 133 (6): 1892–7.
    5. Kawaguchi K, Kikuchi S, Hasunuma R, Maruyama H, Yoshikawa T, Kumazawa Y (May 2004). A citrus flavonoid hesperidin suppresses infection-induced endotoxin shock in mice. Biol. Pharm. Bull. 27 (5): 679–83.
    6. Emim JA, Oliveira AB, Lapa AJ (February 1994). Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice. J. Pharm. Pharmacol. 46 (2): 118–22.
    7. Galati EM, Monforte MT, Kirjavainen S, Forestieri AM, Trovato A, Tripodo MM (November 1994). Biological effects of hesperidin, a citrus flavonoid. (Note I): antiinflammatory and analgesic activity. Farmaco 40 (11): 709–12.
    8. Loscalzo LM, Wasowski C, Paladini AC, Marder M (February 2008). Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines. Eur. J. Pharmacol. 580 (3): 306–13.
    9. Guzmán-Gutiérrez SL, Navarrete A (March 2009). Pharmacological exploration of the sedative mechanism of hesperidin identified as the active principle of Citrus sinensis flowers. Planta Med. 75 (4): 295–301.
    10. Al-Ashaal HA, El-Sheltawy ST Antioxidant capacity of hesperidin from citrus peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines. Pharm Biol. 2011 Mar;49(3):276-82.
    11. Youdim KA, Dobbie MS, Kuhnle G, Proteggente AR, Abbott NJ, Rice-Evans C (April 2003). Interaction between flavonoids and the blood-brain barrier: in vitro studies. J. Neurochem. 85 (1): 180–92.
    12. http://sun.ars-grin.gov:8080/npgspub/xsql/duke/plantdisp.xsql?taxon=276.





    HESPERIDIN DOSAGE INFORMATION

    FOODS & SUPPLEMENTS

    Hesperidin is a plant chemical that is classified as a bioflavonoid. It is found primarily in citrus fruits. People also use it as a medicine and dietary supplement. Hesperidin sources include Hyssop, Buchu leaf, Capsicum annuum (Bell pepper, Cherry Pepper, Cone Pepper, Green Pepper, Sweet Pepper, Paprika), Capsicum frutescens (Chili Pepper, Hot Pepper Cayenne Pepper, Tabasco), Bitter Orange (Petitgrain), Lemons, Citron, Grapefruit, Mandarin Oranges / Tangerines, Oranges, Limes, and other citrus species, Artichoke leaf, Spurge Laurel (Spurge Olive), Mentha canadensis L. (Cornmint, Field Mint, Japanese Mint), Mentha longifolia L. (Bibical Mint), European Pennyroyal, Spearmint, and other mint species, Masterwort, Rosemary, and Mullein.

    Hesperidin alone, or in combination with other citrus bioflavonoids (diosmin, for example), is most often used for blood vessel conditions such as hemorrhoids, varicose veins, and poor circulation (venous stasis). It is also used to treat lymphedema, a condition involving fluid retention that can be a complication of breast cancer surgery. Hesperidin may help blood vessels function better. It may also reduce inflammation. In addition to increasing vein and capillary strength, Hesperidin can reduce histamine release from mast cells by strengthening the cell membrane (mast cells are blood cells that contain granules of histamine and other substances).

    Hesperidin comes in various forms and is an ingredient in many products. While Hesperidin itself is not very water-soluble, hesperidin methyl chalcone (HMC) is highly water-soluble, allowing for greater absorption of the molecule in the gastrointestinal tract. As with all flavonoids, HMC is an antioxidant. Hesperidin also supports eye health and has blood vessel-stabilizing effects.

    A standard dosage of Hesperidin is between 10 mg and 100 mg per day depending on your body’s needs. For best results read and follow product label directions. The following doses have been studied in scientific research:

    TAKE HESPERIDIN BY MOUTH:

  • For the treatment of hemorrhoids inside the anus: 150 mg of Hesperidin plus 1350 mg of diosmin twice daily for 4 days, followed by 100 mg of hesperidin and 900 mg of diosmin twice daily for 3 days.
  • For preventing the return of hemorrhoids inside the anus: 50 mg of Hesperidin plus 450 mg of diosmin twice daily for 3 months.
  • For the treatment of leg ulcers caused by poor blood circulation (venous stasis ulcers): a combination of 100 mg of Hesperidin and 900 mg of diosmin daily for up to 2 months.





  • HESPERIDIN SAFETY, CAUTIONS & INTERACTION INFORMATION

    DEFICIENCY

    A deficiency in Hesperidin may result in varicose veins, a tendency to bruise and bleed easily, and/or the appearance of purplish spots on the skin.

    SAFETY CONCERNS

    Hesperidin is possibly safe for most people when used orall used for less than six months to a year. The safety of using it for a longer period of time is unknown.

    Hesperidin may trigger some side effects include stomach/abdominal pain, nausea and upset, diarrhea, and headache.

    Consult a health care practitioner or midwife while pregnant or breastfeeding before using hesperidin. Not enough is known about the use of hesperidin during pregnancy and breastfeeding.

    There currently is no information available about hesperidin interactions. However, it may be unsafe for people taking certain medications (including anticoagulants, blood pressure drugs, and calcium channel blockers). Therefore, it is important to consult your health care provider if you are considering using hesperidin in combination with other medications. In addition, hesperidin may be unsafe for people with blood disorders.





    HESPERIDIN BIOFLAVONID SUPPLEMENTS & RELATED PRODUCTS

  • Citrus Bioflavonoid Products
  • Hesperidin Bioflavonoid Products

  • Quercetin Biorflavonoid Products
  • Rutin Bioflavonoid Products


  • QUALITY SUPPLIES & PRODUCTS


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    HESPERIDIN BIOFLAVONOID SUPPLEMENT PRODUCTS

    Hesperidin is a naturally occurring flavonoid which can be found in citrus rinds. Citrus bioflavonoids possess antioxidant properties have been shown to positively impact normal capillary integrity.

    HERBSPRO PRODUCTS

    HerbsPro: VeinFactors, Varicose Vein Complex For Normal Vein Function, Futurebiotic, 90 Caps (67625)
    VeinFactors supports normal vein function with patented extracts, traditional compounds and natural co-factors. Diosmin and Hesperidin are naturally-occurring flavonoids which can be found in citrus rinds. Widely used in Europe where it has been clinically studied, Diosmin has been shown to help maintain blood vessel tone and support healthy leg circulation. VeinFactors Diosmin is "micronized," reducing nutrient particle size for better absorption and efficacy. Venocin is extracted from Horse Chestnut seed and is standardized for 20% escin, a triterpenic saponin mixture that helps normalize swelling while protecting healthy veins. Centellin is extracted from Gotu Kola and is standardized for 8% total triterpenes, which research shows may be beneficial for normal vein function. Soluble Citrus Extract contains nine different flavonoids from natural citrus extract. Citrus bioflavonoids possess antioxidant properties and have been shown to positively impact normal capillary integrity. Butcher's Broom extract has been reported to improve healthy vein strength and tone. Whole Horse Chestnut, Butcher's Broom and Citrus powder provide natural whole plant co-factors that nature created and have been added to provide a complete venous support formula.
    HerbsPro: Diosmin, Baywood, 500 mg, 60 Tabs (69321)
    Baywood's Diosmin Caps combine Diosmin and Hesperidin to make the most complete, effective combination formula for supporting healthy veins. Diosmin and Hesperidin are two natural citrus bioflavonoids. Both have anti-inflammatory and antioxidant activity and support over-all cardiovascular health, in addition to the cosmetic benefits of reducing the appearance of varicose veins and spider veins. Diosmin and Hesperidin are used widely in Europe for decreasing the appearance of varicose veins and spider veins, and also hemmorhoids. Hesperidin is the predominant flavonoid in lemons and oranges. The peel and membranous parts of these fruits have the highest hesperidin concentrations. Hesperidin is classified as a citrus bioflavonoid. Hesperidin, Diosmin and other flavonoids thought to reduce capillary permeability and to have anti-inflammatory action were collectively known as vitamin P. These substances, however, are not vitamins and are no longer referred to, except in older literature, as vitamin P.
    HerbsPro: Citrus Bioflavonoid Complex, Country Life, 500 mg, 250 Tabs (37098)
    Hypoallergenic/Vegetarian/Kosher Contains the naturally occurring flavonones Hesperidin and Eriocitrin. A Special Combination of Lemon, Orange and Grapefruit Bioflavonoids with Rutin.
    HerbsPro: Hy-C Tablets With Bioflavonoids, Rutin, Hesperidin & Rose Hips, Solgar, 600 mg / 100 mg, 250 Tabs (36502)
    Solgars HY-C offers 600 mg of pure Vitamin C combined with natural citrus bioflavonoids, rutin and hesperidin, which may enhance the absorption and utilization of Vitamin C. Vitamin C is a water-soluble nutrient with revered antioxidant and immune supportive properties. Combined with 175 mg natural bioflavonoids and 25 mg of rose hips, each single tablet serving of HY-C offers synergistic antioxidant support to combat cell-damaging free radicals which can cause premature aging.
    HerbsPro: Citrus Bioflavonoids Plus Hesperidin, Natural Factors, 650 mg, 90 Caps (83869)
    Citrus Bioflavonoids plus Hesperidin is derived from citrus fruit peels, which is an abundant source of bioflavonoids. Although hesperidin is part of the bioflavonoid complex, it is so important that extra amounts are added to ensure high levels. Bioflavonoids are brightly-coloured substances that are found in fruits and vegetables, and are typically a companion to vitamin C. Bioflavonoids are essential for the proper absorption of vitamin C and have been shown to have antioxidant properties, increase capillary strength and keep collagen healthy.
    HerbsPro: Bioflavonoids, Now Foods, 700 mg, 100 Caps (67788)
    Citrus Bioflavonoid Caps contain 30% total bioflavonoids as Hesperidin. There are many varieties of bioflavonoids available and ours includes a number of flavonols, flavones, and flavanones including: Hesperidin, Eriocitrin, Naringen, Naringenin, and Quercetin.
    HerbsPro: Mega Bio-C Formula, BlueBonnet Nutrition, 90 VCaps (100592)
    Mega Bio-C Formula Vcaps provide 750 mg of buffered vitamin C from pure calcium ascorbate with rutin, plus 750 mg of citrus bioflavonoids, including hesperidin, from fresh oranges, lemons, tangerines, grapefruits and limes. Available in easy-to-swallow vegetable capsules for maximum assimilation and absorption.
    HerbsPro: Mega Bio-C Formula, BlueBonnet Nutrition, 180 VCaps (100593)
    Mega Bio-C Formula Vcaps provide 750 mg of buffered vitamin C from pure calcium ascorbate with rutin, plus 750 mg of citrus bioflavonoids, including hesperidin, from fresh oranges, lemons, tangerines, grapefruits and limes. Available in easy-to-swallow vegetable capsules for maximum assimilation and absorption.
    HerbsPro: Bioflavonoids Complex, FoodScience of Vermont, 1000 mg, 60 Tabs (15153)
    A bioflavonoid complex supplement with hesperidin, rutin, and bromelain. Bioflavonoids enhance the effectiveness of Vitamin C. Bioflavonoids support capillary strength and proper vascular function.
    HerbsPro: C-1000 Plus Bioflavonoids, BlueBonnet Nutrition, 180 Caplets (100589)
    C-1000 mg Plus Bioflavonoids Caplets provide 1000 mg of high potency vitamin C from pure L-ascorbic acid, 100 mg of rutin and 500 mg of citrus bioflavonoids, including hesperidin, from fresh oranges, lemons, tangerines, grapefruits and limes. Available in easy-to-swallow caplets for maximum assimilation and absorption.
    HerbsPro: Citrus Bioflavonoid Complex, Country Life, 1000 mg, 250 Tabs (37096)
    Hypoallergenic/Vegetarian/Kosher Contains the naturally occurring flavonones Hesperidin and Eriocitrin. A Special Combination of Lemon, Orange and Grapefruit Bioflavonoids with Rutin.
    HerbsPro: Varicose Veins Lotion, Reviva, 8 oz. (35493)
    Varicose Veins & Deeper Spider Veins Lotion with Vitamin P & Horse Chestnut - A stronger Vitamin P formula with hesperidin and horse chestnut added, for deeper veins on legs. Also aids circulation to combat swelling of ankles and lower leg. Aids circulation and helps strengthen veins. Helps diminish vein appearance once varicose veins exist on the legs, they will not improve without therapy. Walking and massage are helpful to move blood out of the veins. Lightly massage legs daily with our new Varicose Veins Lotion not only aids circulation, but can work wonders in helping strengthen veins and diminish their appearance.


    KALYX PRODUCTS

    Kalyx: Varicose Vein Lotion, Reviva Labs, 8 fl oz: K
    For All Skin Types. Aids Circulation, Helps Strengthen Veins & Diminish Vein Appearance. Lightly massaging legs daily with their Varicose Veins Lotion not only aids circulation, but can also strengthen vein walls to help prevent problems as well as diminish appearance of existing varicose veins. With Vitamin P (Rutin and an exclusive blend of Citrus Bioflavonoids featuring Hesperidin), plus Horse Chestnut, Grapeseed Extract and more. It is Reviva Lab's solution to this very complex skin problem.


    AMAZON PRODUCTS

    Amazon: Hesperidin Supplement Products

  • Nutrition Basics: Hesperidin Bioflavonoid Information






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