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MoonDragon's Health & Wellness
Nutrition Basics

Antioxidants
COENZYME Q-10

(CoQ10; Ubiquinone)


"For Informational Use Only"
For more detailed information contact your health care provider
about options that may be available for your specific situation.





  • Coenzyme Q-10 Antioxidant Description
  • Coenzyme Q-10 Uses, Health Benefits, & Scientifc Evidence
  • Coenzyme Q-10 Dosage Information
  • Coenzyme Q-10 Safety, Cautions, & Interactions
  • Coenzyme Q-10 Supplement Products




  • COENZYME Q-10 ANTIOXIDANT DESCRIPTION

    ANTIOXIDANT CLASSIFICATIONS

    Antioxidants are generally classified into two broad categories - water soluble (hydrophilic) and lipid soluble (hydrophobic). Your body needs both types of antioxidants because each one targets different types of cells and tissues for free radical scavenging.

    Water soluble antioxidants are present in aqueous fluids, such as blood and intracellular and extracellular fluids. They react with oxidants in the cell cytosol (fluid portion of cytoplasm) and the blood plasma and helps repair the interior of walls. Examples of water soluble antioxidants include vitamin C, glutathione, and catechins. The antioxidants anthocyanins, polyphenols, resveratrol) are water-soluble antioxidants.

    Lipid soluble antioxidants are localized to cellular membranes and lipoproteins. They protect cell membranes from lipid peroxidation. Examples of lipid-soluble antioxidants include vitamins E, A, and beta carotene. Both Astaxanthin and Ubiquinol contain lipid-soluble antioxidants. Lipid-soluble Astaxanthin helps repair fat/cell membranes and lipid-soluble Ubiquinol acts as an antioxidant recycler for vitamins C and E.

    To fight and help neutralize free radicals, you need both types of antioxidants from as many sources as possible. When taken together, the efficacy of water- and lipid-soluble antioxidants is enhanced even more. Each type of antioxidant has its own special function in helping repair and protect your cells from free radical damage.

    COENZYME Q-10 ANTIOXIDANT

    Coenzyme Q-10 was discovered by Dr. Frederick Crane of Wisconsin in 1957, and studied by numerous scientists, one of which was Dr. Peter Mitchell of England, who won a Nobel Prize in 1978 for unraveling the mechanism of CoQ10 function in energy production. Lars Ernster of Sweden, enlarged upon CoQ10's importance as an antioxidant and free radical scavenger. Professor Karl Folkers went on to receive the Priestly Medal from the American Chemical Society in 1986 and the National Medal of Science from President Bush in 1990 for his work with CoQ10 and other vitamins.

    Coenzyme Q-10, also known as CoQ10, is an antioxidant that is structurally similar to vitamin E. It also plays a crucial role in the generation of cellular energy, is a significant immunologic stimulant, increases circulation, has anti-aging effects, and is beneficial for the cardiovascular system. Also known as ubinquinone (from quinone, a type of coenzyme, and ubiquitous, because it exists everywhere in the body), coenzyme Q-10 is found in highest concentrations in the heart, followed by the liver, kidney, and pancreas. Your body makes CoQ10 and your cells use it to produce energy your body needs for cell growth and maintenance. Within the mitochondria, the cells' energy-production centers, Coenzyme Q-10 helps to metabolize fats and carbohydrates. It also helps to maintain the flexibility of cell membranes. It also functions as an antioxidant, which protects the body from damage caused by harmful molecules called free radicals. Coenzyme Q-10 help enzymes work to digest food and perform other body processes, and they help protect the heart and skeletal muscles. Other names for CoQ10 are Q10 and Ubidecarenone.

    In Japan, Coenzyme Q-10 has been approved for use in treating congestive heart failure. Various research reports suggest that coenzyme Q-10 also may be beneficial in treating cancer, AIDS, muscular dystrophy, allergies, gastric ulcers, myopathy, peridontal disease, diabetes, and deafness. CoQ10 is available in the United States as a dietary supplement.

    Natural dietary sources of Coenzyme Q-10 include meats, such as beef, particularly organ meats such as heart, liver and kidney, as well as peanuts, soy oil, sardines, mackerel and spinach. To put this into a perspective view, one pound of sardines, two pounds of beef or two and a half pounds of peanuts, provide 30 mg of Coenzyme Q-10.

    COENZYME Q-10 & AGING

    The challenge you face as you age is that your body levels of CoQ10 continue to diminish. In addition, your capability to convert CoQ10 to ubiquinol also declines. It becomes more and more difficult for you to produce the ubiquinol you need due to:
    • Increased metabolic demand.
    • Oxidative stress.
    • Insufficient dietary CoQ10 intake.
    • Deficiency of factors required for biosynthesis and ubiquinol conversion.
    • Potential effects from illness and disease.
    • Age-related changes in your genes.
    • And any combination of these factors.

    Some reports say your CoQ10 level decline becomes apparent as early as your 20's. Not everyone needs Ubiquinol formula (an active form of CoQ10). If you are under 25 years of age, your body should absorb regular CoQ10 just fine. In fact, research studies show that younger people do not absorb Ubiquinol as well as older people. There are regular CoQ10 formulas and Ubiqinol-based CoQ10 formulas. To sum it up, regular CoQ10 for those under 25 years old and Ubiquinol if you are over 25 has been recommended by some health care practitioners. So if you are young, sticking to a regular formula is good sense.

    For those older, trying a supplement may be a good choice. Your added benefits from the Ubiquinol formula can be significant as you...
    • Potentially absorb more CoQ10 - as shown in studies by enhanced blood plasma levels.
    • Become less dependent on your body to convert ubiquinone to ubiquinol. In the plasma of healthy humans, more than 90 percent of CoQ10 exists in the reduced form (ubiquinol).
    • Absorb CoQ10 that is already in the active state your body needs.
    • Receive the reduced (unoxidized) form of CoQ10 for added cellular energy.
    • Get a strong first stage defense against oxygen free radicals to help you reduce the typical signs of aging and optimize your health.

    CoQ10 and ubiquinol supplements can help you in many different ways to complement your healthy diet and energize your life.

  • Help you produce more energy for your cells.
    • Act as a catalyst in your body's various chemical reactions, leading to the production of energy.
    • Ignite your body's engine by jump-starting energy production in your cells.
    • You will enjoy your new-found energy and stamina levels.

  • Boost your heart health.
    • Help strengthen your overall cardiovascular system.
    • Help maintain and balance the critical energy level needed in your body's most vital muscle - your heart.
    • If you are using a statin medication, you may need to take a CoQ10 supplement to replenish your CoQ10 levels.

  • Help you maintain blood pressure levels within the normal range.
    • Promote healthy blood circulation in your body and a more efficient heart.
    • Research indicates maintaining proper levels of CoQ10 can help you maintain normal blood pressure levels.
    • Just by knowing you are taking more steps to take control of your health, you could feel more relaxed and less stressed out.

  • Help you reduce the signs of normal aging.
    • Help you potentially feel more alert and responsive.
    • By keeping blood levels high in CoQ10, help you maintain your vitality.
    • Support healthy gums and help maintain normal blood sugar levels.
    • Support muscle recovery from intensive workouts and promotes normalization of your weight.

  • Provide a boost to your immune system.
    • Help promote your healthy immune system.
    • Help support your immune system by providing a defense against free radicals.

  • Act as an antioxidant to help protect you from free radicals.
    • Provide your body with added defense against oxidation stress to your cells, tissues, and organs.
    • Help recharge other antioxidant nutrients to their active states - and keep them working for you.

  • Support your nervous system,
    • Help promote an active mind.
    • Your brain is one of the most active organs in your body and requires uninterrupted energy.
    • Help you deal with all of life's challenges and healthy decision making.





    COENZYME Q-10 USES, HEALTH BENEFITS, & SCIENTIFIC EVIDENCE

    ANTIOXIDANT BENEFITS

    Coenzyme Q10 is a powerful antioxidant that makes your heart strong and produces energy. In the part of a cell responsible for the production of energy called mitochondria, CoQ10 plays a key role in the production of this cell. CoQ10 is synthesized in all tissues. In healthy individual normal levels are maintained both by intake and by the bodyís synthesis of Coenzyme Q10. Numerous researches and clinical trials have been conducted that demonstrate the health benefits of taking CoQ10 some of which are, improved cardiovascular function and blood circulation, reduced problems associated with poor heart function, increased energy level and less fatigue, lowered blood pressure, reduced angina, and it is a strong anti-oxidant and anti-aging nutrient. Coenzyme Q10 may also help prevent or slow Alzheimer and Parkinsonís diseases. Taking other antioxidants in addition to CoQ10 will increase health benefits. One of the best-known effects of this compound is its antioxidant qualities as well as the control it exercises on the flow of oxygen within cells, assistance with cardiovascular functioning, the production of energy, its assistance with absorption of other nutrients as well as its immune boosting properties.

    In 2002 the Archives of Neurology reported that a double blind trial published that year on October 15th showed that Coenzyme Q10 appears to slow the progression of Parkinson disease (PD). This trial suggested that CoQ10 could slow the rate of deterioration in PD.

    The American College of Cardiology in 2005 at the 54th Annual Scientific Session reported this finding on CoQ10: Patients with significant myopathy who are taking statin therapy have a significant decrease in myopathic pain after 30 days of supplementation with Coenzyme Q10.

    Patricia Kelly, DO, Associate Professor of Medicine, University Hospital Medical Center, Stony Brook, New York also did some studies on CoQ10. The researchers conducted the present trial to determine if coenzyme Q10 supplementation would improve muscle related adverse effects in patients on statins. Dr. Kelly stated, "If Coenzyme Q10 supplementation were effective in reducing the symptoms of myopathy associated with statin use, it would be possible for patients to retain the beneficial effects of cholesterol lowering while reducing significant side effects," Pain improved in three of 20 Vitamin E patients and 18 of 21 Coenzyme Q10 patients.

    Many claims are made about CoQ10. It is said to help heart failure and cancer. Some people take it to help reduce the effects certain medicines can have on the heart, muscles, and other organs. If you have heart failure, talk to your health care provider before you take any supplement. There is no strong evidence that vitamins or other supplements can help treat heart failure. They are used along with medical heart failure treatments, not instead of treatment. But you may still hear about CoQ10 supplements and heart failure. CoQ10 has not been shown definitely to relieve heart failure symptoms. Only some of the studies of coenzyme Q10 showed that it helps heart failure symptoms. In 1961, scientists saw that people with cancer had little CoQ10 in their blood. They found low CoQ10 blood levels in people with myeloma, lymphoma, and cancers of the breast, lung, prostate, pancreas, colon, kidney, and head and neck. Some research has suggested that CoQ10 helps the immune system and may be useful as a secondary treatment for cancer. CoQ10 may keep the antitumor drug doxorubicin from hurting the heart. Three studies examined the use of CoQ10 along with conventional treatment for cancer. The three studies contained a total of 41 women with breast cancer. In each study, the women improved.

    INFORMATION & EDUCATION

  • NINDS.NIH.gov: Coenzyme Q-10 Slows Functional Decline in Parkinson's Disease
  • Cancer.gov: National Cancer Institute & Coenzyme Q-10

  • Amazon.com Books: The Coenzyme Q-10 Phenomenon By Stephen T. Sinatra, MD
    Amazon.com Books: Coenzyme Q-10: All-Around Nutrient for All-Around Health! Latest Research As a Heart Strengthener, Energy Promoter, Aging Fighter and Much More By Beth M. Ley-Jacobs
    Amazon.com Books: Coenzyme Q-10 and The Heart By Stephen T. Sinatra
    Amazon.com Books: User's Guide to Coenzyme Q-10: Don't Be a Dummy. Become an Expert on What Coenzyme Q-10 Can Do for Your Health By Martin Zucker
    Amazon.com Books: The Miracle Nutrient: Coenzyme Q-10 By Emile G. Bliznakov, MD, Gerald L. Hunt
    Amazon.com Books: All About Coenzyme Q-10 (Frequently Asked Questions) By Ray Sahelian, Jack Challem
    Amazon.com Books: Coenzyme Q-10: Nature's Heart Energizer By Ray Sahelian





    COENZYME Q-10 DOSAGE INFORMATION

    SUPPLEMENT FORMS

    Read product label directions before use. If you have any questions, contact your health care provider before using.

    Coenzyme Q-10 is available in many forms, capsule, tablets, softgels and chewable form.

    To improve absorption, take it with some type of oil or fat. Olive oil is the most recommended oil and peanut butter for fat.

    It is also best to take your dosage with meals.





    COENZYME Q-10 SAFETY, CAUTIONS, & INTERACTIONS

    SAFETY CONCERNS

    There are no known side effects associated with Coenzyme Q-10 when taken in normal dosages.

    Taking 100 mg a day or more of CoQ10 has caused mild insomnia in some people.

    Research has detected elevated levels of liver enzymes in people taking doses of 300 mg per day for long periods of time. Liver toxicity has not been reported.

    In extreme doses such as 600 to 1200 mg per day have reported side effects that include rashes and skin reactions, nausea, upper abdominal pain, diarrhea, dizziness, sensitivity to light, irritability, headache, heartburn, and fatigue.

    Medications for high cholesterol (statins) and medicines that lower blood sugar cause a decrease of CoQ10 levels and reduce the effects of CoQ10 supplements. CoQ10 can reduce the body's response to the blood thinner (anticoagulant) medicine warfarin (Coumadin) and can decrease insulin requirements in people with diabetes.

    People suffering from congestive heart failure and taking Coenzyme Q-10 should NOT stop taking it suddenly since sudden withdrawal may intensify the symptoms of this disease.

    As always, never self-diagnose. See your health care provider before you make any decisions about your health and well-being.

    A NOTE ABOUT DIETARY SUPPLEMENTS

    The U.S. Food and Drug Administration (FDA) does not regulate dietary supplements in the same way it regulates medicines. A dietary supplement can be sold with limited or no research on how well it works or on its safety. Always tell your health care provider if you are using a dietary supplement or if you are thinking about combining a dietary supplement with your conventional medical treatment. It may not be safe to forgo your conventional medical treatment and rely only on a dietary supplement. This is especially important for women who are pregnant or breast-feeding. When using dietary supplements, keep in mind that like conventional medicines, dietary supplements may cause side effects, trigger allergic reactions, or interact with prescription and nonprescription medicines or other supplements you might be taking. A side effect or interaction with another medicine or supplement may make other health conditions worse. Always tell your health care provider or pharmacist about all dietary supplements you are taking. The way dietary supplements are manufactured may not be standardized. Because of this, how well they work or any side effects they cause may differ among brands or even within different lots of the same brand. The form of supplement that you buy in health food or grocery stores may not be the same as the form used in research. Other than for vitamins and minerals, the long-term effects of most dietary supplements are not known.





    COENZYME Q-10 SUPPLEMENTS & RELATED PRODUCTS

  • Coenzyme Q-10 Supplement Products


  • QUALITY PRODUCTS & SUPPLEMENTS



    COENZYME Q-10 (COQ10 / UBIQUINONE) SUPPLEMENT PRODUCTS

    STARWEST BOTANICALS PRODUCTS

    Starwest Botanicals: Coenzyme Q-10 (Ubiquinone), 30 mg, 100 Softgels
    Starwest Botanicals: Coenzyme Q-10 (Ubiquinone), 30 mg, 500 Softgels


    HERBSPRO PRODUCTS

    HerbsPro: Coenzyme Q-10, Deva Vegan Vitamins, 25 mg, 60 Tabs (86837)
    HerbsPro: CoQ10, Nutricology Allergy Research Group, 30 mg, 30 Caps (38746)
    HerbsPro: CoQ10, Natrol, 30 mg, 60 Caps (16601)
    HerbsPro: CoQ10, Enzymatic Therapy, 30 mg, 60 Softgels (12672)
    HerbsPro: CoQ10, Now Foods, 30 mg, 90 Softgels (69487)
    HerbsPro: Mega CoQ10, TwinLab, 30 mg, 100 Caps (19752)
    HerbsPro: Coenzyme Q10, Source Naturals, 30 mg, 120 Softgels (6288)
    HerbsPro: CoQ10 With Vitamin E, Now Foods, 50 mg, 50 Softgels (68014)
    HerbsPro: CoQ10, Natures Answer, 50 mg, 60 Softgels (35210)
    HerbsPro: CoQ10, Natrol, 50 mg, 60 Caps (16602)
    HerbsPro: CoQ10, Nutricology Allergy Research Group, 50 mg, 75 Caps (38747)
    HerbsPro: CoQ10 With Vitamin E, Now Foods, 50 mg, 100 Softgels (68013)
    HerbsPro: CoQ10, Enzymatic Therapy, 50 mg, 120 Softgels (69269)
    HerbsPro: CoQ10 With Vitamin E, Now Foods, 50 mg, 200 Softgels (68012)
    HerbsPro: CoQ10, Enzymatic Therapy, 60 mg, 60 Tabs (69255)
    HerbsPro: CoQ10, Now Foods, 60 mg, 60 VCaps (68004)
    HerbsPro: CoQ10, Now Foods, 60 mg, 180 VCaps (68003)
    HerbsPro: Coenzyme Q10, Source Naturals, 75 mg, 120 Caps (6295)
    HerbsPro: CoQ10, 100% Natural, Healthy Origins, 100 mg, 30 Softgels (50289)
    HerbsPro: CoQ10, Now Foods, 100 mg, 50 Softgels (67985)
    HerbsPro: CoQ10, 100% Natural, Healthy Origins, 100 mg, 60 Softgels (50290)
    HerbsPro: CoQ10 Chewmelt, FoodScience of Vermont, 100 mg, 60 Tabs (61526)
    HerbsPro: CoQ10, Doctors Best, 100 mg, 60 Softgels (69111)
    HerbsPro: CoQ10, Deva Vegan Vitamins, 100 mg, 60 Tabs (86888)
    HerbsPro: Coenzyme Q10, Source Naturals, 100 mg, 90 Softgels (6278)
    HerbsPro: CoQ10, Country Life, 100 mg, 120 Softgels (87967)
    HerbsPro: CoQ10, Now Foods, 100 mg, 150 Softgels (67984)
    HerbsPro: CoQ10, 100% Natural, Healthy Origins, 100 mg, 150 Softgels (50291)
    HerbsPro: CoQ10, Natures Answer, 120 mg, 30 Softgels (35206)
    HerbsPro: Coenzyme Q10, Ultra Potency, Source Naturals, 125 mg, 60 Caps (6283)
    HerbsPro: CoQ10, Now Foods, 150 mg, 100 VCaps (67991)
    HerbsPro: CoQ10, 100% Natural, Healthy Origins, 200 mg, 30 Softgels (72361)
    HerbsPro: CoQ10, 100% Natural, Healthy Origins, 200 mg, 60 Softgels (72362)
    HerbsPro: CoQ10, Garden of Life RAW, 200 mg, 60 VCaps (94346)
    HerbsPro: CoQ10, Now Foods, 200 mg, 60 VCaps (71684)
    HerbsPro: CoQ10, 100% Natural, Healthy Origins, 200 mg, 150 Softgels (72363)
    HerbsPro: CoQ10, 100% Natural, Clinical Strength, Healthy Origins, 300 mg, 60 Softgels (50293)
    HerbsPro: CoQ10, Now Foods, 400 mg, 30 Softgels (68000)
    HerbsPro: Coenzyme Q10, Source Naturals, 400 mg, 60 Softgels (75198)
    HerbsPro: CoQ10, 100% Natural, Healthy Origins, 400 mg, 60 Softgels (72360)
    HerbsPro: CoQ10, Now Foods, 400 mg, 60 Softgels (68001)
    HerbsPro: CoQ10 Clinical Strength, Healthy Origins, 400 mg, 150 Softgels (74848)
    HerbsPro: CoQ10, Now Foods, 600 mg, 60 Softgels (69058)
    HerbsPro: CoQ10 Liquid, Now Foods, 1 fl. oz. (71713)
    HerbsPro: CoQ10 Liquid, Dynamic Health Labs, 50 mg, 8 fl. oz. (72834)
    HerbsPro: CoQ10 Pure Powder, Now Foods, 1 oz. (68006)
    HerbsPro: CoQ10 & Vitamin E Lozenges, Now Foods, 200 mg, 90 Lozenges (67994)
    HerbsPro: CoQ10 Wrinkle Defense Skin Serum, Avalon Organics, 0.55 oz. (14044)
    HerbsPro: CoQ10 Wrinkle Defense Skin Creme, Avalon, 1.75 oz. (14043)
    HerbsPro: CoQ10 Wrinkle Defense Night Creme, Avalon Organics, 1.75 oz. (67354)
    HerbsPro: CoQ10 Antioxidant Cream, Now Foods, 2 fl. oz. (71714)
    HerbsPro: CoQ10 Firming Lotion, Avalon Organics, 8 fl. oz. (14041)
    HerbsPro: CoQ10 Perfecting Facial Toner, Avalon Organics, 8 fl. oz. (34778)
    HerbsPro: CoQ10 Facial Cleansing Creme, Avalon Organics, 8.5 oz. (34777)
    HerbsPro: CoQ10 Facial Cleansing Gel, Avalon Organics, 8.5 oz. (67355)


    KALYX PRODUCTS

    Kalyx: Super CoQ10, TwinLab, 50 mg, 60 Caps: K
    Kalyx: Coenzyme Q-10, Natrol, 50 mg, 60 Caps: K
    Kalyx: CoEnzyme Q-10, Natrol, 200 mg, 45 softgels: K


    These merchants have hundreds more Coenzyme Q-10 (CoQ10) products available not listed here. This is only a small selection of products. If you do not see a brand, form or dosage here suitable for your purposes, click on one of the products above and do a search for a specific product.

  • CoEnzyme Q-10 (CoQ10) Supplement Information
  • CoEnzyme Q-10 Antioxidant Information






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    HELPFUL RELATED MOONDRAGON NUTRITION BASICS LINKS

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