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Tyrosine was first isolated from casein in 1849 and is abundant in insulin as well as the enzyme papain and can be synthesized from the amino acid phenylalanine in the body.
Tyrosine is a precursor of the neurotransmitters norepinephrine and dopamine, which regulate mood, among other things. Tyrosine acts as a mood elevator; a lack of adequate amounts of tyrosine leads to a deficiency of norepinephrine in the brain, which in turn can result in depression. It suppresses the appetite and helps to reduce body fat. It aids in the production of melanin (the pigment responsible for skin and hair color) and in the functions of the adrenal, thyroid, and pituitary glands. It is also involved in the metabolism of the amino acid phenylalanine.
It is used for stress reduction and may be beneficial in narcolepsy, fatigue, anxiety, depression, allergies, headaches as well as drug withdrawal. In a study, using soldiers, tyrosine proved effective in alleviating stress and keeping them more alert.
TYROSINE DEFICIENCY
Tyrosine is a precursor amino acid that attaches to iodine atoms to form active thyroid hormones (thyroxin). Not surprisingly, therefore, a defect in this and low plasma levels of tyrosine have been associated with hypothyroidism and an enlargement of the thyroid gland (goiter), severe growth failure, and retardation of central nervous system development.
Symptoms of tyrosine deficiency can also include low blood pressure, low body temperature (such as cold hands and feet), and "restless leg syndrome."
Tyrosine, a parent amino acid for skin, hair, and eye pigments and is involved in syndromes, known generally as oculocutaneous albinism, that are characterized by the failure to form melanin pigments, resulting in partial or complete albinism.
Supplemental L-tyrosine has been used for stress reduction, and research suggests it may be helpful against chronic fatigue and narcolepsy. It has been used to help individuals suffering from anxiety, depression, allergies, and headaches, as well as persons undergoing withdrawal from drugs. It may also help people with Parkinson's disease.
Tyrosine and tryptophan have with been used with some success in the treatment of cocaine abuse and in another study it was combined with the antidepressant Imipramine to treat chronic cocaine abuse where it was reported that the combination blocked the cocaine high and prevented the severe depression that accompanies withdrawal.
SOURCES
Natural sources of tyrosine include almonds, avocados, bananas, dairy products, eggs, lima beans, meat, pumpkin seeds, and sesame seeds.
If taking a tyrosine supplement it is best to take it at bedtime, or with a high carbohydrate meal to prevent competition of absorption with other amino acids. Folic acid, copper and vitamin B-6 is a good combination to have with this nutrient to maximize absorption and effectiveness.
Persons taking monoamine oxidase (MAO) inhibitors, commonly prescribed for depression, must strictly limit their intake of foods containing tyrosine and should not take any supplements containing L-tyrosine, as it may lead to a sudden and dangerous rise in blood pressure. Anyone who takes prescription medication for depression should discuss necessary restrictions with his or her health care provider.
MOLECULAR DESCRIPTION
Tyrosine is metabolically synthesized from phenylalanine to become the para-hydroxy derivative of that important amino acid. This hydroxylated amino acid participates in the synthesis of many important biochemicals including the thyroid hormones, the melanin biological pigments, and the catecholamines, an important class of biological regulators. Tyrosine is incorporated into proteins and enzymes at the molar rate of 3.5 percent with respect to the other amino acids.
DOSAGE
The dosage listed is the Recommended Daily Allowance (RDA), but be aware that this dosage is the minimum that you require per day, to ward off serious deficiency of this particular nutrient. In the therapeutic use of this nutrient, the dosage is usually increased considerably, but the toxicity level must be kept in mind.
Dosage levels are not confirmed but some experiments have been performed with people taking up to 5 - 7 grams per day, with no confirmed toxic levels, but people taking MAO inhibitors, who suffer from high blood pressure and have problems with skin cancer should not take supplementation of L-tyrosine, and should aim to limit their intake of food sources high in this nutrient.
TYROSINE SUPPLEMENTS & PRODUCTS
L-Tyrosine High Potency, NOW Foods, 750 mg, 90 Caps
L-Tyrosine is a non-essential amino acid that plays an important role in the production of the neurotransmitters dopamine and norepinephrine. In addition, because L-Tyrosine is necessary for the synthesis of thyroid hormone and epinephrine (adrenaline), L-Tyrosine supports healthy glandular function and stress response.
L-Tyrosine, Pharmaceutical Grade, Free Form, NOW Foods, 500 mg, 120 Caps
L-Tyrosine is used to treat insomnia, improve muscle tone, improve skin and hair pigment and depression and anxiety. L-Tyrosine should not to be used while taking prescription antidepressants or MAO inhibitors.
Herbal Remedies: Tyrosine / L-Tyrosine Supplements & Products
Herbal Remedies: Tyrosine / L-Tyrosine Information
MoonDragon's Health Information: Nutrition Basics - Amino Acids Index
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