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Nutrition Basics

Amino Acids

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  • Methionine Description
  • Methionine Uses, Health Benefits & Scientific Evidence
  • Methionine Dosage Information
  • Methionine Safety, Cautions & Interactions
  • Methionine Supplement Products



    Methionine is an essential sulfur amino acid. It is a part of the formation of numerous important compounds in your body. That formation is called "methylation." "Methylation" deficiency has been implicated in depression. This amino acid aids in your bodyís detoxification processes. Sunflower seeds are a great source of Methionine. Soy, on the other hand is deficient in Methionine. Diets deficient in this amino acid may result in a destructive breakdown and metabolism of protein. Methionine is critical in regulating the availability of folic acid, which is important especially during pregnancy.

  • Also see Nutrition Basics: SAM-e (S-Adenosyl-L-Methionine) Information.


    Methionine is a sulfur containing essential amino acid and was first isolated in 1922 from casein and belongs to a group of compounds called lipotropics - the others in this group include choline, inositol, and betaine. It is important in the process of methylation where methyl is added to compounds as well as being a precursor to the amino acids Cystine and Cysteine.

    Methionine is used to treat depression, alcoholism, liver disease, and reduce allergies and asthma. It has been used to reduce the toxic effects of radiation. This amino acid improves healing from surgery and other wounds. Some studies suggest that Methionine may reduce withdrawal symptoms and depression from heroin, barbiturates, or amphetamines. It can also be used as an adjunct to L-dopa treatment for Parkinsonís disease.

    Methionine is an essential amino acid that assists in the breakdown of fats, thus helping to prevent a buildup of fat in the liver, is often included in liver-detoxifying products called lipotropic combinations. These formulations are believed to accelerate the flow of bile and cell-damaging toxins away from the liver. It also helps prevent buildup of fat in the arteries that might obstruct blood flow to the brain, heart, and kidneys.

    The synthesis of the amino acids Cysteine and Taurine may depend on the availability of Methionine. This amino acid helps the digestive system; helps to detoxify harmful agents such as lead and other heavy metals; helps diminish muscle weakness, prevent brittle hair, and protect against radiation; and is beneficial for people with osteoporosis or chemical allergies. It is useful also in the treatment of rheumatic fever and toxemia of pregnancy.

    Methionine is a powerful antioxidant. It is a good source of sulfur, which inactivates free radicals. Sulfur, a mineral, helps to maintain healthy skin tone, well-conditioned hair, and strong nails. It is also good for people with Gilbert's syndrome, an anomaly of liver function, and is required for the synthesis of nucleic acids, collagen, and proteins found in every cell of the body.

    Methionine in lipotropic combinations has been proposed for treating endometriosis, a condition in which patches of endometrial tissue from the uterine lining grow outside the uterus. The nutrient is believed to help by expediting the removal of excess estrogen from the liver. The bleeding, cramps, pain, and other complications of this common ailment may subside as a result. More research is needed, however.

    It is beneficial for women who take oral contraceptives because it promotes the excretion of estrogen. It reduces the level of Histamine in the body, which can be useful for people with schizophrenia, whose Histamine levels are typically higher than normal. Some studies have also indicated that Methionine might improve memory recall.

    As levels of toxic substances in the body increase, the need for Methionine increases. The body can convert Methionine into the amino acid Cysteine, a precursor of Glutathione. Methionine thus protects Glutathione; it helps prevent Glutathione depletion if the body is overlooked with toxins. Since Glutathione is a key neutralizer of toxins in the liver, this protects the liver from the damaging effects of toxic compounds.


    An essential amino acid, Methionine is not synthesized in the body, and so must be obtained from food sources or from dietary supplements. Good food sources of Methionine include beans, eggs, fish, garlic, lentils, meat (chicken & beef), onions, soybeans, seeds, cheddar cheese and yogurt. Because the body uses Methionine to derive a brain food called Choline, it is wise to supplement the diet with Choline or Lecithin (which is high in Choline) to ensure that the supply of Methionine is not depleted. It is best to balance Methionine with Choline and Inositol.

    microscopic methionine


    Methionine is an important amino acid that helps to initiate translation of messenger RNA by being the first amino acid incorporated into the N-terminal position of all proteins. This sulfur-containing amino acid is also the source of sulfur for cysteine in animals and man. In that regard, methionine is considered an essential amino acid whereas cysteine is not, so cysteine is non-essential only as long as the diet contains adequate amounts of methionine. The terminal methyl group of the methionine side chain often participates in biochemical methyl transfer reactions making methionine a member of the "methyl donor" class of biochemicals. On a molar basis, methionine is incorporated into proteins and enzymes at the rate of 1.7-percent, but this is partially due to post-translational protein-modifying events that often occur where Methionine and several other N-terminal amino acids are removed from the protein.



    For optimal health, 50 mg of L-methionine is recommended per day.

    Amino acid supplements prefaced by the letter L, such as L-methionine, are more similar to the amino acids in the body than those that start with the letter D, with the exception of D-L phenylalanine, which treats chronic pain. The standard Methionine dose is 1 capsule 1 to 3 times daily with or without food. At the same time you should be using a good multivitamin & mineral supplement.


    Severe Methioninedeficiency may manifest in dementia, while lesser deficiencies may be known by symptoms like fatty liver, slow growth, weakness, edema and skin lesions.

    Supplements may be required for people with liver problems, pancreatitis, HIV/AIDS as well as Parkinson's disease may consider obtaining more Methionine, after consultation with their health professional, and older people may also benefit from a slightly higher intake of this nutrient.

    Women on birth control pills could also look at this nutrient, since it promotes the excretion of estrogen. People suffering from schizophrenia could investigate taking extra Methionine since it reduces the level of Histidine in the body, a level normally higher in people suffering from schizophrenia.


    It has been suggested that a high intake of Methionine, in the presence of B-vitamin deficiencies, may increase the risk for arteriosclerosis (hardening of the arteries) by increasing blood levels of cholesterol and a compound called homocysteine; and that excessive Methionine intake, with an inadequate intake of Folic Acid, Vitamin B-6 and Vitamin B-12, may increase the rate of conversion of Methionine to homocysteine - both these theories have not been proven in humans.

    Those who are experiencing low serum levels of essential blood proteins, apathy, loss of pigmentation in hair, edema, lethargy, liver damage, muscle loss, fat loss, skin lesions, weakness, or marked slowed growth in children could be suffering from an Methionine deficiency. There are no known cautions associated with taking Methionine. There are no known drug or nutrient interactions associated with methionine.

    Avoid taking more than the commonly recommended amount of Methionine. This is particularly important if your diet is low in Folic Acid, Vitamin B-6 or Vitamin B-12, because this could increase the conversion of Methionine to homocysteine. Homocysteine is a potentially harmful blood fat that has been linked to atherosclerosis (hardening of the arteries).

    If you have any serious illness or are pregnant, only take an amino acid, such as Methionine, after consulting your health care provider.

    To be safe, never take Methionine, or any single amino acid for that matter, for longer than three months unless you are under the direction of a health care provider familiar with its use.


  • Amino Acid Complex Supplement Products

  • Methionine Amino Acid Supplement Products
  • SAM-e (S-Adenosyl-L-Methionine) Products


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    HerbsPro: L-Methionine, Solgar, 500 mg, 30 VCaps (36576)
    HerbsPro: L-Methionine, Bluebonnet Nutrition, 500 mg, 30 VCaps (100418)
    HerbsPro: L-Methionine, TwinLab, 500 mg, 30 Caps (19680)
    HerbsPro: L-Methionine, Solgar, 500 mg, 60 VCaps (36577)
    HerbsPro: L-Methionine With Vitamin B-6, Country Life, 500 mg, 60 Tabs (37277)
    HerbsPro: L-Methionine, Solgar, 500 mg, 90 VCaps (36578)
    HerbsPro: L-Methionine, Nutricology, 500 mg, 100 Caps (46040)
    HerbsPro: L-Methionine, Now Foods, 500 mg, 100 Caps (68385)
    HerbsPro: L-Methionine Powder, Source Naturals, 100 gm, 3.53 oz. (7051)


    Amazon: Methionine Amino Acid Supplement Products
    Amazon: S-Adenosyl-Methionine (SAM-e) Supplement Products
    Amazon: Sam-E Supplement Products

  • Nutrition Basics: Methionine Amino Acid Supplement Information


    SAMe is a stable, bioavailable form of S-Adenosyl-L-Methionine. Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. It is important to the joints because of its critical role in cartilage formation. Studies also show that SAMe helps support a positive outlook. It is able to cross the blood-brain barrier where it affects the synthesis and activation of various proteins, such as neurotransmitters. SAMe is known as a "methyl donor." This means that it works by giving up a piece of itself (a methyl group consisting of one carbon and three hydrogen atoms) to other molecules. Methylation plays a part in many critical cellular functions. SAMe is present in every living cell in the body. However, levels of SAMe tend to decline with age. Helps to reduce stress and depression. Gives a sense of well being. Do not use if you have manic-depressive disorder or take prescription antidepressants.


    HerbsPro: SAM-e, Woodland Publishing, 30 Page Booklet, (90200)
    HerbsPro: SAM-e, Now Foods, 100 mg, 30 Tabs (68690)
    HerbsPro: SAM-e, Now Foods, 100 mg, 60 Tabs (68691)
    HerbsPro: SAM-e, Jarrow Formulas, 200 mg, 20 Tab Blister Pack (1111)
    HerbsPro: SAM-e (S-Adenosyl-L-Methionine), Natrol, 200 mg, 20 Tabs (7357)
    HerbsPro: SAM-e (S-Adenosyl-L-Methionine), Natrol, 200 mg, 20 Tabs (16841)
    HerbsPro: SAM-e, Natural Factors, 200 mg, 30 Tabs (84355)
    HerbsPro: SAM-e, Now Foods, 200 mg, 30 Tabs (68693)
    HerbsPro: SAM-e, Now Foods, 200 mg, 60 Tabs (68691)
    HerbsPro: SAM-e, Doctors Best, 200 mg, 60 Tabs (79249)
    HerbsPro: SAM-e, Jarrow Formulas, 200 mg, 60 Tabs (3304)
    HerbsPro: SAM-e (S-Adenosyl-L-Methionine), Source Naturals, 200 mg, 60 Tabs (7358)
    HerbsPro: SAM-e, Joint Health, Jarrow Formula, 200 mg, 60 Caps (73958)
    HerbsPro: SAM-e, Foodscience of Vermont, 200 mg, 60 Caps (15167)
    HerbsPro: SAM-e, Maximum Strength, Life Time Nutritional Specialties, 400 mg, 30 Tabs (98905)
    HerbsPro: SAM-e, Jarrow Formulas, 400 mg, 30 Tabs (35985)
    HerbsPro: SAM-e, Now Foods, 400 mg, 30 Tabs (68694)
    HerbsPro: SAM-e, Now Foods, 400 mg, 60 Tabs (68695)


    Amazon: Methionine Amino Acid Supplement Products
    Amazon: S-Adenosyl-Methionine Supplement Products
    Amazon: Sam-E Supplement Products

  • Nutrition Basics: SAM-e (S-Adenosyl-Methionine) Supplement Information



    HerbsPro: Amino-9 Essentials Powder, Now Foods, 330 Grams
    Complete Free Form blend of all 9 essential amino acids. Dietary supplements helpful in sports. GMP quality assured.
    HerbsPro: Amino Balance Powder, Free Form Amino Acid Complex, Anabol Naturals
    HerbsPro: Amino Balance Powder, Free Form Amino Acid Complex, Anabol Naturals, 500 grams
    HerbsPro: Amino Balance, Free Form Amino Acid Complex, Anabol Naturals, 500 mg, 120 Caps
    HerbsPro: Amino Balance, Free Form Amino Acid Complex, Anabol Naturals, 500 mg, 240 Caps
    HerbsPro: Amino Balance, Free Form Amino Acid Complex, Anabol Naturals, 500 mg, 500 Caps
    For tissue repair, reduced soreness and accelerated recovery, as well as a wealth of non-training benefits, this blend of 23 pure crystalline 100% pharmaceutical grade free-form amino acids is unmatched.
    HerbsPro: Amino Max 21, FoodScience of Vermont, 90 Caps
    A high quality, hypoallergenic amino acid formulation. Amino Max 21 is a scientifically formulated combination of 21 crystalline, free-form amino acids in the natural L-configuration. Because free-form amino acids are readily bioavailable and require no digestion by the body, they can be absorbed efficiently into the bloodstream and accompanying tissues where they are used for cellular regeneration.
    HerbsPro: Essential Amino Acid Complex, Solgar, Free Form, 600 mg, 90 VCaps (36384)
    HerbsPro: Amino Complete, Balanced Blend Complex, Now Foods, 120 Caps
    HerbsPro: Max-Amino With Vitamin B-6, Blend of 18 Amino Acids, Country Life, 180 Caps
    An easily absorbed blend of 18 amino acids yielding high biological activity. An ideal formula for athletes, and when protein demands may not be fully satisfied. B-6 aids in the utilization of amino acids. An easily absorbed Amino Acid Supplement.
    HerbsPro: Amino Acid Complete, Balanced Blend Complex, Now Foods, 360 Caps
    HerbsPro: Cher-Amino Liquid Protein, TwinLab, 16 fl. oz. (19499)
    Cher Amino Protein is a concentrated and peptide bonded free amino acid supplement contains all essential amino acid derived from natural enzyme hydrolysis of collagen protein and whey protein that help relieve muscle breakdown.
    HerbsPro: Cher-Amino Liquid Protein, TwinLab, 32 fl. oz. (19498)
    Cher Amino Protein is a concentrated and peptide bonded free amino acid supplement contains all essential amino acid derived from natural enzyme hydrolysis of collagen protein and whey protein that helps to relieve muscle breakdown. The protein in this product is a predigested collagen and whey (lactalbumin) protein and is therefore utilized 100%. Contains all the essential amino acids derived by enzymatically hydrolyzing the animal protein collagen and whey protein (lactalbumin). The amino acids in this product are naturally present in the protein. They are not added or manufactured. 15 grams per ounce. New improved formula. Predigested collagen. Enriched with predigested whey protein, a superior source of high quality amino acids.


    Amazon: Amino Acid Complex Complete Supplement Products

  • Nutrition Basics: Amino Acid Complex Supplement Information

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  • MoonDragon's Nutrition Basics Index
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