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MoonDragon's Health & Wellness
Nutrition Basics

Amino Acids

For Informational Use Only
For more detailed information contact your health care provider
about options that may be available for your specific situation.

  • Lysine Description
  • Lysine Uses, Health Benefits & Scientific Evidence
  • Lysine Dosage Information
  • Lysine Safety, Cautions & Interactions
  • Lysine Supplement Products



    Lysine was first isolated in 1889 from casein. Lysine is one of numerous amino acids that the body needs for growth and tissue repair. It is classified as one of the nine "essential" amino acids because you need to get it from outside sources such as foods and supplements since the body cannot make it on is own. Like all amino acids, lysine is a necessary building block for all protein. Lysine is an essential amino acid that is required for growth and bone development in children as it assists in calcium absorption and it maintains the correct nitrogen balance in the body, and maintains lean body mass in adults. Lysine is also needed to produce disease-fighting antibodies, hormones, enzymes, collagen formation, and is vital to the repair of tissue. Lysine can be found in numerous foods, but the richest sources include red meats, fish, and dairy products (milk, eggs, cheese). Beans, peas and lentils are also a good source.

    There might be use in lysine to help maintain healthy blood vessels. Because it helps to build muscle protein, it is good for those recovering from surgery and sports injuries. It also lowers high serum triglyceride levels.

    Another very useful ability of this amino acid is its capacity for fighting cold sores and herpes viruses. Taking supplemental Lysine, together with Vitamin C with Bioflavonoids, can effectively fight and/or prevent herpes outbreaks, especially if foods containing the amino acid Arginine are avoided.


    Lysine is an essential amino acid, as so cannot be manufactured in the body. It is therefore vital that adequate amounts be included in the diet. Food sources of lysine are numerous, but the richest sources include cheese, eggs, fish, lima beans, milk, potatoes, red meat, soy products, and yeast. Vegetables are generally a poor source of Lysine, with the exception of legumes (beans, peas, lentils).

    microscopic lysine


    Lysine is an essential amino acid that has a net positive charge at physiological pH values making it one of the three basic (with respect to charge) amino acids. This polar amino acid is commonly found on the surfaces of proteins and enzymes, and sometimes appears in the active site. Sources of lysine include meats, fish, poultry, and dairy products. Lysine is incorporated into proteins at the rate of 7 percent on a molar basis compared to the other amino acids.


    Due to its ability to help repair tissue, Lysine is often given to patients recovering from injuries and recovery after operations. It is possible that Lysine may help maintain healthy blood vessels. Health care practitioners prescribe Lysine to people with cold sores, shingles, and genital herpes. Current scientific studies are being conducted as to Lysine's effectiveness in lowering cholesterol and improving athletic performance.

    Researchers are exploring the value of lysine supplementation and the consumption of Lysine-rich foods for lowering cholesterol, improving athletic performance, and enhancing recovery after surgery. Lysine may help prevent osteoporosis since lysine promotes the body's absorption of calcium. It slows the damage to the eyes caused by diabetes and may help prevent cataracts. It may help to boost the immune system and its antiviral properties may help treat chronic fatigue syndrome, hepatitis, and HIV, and burn patients. Older people could also require more Lysine, as one study found older men required more of this nutrient than younger men.

    Some nutritionally oriented healthcare providers and dentists recommend taking Lysine during an outbreak of canker sores to speed healing. The exact cause of these tiny but quite painful mouth ulcers is unclear, but most research indicates that a virus is responsible. However, there have been almost no clinical trials using lysine as a remedy for canker sores.

    The most promising application of Lysine is its use in managing and preventing painful and unsightly herpes sores caused by the herpes simplex virus (HSV).


    Lysine may help to prevent and relieve cold sores (herpes). Exciting research over the past several decades suggests that lysine may be helpful in controlling herpes simplex-related infections. There are two types of this virus: type 1, which typically causes cold sores or fever blisters around the mouth, and type 2, which tends to cause genital sores. However, both forms can cause eruptions around the mouth or on the genitals. Once infected with the virus, you have it permanently. It may lie dormant, but it does not go away. Outbreaks are usually painful and unsightly, as well as contagious.

    A few years ago, researchers discovered that in order to grow (replicate), the herpes virus needs Arginine, another common amino acid. (Foods high in Arginine include chocolate, peanuts, almonds, seeds, cereal grains, gelatin, and raisins.) Lysine competes with arginine for absorption and entry into tissue cells. And when Lysine is present, it inhibits the growth of HSV by knocking out arginine.

    This makes a diet high in Lysine and low in arginine a useful tool in managing HSV infections. In a recent study, participants consumed large amounts of lysine (about 1 gram three times each day) while restricting food sources of arginine. A significant number of participants (74%) noticed an improvement in their HSV infections and a decrease in the number of outbreaks.

    Lysine supplements (as opposed to foods high in this nutrient) can also play an important role in staving off and reducing the severity of herpes-related cold sores. Results of a six-month trial involving more than 50 people indicate that lysine is far more effective than a placebo in preventing cold sores. Participants given a placebo had more than twice as many such infections as those taking lysine. Moreover, the herpes sores that did develop in the lysine group tended to be milder, and to heal faster, than the outbreaks in the placebo group.

    Lysine supplements may even prevent HSV outbreaks in chronic sufferers.

    Speed healing of shingles lesions. Painful shingles blisters are caused by a reactivation of varicella-zoster virus, an infection that started out as an attack of chickenpox. Herpes zoster is closely related to herpes simplex, however, and Lysine appears to have a similar role to play in treating an eruption of shingles. Keep in mind, however, that most nutritionally oriented healthcare providers will combine Lysine therapy with conventional antiviral medications such as acyclovir or valacyclovir.

    MoonDragon's Health & Wellness: Herpes Virus Infection
    MoonDragon's Womens Health Information: Genital Herpes
    MoonDragon's Health & Wellness: Cold Sores (Fever Blisters)
    MoonDragon's Health & Wellness: Canker Sores
    MoonDragon's Health & Wellness: Shingles



    Lysine supplements are available in tablet, powder, liquid and capsule forms. Amino acid supplements prefaced by the letter L, such as L-Lysine, are more similar to the amino acids in the body than those that start with the letter D, with the exception of D-L phenylalanine, which treats chronic pain. Most people do not need to take Lysine as a dietary supplement; however, health care providers often suggest that people with recurrent herpes simplex infections take 1,000 to 3,000 mg of Lysine per day. For treating a severe initial outbreak of genital herpes or shingles, consult with your health care provider before using Lysine for the treatment of your condition. Do not drink milk at the same time you are taking Lysine.

    It is estimated that the daily requirement for an adult is approximately 12 mg per kilogram (2.2 lb) of body weight, which would translate to about 840 mg for a 70 kg male (approximately 150 lbs). While many people satisfy their need for Lysine through dietary sources, supplements are now popular for treating and preventing specific ailments as well.

    • Infant 3 to 6 months: 97 mg per kg of body weight
    • Child 10 to 12 years: 44 mg per kg of body weight
    • Adults: 12 mg per kg of body weight


  • Of all the amino acids, Lysine is the most sensitive to the effects of food processing, such as dry heat. The amount of protein available in legumes and other sources of lysine can be significantly reduced if they have been toasted or roasted.

  • Common foods high in Lysine include nonfat milk (8 fluid ounces, or 245 grams, contains about 660 mg of lysine) and whole-wheat bread (one slice of wheat bread, or 28 grams, provides 85 mg of lysine).

  • For Canker Sores: Take 1,000 mg L-Lysine three times a day with meals while a canker sore is present. Reduce the dose to 500 mg three times a day for one week following healing.

    For Cold Sores: Take 1,000 mg L-Lysine three times a day with meals for flare-ups. If you are subject to recurrent outbreaks of cold sores, continue on a maintenance dosage of 1,000 mg day.

    For Shingles: Take 1,000 mg L-Lysine three times a day with meals during flare-ups. Reduce the dose to 500 mg three times a day for one week after healing.


    Although a deficiency of Lysine is rare, since it is found in so many protein foods, the symptoms may include anemia, bloodshot eyes, enzyme disorders, hair loss, an inability to concentrate, irritability, lack of energy, poor appetite, reproductive disorders, retarded growth, and weight loss.

    Lysine supplements are best used by individuals suffering from a herpes outbreak or by people on vegan or vegetarian diets and low-fat dieters. People using grains as their only source of protein are often deficient in this nutrient. Post-menopausal women can takeLysine to encourage absorption of calcium by the body.


    Vegetarians whose diets contain large amounts of grains and only minimal amounts of beans could become deficient in Lysine, people recovering from burns, and athletes involved in frequent vigorous exercise have increased need for essential amino acids.

    Lysine is safe when taken in the recommended doses; however, in large doses (10 to 30 grams a day), this amino acid increases the toxicity of aminoglycoside antibiotics, such as gentamicin, neomycin, and streptomycin. Side effects such as abdominal cramping and diarrhea are rare, but can happen when taking larger doses. Do not take this supplement if you have diabetes or severe liver or kidney disease.

    Toxicity has not been determined but animals fed high amounts of lysine, have shown a tendency to gallstones as well as elevated cholesterol - but these tendencies have not been proven in humans.

    Side effects are rare with lysine supplements, although a few cases of abdominal cramps and diarrhea have been reported with very high doses (more than 10 grams a day). However, these are not consistent symptoms.


    Supplemental combinations of amino acids are not recommended to build muscle. Excessive build-up of protein in the body can cause kidney and liver problems. L-Lysine is best taken as a single supplement and not in combination with other amino acids. Such combinations are touted as nutritional supplements that build more muscle and are often used by athletes and bodybuilders. However, too much protein strains the functions of the liver and kidneys and can cause other health problems. The single supplement should be taken on an empty stomach because larger amounts of the amino acid can build up in the blood and brain, enhancing its health benefits.

    For a severe initial outbreak of genital herpes or shingles, see your healthcare provider to confirm that you have the condition and you may be prescribed antiviral drugs such as acyclovir.

    Do not drink milk at the same time you take Lysine.

    Pregnant or breastfeeding mothers, as well as patients with liver or kidney problems, must first consult a health professional or midwife before taking Lysine supplements.


  • Amino Acid Complex Supplement Products

  • Lysine Amino Acid Supplement Products


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    HerbsPro: L-Lysine Powder, Source Naturals, 100 Grams (3.53 oz.) (7050)
    HerbsPro: L-Lysine, Natures Life, Unflavored, 200 Grams (105986)
    HerbsPro: L-Lysine Powder, Now Foods, 1 lb. (68436)
    HerbsPro: L-Lysine, Thompson Nutritional Products, 500 mg, 60 Tabs (35639)
    HerbsPro: L-Lysine, FoodScience of Vermont, 500 mg, 100 Tabs (74927)
    HerbsPro: L-Lysine, Now Foods, 500 mg, 100 Tabs (68432)
    HerbsPro: L-Lysine, Now Foods, 500 mg, 100 Caps (68434)
    HerbsPro: L-Lysine, TwinLab, 500 mg, 100 Caps (19679)
    HerbsPro: L-Lysine, Free Form Amino Acid With Vitamin B-6, Country Life, 500 mg, 100 Tabs (45818)
    HerbsPro: L-Lysine, Essential Amino Acid For Protein Metabolism, Jarrow Formulas, 500 mg, 100 Caps (1169)
    HerbsPro: L-Lysine, Sundown Naturals, 500 mg, 100 Tabs (102797)
    HerbsPro: L-Lysine, Anabol Naturals, 500 mg, 100 Caps (104554)
    HerbsPro: L-Lysine, Natures Bounty, 500 mg, 100 Tabs (97369)
    HerbsPro: L-Lysine, Solgar, 500 mg, 250 VCaps (36574)
    HerbsPro: L-Lysine, Natures Life, 500 mg, 250 Caps (90168)
    HerbsPro: L-Lysine, Now Foods, 500 mg, 250 Tabs (68433)
    HerbsPro: L-Lysine, Now Foods, 500 mg, 250 Caps (68435)
    HerbsPro: L-Lysine, Anabol Naturals, 500 mg, 500 Caps (104555)
    HerbsPro: L-Lysine, Life Extension, 620 mg, 100 Caps (94383)
    HerbsPro: L-Lysine, Natures Bounty, 1000 mg, 60 Tabs (100069)
    HerbsPro: L-Lysine, Now Foods, 1000 mg, 100 Tabs (68384)
    HerbsPro: L-Lysine, BlueBonnet Nutrition, 1000 mg, 100 Caplets (100417)
    HerbsPro: L-Lysine, Solgar, 1000 mg, 250 Tabs (36571)
    HerbsPro: L-Lysine, Natures Life, 1000 mg, 250 Tabs (90345)
    HerbsPro: L-Lysine With B-6, Country Life, 1000 mg, 250 Tabs (37272)
    HerbsPro: Super Lysine Plus Liquid Extract, Quantum Research, 2 fl. oz. (18569)
    Super Lysine Plus Liquid is a formulation designed to enhance immune function, speed recovery and relieve future cold sore and herpes breakouts. Super Lysine Plus Liquid Extract Immune System with Echinacea and Shiitake Extracts. As a tea or aid to the diet. Use 30 drops in hot or cold water 3 to 6 times a day.
    HerbsPro: Lysine Lip Balm, Medicated, Morgans, 0.17 oz. (96313)
    HerbsPro: Lysine Lip Clear Plus Cold Sore Ointment, Quantum Research, 0.23 oz. (18556)
    HerbsPro: Super Lysine Plus Cream, Quantum Research, 0.75 oz. (18567)
    HerbsPro: L-Lysine Cat Chews, Pet Naturals of Vermont, 250 mg, 60 Chews (94913)


    LEF: L-Lysine, Life Extension, 620 mg, 100 vegetarian capsules


    Kalyx: Super Lysine Plus LipClear Coldstick, SPF 21, Quantum, 5 Grams: C
    Kalyx: Super Lysine Plus Coldstick, SPF 21, Quantum, 5 Grams: K
    Kalyx: Super Lysine Plus Ointment, Cold Sore Treatment, Quantum, 7 Grams: C
    Kalyx: Super Lysine Plus Cream, Quantum, 0.25 oz: K
    All Natural Cold Sore Treatment. America's #1 Natural Formula. Clinically Proven. Clinically Shown to Cut Healing Time in Half. Goes on Clear. Immediate Relief. Lysine with 14 Healing Herbs and Vitamins. Relieves Tingling, Blistering and Itching and Pain Associated with Cold Sores. Soothes, Doesn't Burn.
    Kalyx: L-Lysine, Thompson Amino Acids, 500 mg, 60 Tabs: K
    Kalyx: Super Lysine Plus, Quantum, 90 Tabs: K
    Kalyx: Super Lysine Plus, Quantum, 90 Tabs: C
    Super Lysine Plus Immune system with Vitamin C, Echinacea, Goldenseal, Licorice, Propolis, odorless garlic. Super Lysine Plus tablets is a formulation designed to enhance immune function, speed recovery and prevent future cold sore and herpes breakouts. Dietary Supplement with 5 herbal boosters.
    Kalyx: Super Immune Plus Power Formula (With Lysine), Quantum, 90 Caps: C
    Quantum Super Lysine Plus Immune System with 5 Herbal Boosters combine taking the tablets with the use of Super Lysine Plus Cream for the most powerful effect - especially when dealing with cold sores. Users report that they take the tablets daily and increase dosage whenever symptoms are about to appear in order to prevent outbreaks. This popular system strength formula combines L-Lysine, Vitamins A and C and Garlic with herbal boosters including Echinacea, Propolis, Licorice and Goldenseal.
    Kalyx: L-Lysine, Nutricology, 500 mg, 100 VCaps: N
    L-lysine is an essential amino acid, important for the absorption of calcium, the formation of collagen (contained in cartilage, connective tissue, skin, hair and bone), and the production of bone tissue. Free form amino acid, high purity, well tolerated. Suggested Use: As a dietary supplement, 1 or 2 capsules one to three times daily between meals, or as directed by a health practitioner.
    Kalyx: Super Lysine Plus, Quantum, 180 Tabs: K
    Kalyx: Super Lysine Plus, Quantum, 180 Tabs: C
    Kalyx: Super Lysine Plus Liquid Extract, Quantum, 2 fl oz: K
    Kalyx: L-Lysine HCL, USP Grade, Kalyx Bulk Products, 25 Kg (55 lbs): NB
    Kalyx: L-Lysine HCL, USP Grade, Kalyx Bulk Products, 25 Kg (55 lbs): GF


    Amazon: Lysine Amino Acid Supplement Products

    VIR-L-Lysine Immune System Booster, With Bee Pollen, Global Health Services Inc, 1000 mg, 90 Caps
    Dietary supplement contains the amino acid L-Lysine and Bee Pollen to help boost the body's immune system. Vir-L-Lysine is a scientifically designed supplement. This preparation has been compounded in a specially designed base of Amino Acids and formulating aids for maximum stability. L-Lysine is a natural constituent in food. As a food supplement or an antiviral agent, take three capsules on an empty stomach for 10 to 30 consecutive days at the first sign of viral reakout. Use as often as needed.

  • Nutrition Basics: Lysine Amino Acid Supplement Products



    HerbsPro: Amino-9 Essentials Powder, Now Foods, 330 Grams
    Complete Free Form blend of all 9 essential amino acids. Dietary supplements helpful in sports. GMP quality assured.
    HerbsPro: Amino Balance Powder, Free Form Amino Acid Complex, Anabol Naturals
    HerbsPro: Amino Balance Powder, Free Form Amino Acid Complex, Anabol Naturals, 500 grams
    HerbsPro: Amino Balance, Free Form Amino Acid Complex, Anabol Naturals, 500 mg, 120 Caps
    HerbsPro: Amino Balance, Free Form Amino Acid Complex, Anabol Naturals, 500 mg, 240 Caps
    HerbsPro: Amino Balance, Free Form Amino Acid Complex, Anabol Naturals, 500 mg, 500 Caps
    For tissue repair, reduced soreness and accelerated recovery, as well as a wealth of non-training benefits, this blend of 23 pure crystalline 100% pharmaceutical grade free-form amino acids is unmatched.
    HerbsPro: Amino Max 21, FoodScience of Vermont, 90 Caps
    A high quality, hypoallergenic amino acid formulation. Amino Max 21 is a scientifically formulated combination of 21 crystalline, free-form amino acids in the natural L-configuration. Because free-form amino acids are readily bioavailable and require no digestion by the body, they can be absorbed efficiently into the bloodstream and accompanying tissues where they are used for cellular regeneration.
    HerbsPro: Essential Amino Acid Complex, Solgar, Free Form, 600 mg, 90 VCaps (36384)
    HerbsPro: Amino Complete, Balanced Blend Complex, Now Foods, 120 Caps
    HerbsPro: Max-Amino With Vitamin B-6, Blend of 18 Amino Acids, Country Life, 180 Caps
    An easily absorbed blend of 18 amino acids yielding high biological activity. An ideal formula for athletes, and when protein demands may not be fully satisfied. B-6 aids in the utilization of amino acids. An easily absorbed Amino Acid Supplement.
    HerbsPro: Amino Acid Complete, Balanced Blend Complex, Now Foods, 360 Caps
    HerbsPro: Cher-Amino Liquid Protein, TwinLab, 16 fl. oz. (19499)
    Cher Amino Protein is a concentrated and peptide bonded free amino acid supplement contains all essential amino acid derived from natural enzyme hydrolysis of collagen protein and whey protein that help relieve muscle breakdown.
    HerbsPro: Cher-Amino Liquid Protein, TwinLab, 32 fl. oz. (19498)
    Cher Amino Protein is a concentrated and peptide bonded free amino acid supplement contains all essential amino acid derived from natural enzyme hydrolysis of collagen protein and whey protein that helps to relieve muscle breakdown. The protein in this product is a predigested collagen and whey (lactalbumin) protein and is therefore utilized 100%. Contains all the essential amino acids derived by enzymatically hydrolyzing the animal protein collagen and whey protein (lactalbumin). The amino acids in this product are naturally present in the protein. They are not added or manufactured. 15 grams per ounce. New improved formula. Predigested collagen. Enriched with predigested whey protein, a superior source of high quality amino acids.


    Amazon: Amino Acid Complex Complete Supplement Products

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  • MoonDragon's Nutrition Basics Index
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