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MoonDragon's Health & Wellness
Nutrition Basics

Amino Acids
GLUTAMINE


For Informational Use Only
For more detailed information contact your health care provider
about options that may be available for your specific situation.





  • Glutamine Description
  • Glutamine Uses, Health Benefits & Scientific Evidence
  • Glutamine Dosage Information
  • Glutamine Safety, Cautions & Interactions
  • Glutamine Supplement Products




  • GLUTAMINE DESCRIPTION

    A NON-ESSENTIAL AMINO ACID

    Glutamine is a non-essential amino acid, meaning that the body can create is own supply if the diet is lacking in Glutamine-rich sources. Some people refer to it as a "smart-vitamin" - although it is in actual fact no vitamin at all. Glutamine helps maintain the proper acid / alkaline balance in the body. It is also the basis of the building blocks for the synthesis of RNA and DNA. Glutamine is known as brain fuel. Glutamine is converted into glutamic acid, and glutamic acid converts into Glutamine, which are both necessary for cerebral function. This amino acid also increases the amount of GABA which is important to brain function and mental activity. Glutamine is found in numerous plants and animals; however, it is easily destroyed through cooking. Raw Spinach and Parsley are excellent sources of Glutamine.

    microscopic glutamine


    MOLECULAR DESCRIPTION

    Glutamine is one of the twenty amino acids generally present in animal proteins. A monoamide of Glutamic Acid, the biochemical is also a component of many plants and was first isolated from beet juice in 1883. Glutamine was not isolated as a component from a protein, however, until 1932 and was first chemically produced the following year. The substance plays an important role in the cellular metabolism of animals and is the only amino acid with the ability to easily cross the barrier between blood and brain tissue. Combined, Glutamine and Glutamic Acid are responsible for the vast majority of the amino nitrogen located in the brain, and are of central importance in the regulation of bodily ammonia levels. Though it is readily synthesized naturally within the body, Glutamine is popularly sold as a nutritional supplement for athletes.





    GLUTAMINE USES, HEALTH BENEFITS & SCIENTIFIC EVIDENCE

    Glutamine helps build and maintain muscle; therefore, bodybuilders and dieters find this supplement useful, but more importantly, it prevents muscle-wasting that happens with prolonged bed rest or diseases such as cancer and AIDS.

    Glutamine supplementation can help treat arthritis, autoimmune disease, fibrosis, intestinal disorders, peptic ulcers, connective tissue disease, and tissue damage caused by radiation treatments.

    Due to its ability to enhance mental function, Glutamine is also beneficial in treating epilepsy, fatigue, impotence, depression, schizophrenia, and senility. It also decreases sugar cravings and the desire for alcohol.

    BRAIN FUNCTION

    Glutamine is the most abundant free amino acid found in the bloodstream and the muscles of the body. Because it can readily pass the blood-brain barrier, it is known as brain fuel. In the brain, Glutamine is converted into Glutamic Acid - which is essential for cerebral function - and vice versa. It also increases the amount of GABA (Gamma-Aminobutyric Acid), which is needed to sustain proper brain function and mental activity. Glutamine promotes mental ability, and may stimulate mental alertness and clear thinking. This use is still unproven.

    Glutamine assists in maintaining the proper acid / alkaline balance in the body, and is the basis of the building blocks for the synthesis of RNA and DNA.

    When an amino acid is broken down, nitrogen is released. The body needs nitrogen, but free nitrogen can form ammonia, which is especially toxic to brain tissues. The liver can convert nitrogen may attach itself to Glutamic Acid, while removing ammonia from the brain. This process forms Glutamine. Glutamine is unique among the amino acids in that each molecule contains not one nitrogen atom but two. Thus, its creation helps to clear ammonia from the tissues, especially brain tissue, and it can transfer nitrogen from one place to another.

    MUSCLE HEALTH & MAINTENANCE

    Glutamine is found and produced in large amounts in the muscles and is readily available when needed for the synthesis of skeletal muscle proteins and appears to play an important part in keeping them functioning normally. Because this amino acid helps to build and maintain muscle, supplemental Glutamine is useful for dieters and bodybuilders. It is also used by white blood cells and contributes to normal immune-system function. Individuals with muscle-wasting and immune-system related illnesses (such as cancer or AIDS) who may be incapable of manufacturing their own supply of Glutamine, may benefit from Glutamine supplements taken along with other amino acids. More importantly, it helps to prevent the kind of muscle-wasting that can accompany prolonged bed rest or diseases such as cancer and AIDS. This is because stress and injury (including surgical trauma) cause the muscles to release Glutamine into the bloodstream. In fact, during times of stress, as much as one-third of the Glutamine present in the muscles may be released. As a result, stress and/or illness can lead to the loss of skeletal muscle. If enough Glutamine is available, however, this can prevented.

    INFLAMMATORY THERAPY

    Supplemental L-Glutamine can be helpful in the treatment of arthritis, autoimmune diseases, fibrosis, intestinal disorders such as ulcerative colitis, peptic ulcers, connective tissue diseases such as polymyositis and scleroderma, epilepsy, fatigue, impotence, and tissue damage due to radiation treatment for cancer. Several studies have shown that Glutamine, when used as an oral rinse, can help to reduce cancer chemotherapy-induced mouth sores. Whether Glutamine taken orally can aid in preventing other complications of cancer treatment, including stomach irritation, is still being examined. In fact, some research indicates it may stimulate the growth of certain tumors.

    Glutamine promotes the maintenance of a healthy digestive tract. One of Glutamine's most important tasks in the body is to nourish cells that line the intestine and stomach. Preliminary studies have shown that supplements of Glutamine may protect against aspirin-induced gastric lesions and enhance healing of painful peptic ulcers. It has also been examined for preventing stress ulcers in individuals treated for severe burns. Those with stomach problems associated with Crohn's disease and ulcerative colitis may theoretically benefit from Glutamine too.

    MENTAL FUNCTIONING

    L-Glutamine can enhance mental functioning, and has been used to treat a range of problems including treating weight loss, insomnia, depression, anxiety, developmental disabilities, epilepsy, fatigue, impotence, schizophrenia, and senility.

    L-Glutamine decreases sweets and sugar cravings, which is beneficial to people wishing to lose weight.

    L-Glutamine decreases the desire for alcohol, and is useful for recovering alcoholics. Both Glutamic Acid and GABA are essential for proper mental function. Because of its action in the brain, Glutamine supplements have been recommended for preventing the deleterious effects of alcohol on the brain and for reducing alcohol cravings - a finding that has support in clinical trials.





    GLUTAMINE DOSAGE INFORMATION

    GLUTAMINE FOOD SOURCES

    Many plant and animal substances contain Glutamine, but it is easily destroyed by cooking. If eaten raw, spinach and parsley are good sources. Other Glutamine-rich sources are poultry, fish, meat, beans, milk, and legumes.

    GLUTAMINE SUPPLEMENTS

    Look for Glutamine supplements prefaced by the letter L. This form resembles the Glutamine in the body more than supplements prefaced by the letter D. Supplemental Glutamine must be kept absolutely dry or the powder will degrade into ammonia and pyroglutamic acid.

    Read and follow product label directions if using Glutamine as part of a diet and/or bodybuilding regime. If you are using Glutamine as part of a treatment program, it is recommended you consult with your health care provider for the appropriate dosage. Amino acid supplements prefaced by the letter L, such as L-glutamine, are more similar to the amino acids in the body than those that start with the letter D, with the exception of DL-Phenylalanine, which treats chronic pain.

    Although a Recommended Dietary Allowance (RDA) has not been established for Glutamine, it is critical for optimal health. In the presence of good health, supplementation of Glutamine should not be necessary.


    DOSAGE BY AILMENT

  • Alcoholism: 500 to 1,000 mg L-Glutamine twice a day between meals.
  • Cancer: 1 scoopful (3 to 4 grams) mixed with water 3 to 4 times a day; swish in mouth and swallow. Alternately, 1,500 to 2,000 mg in pills, 4 times a day. All doses taken between meals.
  • Crohn's Disease: 1,000 mg L-Glutamine twice a day.
  • Ulcers: 500 mg L-Glutamine 3 times a day for one month.
  • Weight Loss: 1 teaspoon (4 grams) L-Glutamine powder mixed in water twice a day.


  • This is a generalized recommendation and may not be suitable for everyone. Before starting any new therapy, consult with your health care provider and follow the therapy plan outlined for your specific situation and health requirements.


    GLUTAMINE DEFICIENCY

    Deficiency of this nutrient is rare, since it can be manufactured by the body but deficiencies can develop during periods of fasting, starvation, strict dieting, cirrhosis, and weight loss associated with AIDS and cancer.

  • Glutamine / L-Glutamine Supplements & Products
  • Amino Acid Complex Supplements & Products





  • GLUTAMINE SAFETY, CAUTIONS & INTERACTION INFORMATION

  • Glutamine should not be taken by persons with cirrhosis of the liver, kidney problems, Reye's syndrome, or any type of disorder that can result in an accumulation of ammonia in the blood. For such individuals, taking supplemental glutamine may only cause further damage to the body.

  • Take care not to confuse Glutamine with substances that have similar-sounding names, such as Glutathione, Glutamic Acid, gluten, and monosodium glutamate. Be aware that although the names sound similar, Glutamine, Glutamic Acid (also sometimes called Glutamate), Glutathione, Gluten, and Monosodium Glutamate are all different substances.

  • Some people may experience headaches and other side effects with Glutamine, but much remains to be learned about the potential adverse reactions associated with this supplement. In clinical trials, no toxic reactions were recorded at relatively high doses of 4 to 21 grams (4000 mg to 21,000 mg) a day.

  • If you have any serious illness or are pregnant or breast-feeding, only take an amino acid such as Glutamine after consulting your healthcare provider or midwife.

  • To be safe, never take glutamine - or any single amino acid for that matter - for longer than three months unless you are under the direction of a healthcare provider familiar with its use.

  • Monosodium Glutamate (MSG), a salt of Glutamic Acid, is sometimes used as a condiment for flavoring foods. It imparts no flavor of its own, but enhances the flavors of meats, fish, and vegetables. Some people have an allergic reaction to MSG, and should be avoided by such individuals.

  • GLUTAMINE INTERACTIONS

  • Methotrexate, a drug used to treat certain kinds of cancer, psoriasis, and rheumatoid arthritis, may interfere with glutamine's effectiveness in treating mouth ulcers resulting from cancer chemotherapy.

  • There are no other known drug or nutrient interactions associated with Glutamine.

  • TOXICITY & SYMPTOMS OF HIGH INTAKE

    No clear toxicity has emerged in Glutamine studies, but it should not be taken by people suffering from liver or kidney problems.





    GLUTAMINE AMINO ACID SUPPLEMENT PRODUCTS

  • Glutamine Supplement Products

  • Amino Acid Complex Supplement Products


  • QUALITY SUPPLIES & PRODUCTS


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    GLUTAMINE (L-GLUTAMINE) AMINO ACID SUPPLEMENT PRODUCTS

    L-Glutamine is the most abundant amino acid in plasma and muscle. This brain nutrient sharpens mental function and acuity. It plays an important role in supporting the immune system and the digestive tract. L-Glutamine is an energy source in mitochondria and functions as a critical precursor of important brain neurotransmitters. This brain nutrient sharpens mental function and acuity. L-Glutamine improves muscle metabolism and is important to both athletes and those challenged with muscle loss or muscle wasting concerns. L-Glutamine is important in helping to maintain optimal immune function under heavy stress.

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    AMAZON PRODUCTS

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  • Nutrition Basics: Glutamine Amino Acid Supplement Information



  • AMINO ACID COMPLEX PRODUCTS

    HERBSPRO PRODUCTS

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    HELPFUL RELATED MOONDRAGON NUTRITION BASICS LINKS

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