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A NON-PROTEIN BUILDING BLOCK
Dimethylglycine (DMG) is a derivative of Glycine, the simplest of the amino acids. It is a non-protein amino acid found naturally in animal and plant cells. DMG is produced in cells as an intermediate in the metabolism of Choline to Glycine. It acts as a building block for many important substances, including the amino acid Methionine, Choline, a number of important hormones and neurotransmitters, and DNA.
There has been much confusion surrounding the history of DMG as a nutritional supplement. DMG appeared as a supplement in the 1960s under the names Vitamin B-15, pangamic acid and calcium pangamate. Calcium pangamate was originally a mixture of calcium gluconate and DMG. Calcium pangamate was intended as a delivery form of DMG. However, several products entered the supplement marketplace called pangamic acid or calcium pangamate, and these did not contain DMG. Some of these products contained, instead of DMG, a substance called diisopropylammonium dichloroacetate. At present, DMG supplements are available that do contain dimethylglycine.
DMG-containing calcium pangamate was popular with Russian athletes and cosmonauts because it was reputed to enhance oxygenation at the cellular level, reduce fatigue and enhance physical stamina. None of those claims, however, was ever substantiated. DMG is neither a vitamin nor an essential nutrient. DMG is also known as N, N-dimethylglycine, (dimethylamino) acetic acid and N-methylsarcosine.
DMG is a solid, water-soluble substance. DMG should not be confused with TMG (trimethylglycine or betaine). TMG is involved in the methylation of homocysteine to form methionine (See Trimethylglycine). DMG can be formed from TMG upon the loss of one of its methyl groups.
DMG is absorbed from the small intestine and from there transported by the portal circulation to the liver. DMG is swiftly metabolized in the liver converting dimethylglycine into other useful metabolites by means of oxidative dimethylation. DMG metabolizes to monomethylglycine or sarcosine which, in turn, is converted to glycine. Dimethylglycine dehydrogenase, a flavoprotein, is the enzyme that catalyzes the oxidative demethylation of DMG to sarcosine. The methyl group produced in this reaction returns to the one carbon pool at the level of N10-hydroxymethyl-tetrahydrofolic acid. DMG itself is formed from trimethylglycine or betaine. DMG that is not metabolized in the liver is transported by the circulatory system to various tissues in the body. There are no known deficiency symptoms due to a lack of DMG in the diet; however, taking this amino acid does offer a wide range of health benefits.
DMG serves as a building block to amino acids, hormones, neurotransmitters, and even DNA. Taking supplemental DMG can have a wide range of possible beneficial effects. DMG has been suggested for use as an athletic performance enhancer, immunostimulant, and a treatment for autism, epilepsy, or mitochondrial disease. It is thought to be a metabolic enhancer and aid in processes associated with those included in cellular respiration, immune response, and oxygen utilization within the body. It helps the body maintain high energy levels and boost mental acuity. DMG has been found to enhance the immune system and to reduce elevated blood cholesterol and triglyceride levels. It improves oxygen utilization by the body, helps to normalize the functioning of many important organs. Dimethylglycin may also play equally important roles in the prevention of fatigue and improvements in liver function. It may also be useful for controlling epileptic seizures.
Trimethylglycine (TMG) is found in a variety of plant and animal sources and is utilized in the conversion of homocysteine to Methionine. Maintaining normal homocysteine levels is important for the health of the cardiovascular system. TMG helps convert homocysteine to Methionine by donating a methyl (CH3) group.
Reducing Homocysteine Levels with Trimethylglycine: Elevated homocysteine levels are easily reduced with the intake of certain nutrients involved in methylation. Such nutrients include Folic Acid with its cofactors, Vitamin B-6 and Vitamin B-12, plus what is proving to be the most efficient and cost-effective methyl donor of all, Trimethylglycine (TMG).
TMG (also known as anhydrous betaine) is a naturally occurring phytonutrient found in a variety of plants and animals, with highest concentrations in beets, leafy green vegetables, and legumes. Since it can be difficult to eat enough of these foods to provide the body with sufficient methyl groups, supplementation may be necessary. Studies have demonstrated that TMG, folic acid, and B-12 can reduce elevated levels of homocysteine to normal. The best methyl donor is TMG, because it has 3 methyl groups. Furthermore, after losing its methyl group, TMG becomes DMG (dimethylglycine), a well recognized energy-boosting nutrient. For more information about TMG, See:
MoonDragon's Nutrition Basics Information: Amino Acids - TMG (Trimethylglycine) Information
DMG Dimethylglycine Supplements & Products TMG Trimethylglycine Supplements & Products
DMG USES, HEALTH BENEFITS & SCIENTIFIC EVIDENCE
DMG has been found to boost the immune system and is good for the heart. It has been found to lower elevated blood cholesterol and triglycerides, and help reduce and normalize blood pressure and blood glucose. This amino acid helps the body maintain its energy levels and helps mental acuity. While it helps balance blood pressure and blood glucose levels, it improves oxygen utilization by the body. DMG may even be useful in controlling epileptic seizures. DMG also acts as a detoxifying agent and antioxidant, protecting body cells from unwanted reactions caused by free radicals.
The Journal of Infectious Diseases reported a study done by the Medical University of South Carolina; that in a double blind study DMG increases antibody production by more than 400-percent in humans. DMG also stimulates both the antibody response and cellular immunity branches of the immune system. Later research by the Clemson University confirmed the findings.
It has also been found that DMG is useful in Autism. Though the research still needs to be done: Many parents have reported that, within a few days of starting DMG, the child's behavior improved noticeably, better eye contact was seen, frustration tolerance increased, the child's speech improved, or more interest and ability in speaking was observed.
DIMETHYLGLYCINE (DMG) & AUTISM
Written by Stephen M. Edelson, Ph.D., Center for the Study of Autism, Salem, Oregon
DMG is another nutrient that, according to reports from thousands of families, is quite beneficial to many autistic individuals. Similar to vitamin B-6 and magnesium, DMG is safe, relatively inexpensive, and helps about half of autistic children and adults.
Research on humans and laboratory animals have shown that DMG strengthens the immune system. The immune system is dysfunctional in many autistic individuals. Some autistic children and adults have seizures, and there are two published reports of decreases in seizure activity as a result of DMG (New England Journal of Medicine, 1982, 307, 1081-1082; Epilepsia, 1989, 30, 90-93).
Two studies have shown no improvements from DMG in autistic individuals; however, at least one of the studies used only half the recommended dose. A recent double-blind placebo-controlled study involving 84 participants documented a significant decrease in behavior problems (Unpublished study by doctors Shin-siung Jung, Bernard Rimland, and Stephen M. Edelson).
The recommended daily dose of DMG is between one to four 125 mg tablets for a child, and between two and eight tablets for an adult. Initially, a person should begin with one 125 mg tablet (a ½ tablet for a small child), and then increase the amount by one tablet every 2 to 3 days. DMG is also available in capsule, liquid, and sweet-tasting dissolving tablets.
There are no documented long-term side effects from DMG; however, in a few cases, parents report agitation and/or hyperactivity in their children. In these cases, it is recommended that folic acid also be given to the person. The suggested amount is two 800 microgram tablets for each 125 mg tablet of DMG. Some professionals suggest that DMG should always be supplemented with folic acid since folic acid cannot cause any harm, reduces the possibility of agitation/hyperactivity, and could possibly be more effective than when giving DMG alone.
Parents have also reported positive results with a similar product, Trimethylglycine (TMG). There are, as yet, no published reports on its efficacy for autistic individuals. TMG breaks down into DMG and SAM-e in the body. SAM-e is a nutritional supplement and is sometimes used to treat mood disorders such as depression.
Dimethylglycine (DMG): Autism
DMG DOSAGE INFORMATION
DMG FOOD SOURCES
DMG is found in beans and liver and in low levels in meats, seeds, and grains. However, this amino acid can be taken as a daily dietary supplement. Read and follow product label recommendations.
DMG comes in tablets, capsules, and other preparations, typically at a dosage of 125 mg.
Use of DMG should be restricted to items specifically labeled DMG or dimethylglycine. Items labeled pangamic acid, calcium pangamate and vitamin B15 should be avoided. DMG comes in tablets, capsules and sublingual preparations, typically at a dose of 125 mg. The usual dose is 125 mg daily with meals.
DMG SAFETY, CAUTIONS & INTERACTION INFORMATION
Contraindications: Those with hypersensitivity to any component of the preparation should not use DMG.
Precautions: DMG is not advised for pregnant women or nursing mothers and should only be used in children under medical supervision.
Adverse Reactions: Those with the rare disorder of dimethylglycine dehydrogenase deficiency may complain of a fish odor when taking DMG supplements. No other significant adverse reactions have been reported with DMG. DMG is completely safe as a supplement in your daily diet because it does not build up within the body. There are no deficiency symptoms if the diet is lacking in DMG.
Interactions: There are no known drug, nutritional supplement, food or herb interactions. There is no known interaction with alcohol.
Overdose: There are no known reports of overdose with DMG.
DMG AMINO ACID SUPPLEMENT PRODUCTS
QUALITY SUPPLIES & PRODUCTS
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DMG (N,N DIMETHYL GLYCINE) SUPPLEMENT PRODUCTS
DMG is a methylated amino acid supplement found in all cells. DMG is an antioxidant and methyl donor that has a number of beneficial effects. It has shown to have potential in increasing immune response to the flu and salmonella. DMG enhances both cellular and humoral immunity. DMG helps transport oxygen into cells, increasing their efficiency and preventing lactic acid build-up. DMG supplements have been used in studies of autism with some experiences of improvement. Results will usually show up within a week though it may range from one day to several weeks. Similarly, in some children with Attention Deficit Disorder (ADD), DMG supplements have improved behavior, speech and frustration threshold within 24 hours.
HerbsPro: Aangamik DMG Liquid, FoodScience of Vermont, 300 mg, 2 fl. oz. (35033)
HerbsPro: DMG-B15 Plus, Enzymatic Therapy, 60 Caps (13017)
DMG-B15-Plus contains essential nutrients for the heart: potassium, magnesium, and calcium. Potassium is well-known for maintaining healthy blood pressure levels that are already within the normal range. Magnesium is involved in membrane integrity, muscle contraction, and vascular tone. Researchers continue to explore the connection between calcium and cholesterol levels. DMG-B15-Plus also supplies dimethylglycine (DMG) and trimethylglycine (TMG), which is converted to DMG in the liver. DMG is an intermediary of cell metabolism that may help the body use oxygen more efficiently.
HerbsPro: DMG (N,N-Dimethylglycine), Immune Response Support, Source Naturals, 100 mg, 30 Tabs (6804)
HerbsPro: DMG (N,N-Dimethylglycine), Immune Response Support, Source Naturals, 100 mg, 60 Tabs (6805)
HerbsPro: Aangamik DMG, FoodScience of Vermont, 125 mg, 60 Tabs (15157)
HerbsPro: Aangamik DMG, FoodScience of Vermont, 125 mg, 90 Tabs (15158)
HerbsPro: Aangamik DMG, FoodScience of Vermont, 250 mg, 60 Chewable Tabs (15151)
HerbsPro: Aangamik DMG, FoodScience of Vermont, 250 mg, 90 Chewable Tabs (15152)
HerbsPro: Aangamik DMG, FoodScience of Vermont, 500 mg, 60 Chewable Tabs (61523)
HerbsPro: Aller-DMG, FoodScience of Vermont, 60 Tabs (61524)
Aller-DMG is a dietary supplement to support respiratory and nasal comfort as well as skin health. Aller-DMG is an advanced supplement that supports healthy histamine levels and immune system function. Aller-DMG vegetarian tablets are enteric coated to ensure optimal absorption of all the nutrients.
HerbsPro: Behavior Balance DMG, FoodScience of Vermont, 120 VCaps (35034)
HerbsPro: Behavior Balance DMG Liquid, FoodScience of Vermont, 12 oz. (61525)
HerbsPro: Cardio-DMG, FoodScience of Vermont, 90 Tabs (35037)
A dietary supplement to support health and circulatory functions and healthy management of homocysteine and cholesterol levels within normal ranges. Cardio-DMG is a combination of N,N-Dimethylglycine (DMG), Acetyl-L-Carnitine, Coenzyme Q10, Magnesium and Potassium Citrates, Vitamin B6, Vitamin B12, Folic Acid, and Betaine. Cardio-DMG is a nutritional supplement specifically formulated to support heart function by maintaining healthy cholesterol and triglyceride levels, oxygen utilization, proper circulation, and help regulate homocysteine and blood pressure levels within normal ranges. Acetyl-L-Carnitine is a derivative of the amino acid, carnitine. It supports heart function by transporting fatty acids from the blood through to the mitochondrial membranes and into heart cells so the fatty acids can be converted into energy fuel called ATP (Adenosine Triphosphate). Acetyl-L-Carnitine helps to relieve toxic fatty acid metabolites from damaging heart cell membranes. DMG has many properties to enhance cardiovascular health including improving circulation, enhancing oxygen utilization, supporting cholesterol and tryglyceride levels including increasing HDL levels and aiding in the reduction of homocyteine by providing methyl groups for SAMe production. Research suggests that supplementation with Acetyl-L-Carnitine, CoQ10, Magnesium, Dimethylglycine, and Vitamin B6 may improve fat metabolism. More Coenzyme Q10 is found in the heart muscle than in any other muscle in the body. In heart tissue, a Q10 deficiency may lead to cardiovascular dysfunction. Potassium is a mineral and an electrolyte. Electrolyte balance has a regulating effect on heart rhythm, so potassium is very important. Potassium has been shown to regulate blood pressure, which benefits cardiovascular function. Vitamin B12 and Folic Acid are necessary to turn homocysteine into methionine and this allows the body to recycle or remove homocysteine as needed. Betaine breaks down fat and removes it from the body to improve circulation, maintain balanced cholesterol levels, and to help protect the liver from fat deposits. Deficiencies of magnesium are asscociated with high blood pressure, irregular heartbeat and rhythm, poor muscle contraction, and cardiovascular dysfunction.
HerbsPro: Fibro-My-DMG, FoodScience of Vermont, 90 Tabs (35038)
A dietary supplement to support muscle and immune system functions, proper mood balance, and stress management. Fibro-My-DMG is an advanced nutritional supplement that combines N,N-Dimethylglycine (DMG), Malic Acid, GABA, NADH, and Magnesium. These nutrients work synergistically to support proper mood balance, help cope with stress, reduce muscle aches, and support immune system function. Fibro-My-DMG is designed for individuals experiencing constant muscle ache and stiffness, fatigue, and sleeping problems. Besides being a major immune modulator, DMG aids mental acuity and provides a major boost to overcoming fatigue and muscle cramping. DMG enhances endurance, stamina, and helps reduce stress on the body and provides better quality of sleep.
HerbsPro: Immuno-DMG, FoodScience of Vermont, 90 Tabs (35039)
HerbsPro: Maitake DMG Liquid, FoodScience of Vermont, 120 ml (70188)
Maitake-DMG Liquid is a combination of two well-researched nutrients for immune system support. Maitake PD-Fraction is a standardized extract of Maitake mushroom that contains the D-Fraction, one of nature's most comprehensive immune support compounds. This extract combined with our patented Aangamik DMG, which is well-known for its immunoproperties and may play a significant role in maintaining health by supporting the body's immune system functions. Together these two potent nutrients help support immune system function and help maintain optimal health.
HerbsPro: Neuro-DMG, FoodScience of Vermont, 90 Tabs (35041)
A dietary supplement to support brain and neurological functions. Neuro-DMG is a nutritional supplement specifically formulated to support and enhance brain function. This formula was designed for individuals who have difficulty with memory or recall thought focus, and following information or conversations. DMG supports brain neurotransmitter production, oxygen uptake, circulation to the brain, and reduces the negative metabolic effects of external stressors. Glutamine is known as a free amino acid and has the ability to provide nutrition to brain cells allowing for improved mental alertness, memory, mood, and mental clarity. It can readily pass through the blood-brain barrier and is considered a brain fuel. It is then converted to glutamic acid, which acts as a neurotransmitter in the brain. Glutamine also increases GABA production, which is needed for proper brain function.
HerbsPro: Aangamik Gluta-DMG Powder, FoodScience of Vermont, 408.6 Grams 30 Servings (35032)
Aangamik Gluta-DMG is a dietary supplement to support immune system and liver functions and muscle recovery. A superior Whey Protein Isolate product that contains sub-families of bioactive proteins, such as Lactoferrin, alpha-Lactoalbumin and Serum Albumin, which have high levels of glutathione precursors (building blocks) found when compared to other whey proteins and casein. Combined with DMG, the immune enhancement, detoxification, improved muscular response, and antioxidant activity leads to a synergistic product of superior activity.
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Nutrition Basics: TMG (Trimethylglycine) Amino Acid Supplement Information Nutrition Basics: DMG (Dimethylglycine) Amino Acid Supplement Information
TMG (TRIMETHYLGLYCINE) SUPPLEMENT PRODUCTS
Source Naturals is dedicated to bringing you the finest nutrients modern research has to offer, including detailed information on how they function in the human body. Compelling research reveals how TMG supports the health of blood vessels. Considering the circulatory system's vulnerability today, this important nutritional supplement seems destined to become a mainstay in health programs of the next century. Start building your nutritional bridge to a healthy future with Trimethylglycine. Source Naturals TMG Trimethylglycine is suitable for vegetarians and Hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance. For daily maintenance, take one to two TMG tablets. To support lower homocysteine levels, take two to four TMG tablets daily. Warning: If you are pregnant or breastfeeding, consult your health care professional before using TMG Trimethylglycine product.
HerbsPro: TMG Powder, Life Extension, 50 Grams (91786)
HerbsPro: TMG Crystals Powder, Jarrow Formulas, 50 Grams (2754)
HerbsPro: TMG-500, Jarrow Formulas, 500 mg, 120 Tabs (1138)
HerbsPro: TMG, Life Extension, 500 mg, 180 Tabs (91789)
HerbsPro: TMG (Trimethylglycine), Source Naturals, 750 mg, 60 Tabs (6678)
HerbsPro: TMG (Trimethylglycine), Source Naturals, 750 mg, 120 Tabs (6679)
HerbsPro: TMG (Trimethylglycine), Source Naturals, 750 mg, 240 Tabs (6680)
HerbsPro: TMG (Trimethylglycine), Now Foods, 1000 mg, 100 Tabs (68816)
Amazon: Dimethylglycine (DMG) Supplement Products
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Nutrition Basics: TMG (Trimethylglycine) Amino Acid Supplement Information Nutrition Basics: DMG (Dimethylgylcine) Amino Acid Supplement Information
AMINO ACID COMPLEX PRODUCTS
HerbsPro: Amino-9 Essentials Powder, Now Foods, 330 Grams
Complete Free Form blend of all 9 essential amino acids. Dietary supplements helpful in sports. GMP quality assured.
HerbsPro: Amino Balance Powder, Free Form Amino Acid Complex, Anabol Naturals
HerbsPro: Amino Balance Powder, Free Form Amino Acid Complex, Anabol Naturals, 500 grams
HerbsPro: Amino Balance, Free Form Amino Acid Complex, Anabol Naturals, 500 mg, 120 Caps
HerbsPro: Amino Balance, Free Form Amino Acid Complex, Anabol Naturals, 500 mg, 240 Caps
HerbsPro: Amino Balance, Free Form Amino Acid Complex, Anabol Naturals, 500 mg, 500 Caps
For tissue repair, reduced soreness and accelerated recovery, as well as a wealth of non-training benefits, this blend of 23 pure crystalline 100% pharmaceutical grade free-form amino acids is unmatched.
HerbsPro: Amino Max 21, FoodScience of Vermont, 90 Caps
A high quality, hypoallergenic amino acid formulation. Amino Max 21 is a scientifically formulated combination of 21 crystalline, free-form amino acids in the natural L-configuration. Because free-form amino acids are readily bioavailable and require no digestion by the body, they can be absorbed efficiently into the bloodstream and accompanying tissues where they are used for cellular regeneration.
HerbsPro: Essential Amino Acid Complex, Solgar, Free Form, 600 mg, 90 VCaps (36384)
HerbsPro: Amino Complete, Balanced Blend Complex, Now Foods, 120 Caps
HerbsPro: Max-Amino With Vitamin B-6, Blend of 18 Amino Acids, Country Life, 180 Caps
An easily absorbed blend of 18 amino acids yielding high biological activity. An ideal formula for athletes, and when protein demands may not be fully satisfied. B-6 aids in the utilization of amino acids. An easily absorbed Amino Acid Supplement.
HerbsPro: Amino Acid Complete, Balanced Blend Complex, Now Foods, 360 Caps
HerbsPro: Cher-Amino Liquid Protein, TwinLab, 16 fl. oz. (19499)
Cher Amino Protein is a concentrated and peptide bonded free amino acid supplement contains all essential amino acid derived from natural enzyme hydrolysis of collagen protein and whey protein that help relieve muscle breakdown.
HerbsPro: Cher-Amino Liquid Protein, TwinLab, 32 fl. oz. (19498)
Cher Amino Protein is a concentrated and peptide bonded free amino acid supplement contains all essential amino acid derived from natural enzyme hydrolysis of collagen protein and whey protein that helps to relieve muscle breakdown. The protein in this product is a predigested collagen and whey (lactalbumin) protein and is therefore utilized 100%. Contains all the essential amino acids derived by enzymatically hydrolyzing the animal protein collagen and whey protein (lactalbumin). The amino acids in this product are naturally present in the protein. They are not added or manufactured. 15 grams per ounce. New improved formula. Predigested collagen. Enriched with predigested whey protein, a superior source of high quality amino acids.
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Nutrition Basics: Amino Acid Complex Supplement Information
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