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MoonDragon's Health & Wellness
Nutrition Basics

Amino Acids
DMAE

Dimethylaminoethanol


For Informational Use Only
For more detailed information contact your health care provider
about options that may be available for your specific situation.





  • DMAE Description
  • DMAE Uses, Health Benefits & Scientific Evidence
  • DMAE Dosage Information
  • DMAE Safety, Cautions & Interactions
  • DMAE (Dimethylaminoethanol) Supplement Products




  • DMAE DESCRIPTION

    A PRIMARY ALCOHOL

    Dimethylaminoethanol, also known as DMAE or dimethylethanolamine, is a primary alcohol. This compound also goes by the names of N,N-dimethyl-2-aminoethanol, beta-dimethylaminoethyl alcohol, beta-hydroxyethyldimethylamine and Deanol. It is a transparent, pale-yellow liquid.

    DMAE (Dimethylaminoethanol) is a chemical naturally produced in small amounts in the human brain, and is found in high levels in anchovies and sardines. Initially, drug makers wanted to sell DMAE as a medication for attention deficit disorder (ADD) when studies in the 1970s showed that deanol, the chemical name for DMAE, reduced hyperactivity and improved concentration in schoolchildren with learning disabilities and behavior problems; however, further testing was considered too expensive, so it was then promoted as a nutritional supplement.

    BIOCHEMICAL PRECURSOR

    Dimethylaminoethanol is related to choline and may be a biochemical precursor to the neurotransmitter acetylcholine, although this conclusion has been disputed. It is commonly believed that dimethylaminoethanol is methylated to produce choline in the brain, but this has been shown not to be the case. It is known that dimethylaminoethanol is processed by the liver into choline; however, the choline molecule is charged and cannot pass the blood–brain barrier. In the brain, DMAE is instead bound to phospholipids in place of Choline to produce Phosphatidyl-Dimethylaminoethanol. This is then incorporated into nerve membranes, increasing fluidity, permeability, and acting as an antioxidant.





    DMAE USES, HEALTH BENEFITS & SCIENTIFIC EVIDENCE

    RESEARCH STUDIES

    Short-term studies have shown an increase in vigilance and alertness with a positive influence on mood following administration of DMAE, vitamins, and minerals in individuals suffering from borderline emotional disturbance. Research for attention deficit hyperactivity disorder (ADHD) has been promising, though inconclusive. A study showed dimethylaminoethanol to decrease the average life span of quail.


    ADHD & MEMORY LOSS

    There is currently a lack of scientific research on the health effects of DMAE. One of the few available reports is a small study published in the European Journal of Medical Research in 2003. For the study, 80 people (all of whom were known to have "borderline emotional disturbance") took either a placebo or a supplement containing vitamins, minerals, and DMAE every day for three months. Six weeks into the study, all participants were shown film excerpts with a range of emotional content. After another six weeks, participants were shown the film excerpts again. Looking at data on the study participants, researchers found that those who took the vitamin/mineral/DMAE supplements had a greater increase in wellbeing than those who took the placebo. Members of the treatment group also appeared to experience improvements in mood and attention. Given these findings, the study's authors suggest that use of DMAE supplements may be of some benefit to people experience emotional disturbance.

    Scientific evidence suggests DMAE may have benefits against the impulsive and disruptive behaviors caused by attention deficit hyperactivity disorder (ADHD), but it may also play a role in treating ordinary memory lapses that occur with age, and the effects of memory loss associated with Alzheimer's disease. Although thorough studies are incomplete, some people report better memory (especially short-term memory), as well as improved concentration, focus, mental clarity, and sleep after taking DMAE.

    A recent German study evaluated the brain's electrical reaction during video clips. Half of the subjects were then started on a daily dose of DMAE and testing repeated after twelve weeks. The results showed that those who took the DMAE daily were more alert. Furthermore, the questionnaires that were given out revealed that those on DMAE had a better mood. The researchers concluded, "DMAE can be interpreted to induce a psycho physiological state of better feeling of well-being on both levels of analysis mood and electrical pattern of brain activity."

    DERMATOLOGIC BENEFITS

    DMAE is a natural compound sometimes used as an ingredient in skin care products. DMAE cream, DMAE lotion, and other DMAE-based skin-care products are said to offer anti-aging benefits. While research on DMAE's effectiveness in skin-care is fairly limited, there's some evidence that using DMAE-based products may help improve skin. In 2005 it was reported in a research review from the American Journal of Clinical Dermatology that the benefits of DMAE in dermatology include a potential anti-inflammatory effect and a documented increase in skin firmness with possible improvement in underlying facial muscle tone. In their analysis of previously published research on the use of DMAE in skin care, the review's authors found that DMAE als may help reduce fine lines and improve the overall appearance of aging skin. The review's authors also note that DMAE does not appear to cause adverse effects such as peeling and dryness.

    INDUSTRIAL USES OF DMAE

    Dimethylaminoethanol is used as a curing agent for polyurethanes and epoxy resins. It is also used in mass quantities for water treatment, and to some extent in the coatings industry. It is used in the synthesis of dyestuffs, textile auxiliaries, pharmaceuticals, emulsifiers, and corrosion inhibitors. It is also an additive to paint removers, boiler water and amino resins. It forms a number of salts with melting points below room temperature (ionic liquids) such as N,N-dimethylethanolammonium acetate and N,N-dimethylethanolammonium octanoate, which have been used as alternatives to conventional solvents.

    2-Dimethylaminoethyl chloride hydrochloride is an intermediate made from dimethylaminoethanol that is widely used for the manufacture of pharmaceuticals.


    REFERENCES

    1. Littel, RJ, Bos, M, Knoop, GJ (1990). "Dissociation constants of some alkanolamines at 293, 303, 318, and 333 K". J. Chem. Eng. Data 35: 276–277.
    2. Sanders MW, Wright L, Tate L, Fairless G, Crowhurst L, Bruce NC, Walker AJ, Hembury GA, Shimizu S (September 2009). "Unexpected preferential dehydration of artemisinin in ionic liquids". J. Phys. Chem. A 113 (38): 10143–45.
    3. Ashford's Dictionary of Industrial Chemicals, 3rd edition, 2011, ISBN 978-0-9522674-3-0, page 3294
    4. Zahniser NR, Chou D, Hanin I (March 1977). "Is 2-dimethylaminoethanol (deanol) indeed a precursor of brain acetylcholine? A gas chromatographic evaluation". J. Pharmacol. Exp. Ther. 200 (3): 545–59.
    5. Zs-Nagy, I (1989). "On the role of intracellular physicochemistry in quantitative gene expression during aging and the effect of centrophenoxine. A review.". Archives of gerontology and geriatrics 9 (3): 215-229.
    6. Dimpfel W, Wedekind W, Keplinger I (May 2003). "Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states". Eur. J. Med. Res. May 30; 8 (5): 183–91.
    7. Knobel M (1974). "Approach to a combined pharmacologic therapy of childhood hyperkinesis". Behav Neuropsychiatry 6 (1–12): 87–90.
    8. Cherkin A, Exkardt MJ (January 1977). "Effects of dimethylaminoethanol upon life-span and behavior of aged Japanese quail". J Gerontol 32 (1): 38–45.
    9. Grossman R. "The role of dimethylaminoethanol in cosmetic dermatology." Am J Clin Dermatol. 2005;6(1):39-47.

    STUDIES

  • Earliest Research: Pfeiffer CC, Jenney EH, Gallagher W, et al. (September 1957). "Stimulant effect of 2-dimethylaminoethanol; possible precursor of brain acetylcholine". Science 126 (3274): 610–1.
  • As A Treatment For Tardive Dyskinesia: Haug BA, Holzgraefe M (1991). "Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol (deanol)?". Eur. Neurol. 31 (6): 423–5.
  • As An Unsuccessful Treatment For Alzheimer's Disease: Fisman M, Mersky H, Helmes E (July 1981). "Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease". Am J Psychiatry 138 (7): 970–2.





  • DMAE DOSAGE INFORMATION

    SUPPLEMENT FORMS

    DMAE is a nutritional supplement available in capsule, tablet and liquid forms.

    The recommended dose of DMAE for ADHD 100 to 300 mg, taken orally twice a day. For memory problems or Alzheimer's the recommended dose is 100 to 300 mg, taken orally twice a day. Take with meals for best absorption.

  • DMAE (Dimethylaminoethanol) Supplements & Products





  • DMAE SAFETY, CAUTIONS & INTERACTION INFORMATION

    SAFETY CONCERNS

    DMAE supplements will not work for everybody. DMAE is not intended to be a cure; however, it may be helpful. Maximum safe dosages for children or for pregnant or nursing mothers is not known. To avoid DMAE side effects take the recommended dose. High doses can cause anxiety, restlessness and muscle tenderness in the neck and shoulders.

    SIDE EFFECTS

    Very little is known about the safety of long-term use of DMAE supplements. However there is some concern that DMAE may trigger certain side effects, including increased blood pressure, stomach upset, drowsiness, confusion, and irritability. If you are considering the use of DMAE supplements, talk to your health care practitioner before starting your supplement regimen.





    DMAE AMINO ACID SUPPLEMENT PRODUCTS

  • DMAE Supplement Products

  • Amino Acid Complex Supplement Products


  • QUALITY SUPPLIES & PRODUCTS


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    DMAE (DIMETHYLAMINOETHANOL) SUPPLEMENT PRODUCTS

    DMAE (Dimethylaminoethanol) is a chemical naturally produced in the human brain. It is thought to be used by the body in converting the precursor choline to the neurotransmitter, acetylcholine. This is the basis for the reasoning behind the theory that supplementing with DMAE will enhance brain activity .

    HERBSPRO PRODUCTS

    HerbsPro: DMAE - H3 Liquid Supplement, TwinLab, 1.66 fl. oz. (19574)
    DMAE-H3 is a concentrated solution of the PABA (para-aminobenzoic acid) salt of DMAE stabilized with benzoic acid. DMAE (dimethylaminoethanol) by itself is alkaline and caustic. Therefore, only salts and esters of DMAE are used. DMAE naturally occurs as liquid in its concentrated form. DMAE naturally occurs in fish.
    HerbsPro: DMAE, BlueBonnet, 100 mg, 50 VCaps (100825)
    HerbsPro: DMAE, TwinLab, 100 mg, 100 Caps (19573)
    HerbsPro: DMAE, BlueBonnet, 100 mg, 100 VCaps (100826)
    HerbsPro: DMAE Bitartrate, Life Extension, 150 mg, 200 Caps (91772)
    HerbsPro: DMAE, Thompson Nutritional Products, 250 mg, 60 Caps (38816)
    HerbsPro: DMAE, Now Foods, 250 mg, 100 VCaps (68061)
    HerbsPro: DMAE, Country Life, 350 mg, 50 Caps (37143)
    HerbsPro: DMAE (Dimethylaminoethanol Bitartrate), Source Naturals, 351 mg, 50 Tabs (6801)
    HerbsPro: DMAE (Dimethylaminoethanol Bitartrate), Source Naturals, 351 mg, 50 Caps (31684)
    HerbsPro: DMAE (Dimethylaminoethanol Bitartrate), Source Naturals, 351 mg, 100 Tabs (6802)
    HerbsPro: DMAE (Dimethylaminoethanol bitartrate), Source Naturals, 351 mg, 200 Tabs (6803)
    HerbsPro: Ageless Mind With DMAE, Source Naturals, 180 Tabs (89096)
    Source Naturals Ageless Mind is a comprehensive formula for the brain that provides ingredients that support brain health and cognitive function, including memory and concentration. Preliminary research shows that the ingredients in Ageless Mind support natural biochemical cycles of beta-amyloid clearance.
    HerbsPro: Added Attention With DMAE, Buried Treasure, 16 fl. oz. (50979)
    ADD Attention, Children's Concentration Formula provides the special dietary needs of highly active children for B vitamins, DHA, DMAE, and trace minerals. The child with learning difficulties and lack of concentration needs ADD Attention to support his ability to focus. Rich in nutrients necessary for increased concentration and mental focus. Bio-Blending process assures easy absorption and assimilation of nutrients by children. Rich source of DHA! Good tasting and easy-to-swallow liquid form.
    HerbsPro: DMAE Firming Fluid, Reviva, 1 fl. oz. (38785)
    HerbsPro: Alpha Lipoic Acid Firming Eye Serum, Vitamin C & DMAE, Reviva, 1 oz. (35481)
    HerbsPro: Skin Eternal DMAE Serum, Source Naturals, 1 fl. oz. (31757)
    HerbsPro: Skin Eternal DMAE Serum, Source Naturals, 1.7 fl. oz. (31758)
    HerbsPro: DMAE Alpha Lipoic C-Ester Serum, Derma-E, 2 oz. (67172)
    HerbsPro: Hyaluronic DMAE Lift & Firm Cream, Age Defying, Andalou Naturals, 1.7 oz. (108499)
    HerbsPro: Skin Eternal DMAE Cream, Source Naturals, 2 oz. Jar (70048)
    Source Naturals Skin Eternal DMAE Cream contains a high potency of DMAE, shown in research to increase skin firmness. It also contains lipoic acid, ascorbyl palmitate (C-Ester), CoQ10, MSM and other skin supporting nutrients and plant extracts in a rich and luxurious base. DMAE cream helps your skin feel more supple and replenished without a lingering oily feeling. It has a fresh light scent.
    HerbsPro: DMAE Alpha Lipoic C-Ester Creme, Derma-E, 2 oz. (50362)
    HerbsPro: Alpha Lipoic Acid Night Cream With DMAE & Vitamin C, Reviva, 0.25 oz. (12 Pack) (89047)
    HerbsPro: Alpha Lipoic Acid Night Cream With DMAE & Vitamin C Ester, Reviva, 2 oz. (35479)
    HerbsPro: DMAE Alpha Lipoic C-Ester Cleanser, Derma-E, 4 oz. (67169)
    HerbsPro: DMAE Alpha Lipoic C-Ester Toner, Derma-E, 6 oz. (67170)
    HerbsPro: Alpha Lipoic Acid Hand & Body Lotion With Vitamin C Ester & DMAE, Reviva, 8 oz. (35480)


    AMAZON PRODUCTS

    Amazon: DMAE Supplement Products
    Amazon: Dimethylaminoethanol (DMAE) Supplement Products

  • Nutrition Basics: DMAE Supplement Information



  • AMINO ACID COMPLEX PRODUCTS

    HERBSPRO PRODUCTS

    HerbsPro: Amino-9 Essentials Powder, Now Foods, 330 Grams
    Complete Free Form blend of all 9 essential amino acids. Dietary supplements helpful in sports. GMP quality assured.
    HerbsPro: Amino Balance Powder, Free Form Amino Acid Complex, Anabol Naturals
    HerbsPro: Amino Balance Powder, Free Form Amino Acid Complex, Anabol Naturals, 500 grams
    HerbsPro: Amino Balance, Free Form Amino Acid Complex, Anabol Naturals, 500 mg, 120 Caps
    HerbsPro: Amino Balance, Free Form Amino Acid Complex, Anabol Naturals, 500 mg, 240 Caps
    HerbsPro: Amino Balance, Free Form Amino Acid Complex, Anabol Naturals, 500 mg, 500 Caps
    For tissue repair, reduced soreness and accelerated recovery, as well as a wealth of non-training benefits, this blend of 23 pure crystalline 100% pharmaceutical grade free-form amino acids is unmatched.
    HerbsPro: Amino Max 21, FoodScience of Vermont, 90 Caps
    A high quality, hypoallergenic amino acid formulation. Amino Max 21 is a scientifically formulated combination of 21 crystalline, free-form amino acids in the natural L-configuration. Because free-form amino acids are readily bioavailable and require no digestion by the body, they can be absorbed efficiently into the bloodstream and accompanying tissues where they are used for cellular regeneration.
    HerbsPro: Essential Amino Acid Complex, Solgar, Free Form, 600 mg, 90 VCaps (36384)
    HerbsPro: Amino Complete, Balanced Blend Complex, Now Foods, 120 Caps
    HerbsPro: Max-Amino With Vitamin B-6, Blend of 18 Amino Acids, Country Life, 180 Caps
    An easily absorbed blend of 18 amino acids yielding high biological activity. An ideal formula for athletes, and when protein demands may not be fully satisfied. B-6 aids in the utilization of amino acids. An easily absorbed Amino Acid Supplement.
    HerbsPro: Amino Acid Complete, Balanced Blend Complex, Now Foods, 360 Caps
    HerbsPro: Cher-Amino Liquid Protein, TwinLab, 16 fl. oz. (19499)
    Cher Amino Protein is a concentrated and peptide bonded free amino acid supplement contains all essential amino acid derived from natural enzyme hydrolysis of collagen protein and whey protein that help relieve muscle breakdown.
    HerbsPro: Cher-Amino Liquid Protein, TwinLab, 32 fl. oz. (19498)
    Cher Amino Protein is a concentrated and peptide bonded free amino acid supplement contains all essential amino acid derived from natural enzyme hydrolysis of collagen protein and whey protein that helps to relieve muscle breakdown. The protein in this product is a predigested collagen and whey (lactalbumin) protein and is therefore utilized 100%. Contains all the essential amino acids derived by enzymatically hydrolyzing the animal protein collagen and whey protein (lactalbumin). The amino acids in this product are naturally present in the protein. They are not added or manufactured. 15 grams per ounce. New improved formula. Predigested collagen. Enriched with predigested whey protein, a superior source of high quality amino acids.


    AMAZON PRODUCTS

    Amazon: Amino Acid Complex Complete Supplement Products

  • Nutrition Basics: Amino Acid Complex Supplement Information






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