DESCRIPTION

Scleroderma is a chronic autoimmune disease that involves the thickening and hardening of the skin and connective tissue and is considered a type of arthritis disorder. It can also affect joints, blood vessels and internal organs. Autoimmune diseases are illnesses which occur when the body's tissues are attacked by its own immune system. Scleroderma is characterized by the formation of scar tissue (fibrosis) in the skin and organs of the body. This leads to thickness and firmness of involved areas.

Scleroderma is derived from the Greek words skleros (hard or indurated) and derma (skin). Hippocrates first described this condition as thickened skin. Carlo Curzio (1752) offered the first detailed description of scleroderma in a patient with hard skin, which he described as wood-like or as containing a dry hide. In 1836, Giovambattista Fantonetti applied the term scleroderma to a patient's condition. He applied the term to describe a patient with dark leather-like skin who exhibited a loss of range of joint motion due to skin tightening. Robert H. Goetz first described in detail the concept of scleroderma as a systemic disease in 1945; he introduced the term progressive systemic sclerosis to emphasize the systemic and often progressive nature of the disease.

There are two types, localized and systemic. In the localized type, the skin shows one or more patches of sclerosis (thickening and hardening). Scleroderma, when it's diffuse or widespread over the body, is referred to as systemic sclerosis involving the skin and the connective tissue.

Systemic forms of scleroderma include progressive systemic sclerosis (PSS), also known as systemic sclerosis (SS), and the CREST syndrome. Systemic scleroderma involves body systems such as the esophagus, intestines, lungs, heart and kidneys.

Diffuse scleroderma is a term which describes systemic sclerosis and skin changes on many parts of the body. Tight, glossy skin may be present on the trunk and upper arms as well as on the face, chest and extremities.

The CREST syndrome is an acronym made up of the first letters of the five most prominent manifestations of this form of scleroderma. They are: calcinosis (accumulation of calcium salts under the skin), Raynaud's phenomenon, esophageal dysfunction, sclerodactyly and telangiectasia.

Systemic scleroderma can occur in both men and women, and it typically affects women in their thirties and forties. Each case is different, and the severity of the disease varies among patients.

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SIGNS & SYMPTOMS OF SCLERODERMA

The symptoms of scleroderma depend on the type of scleroderma present and the extent of external and internal involvement in the individual affected. Because scleroderma can affect the skin, esophagus, blood vessels, kidneys, lungs, blood pressure and bowels, the symptoms it causes can involve many areas of the body.

Scleroderma affects the skin to cause local or widespread signs of inflammation (redness, swelling, tenderness, itching, and pain) that can lead to skin tightness or hardening. These skin changes can be widespread, but it's most common for them to affect the fingers, feet, face, and neck. This can lead to decreased range of motion of the fingers, toes, and jaw. Tiny areas of calcification (calcinosis), while not common, can sometimes be noticed as hard nodules at the tips of the elbows or in the fingers.

Scleroderma affecting the esophagus leads to heartburn. This is directly a result of stomach acid flowing back up into the esophagus. Sometimes this can lead to scarring of the esophagus with difficulty swallowing and/or localized pain in the central chest.

Blood vessels that can be affected include the tiny arterioles of the finger tips, toes, and elsewhere. These vessels can have a tendency to spasm when the areas are exposed to cold, leading to blueness, whiteness, and redness of involved fingers, toes, and sometimes nose or ears. These color changes are referred to as Raynaud's phenomenon. Raynaud's phenomenon can cause inadequate supply of oxygen to the involve tips of fingers or toes, causing tiny ulcers or blackened (dead) skin. Sometimes Raynaud's phenomenon is also associated with tingling. Other blood vessels that can be involved in scleroderma are the tiny capillaries of the face, lips, mouth, or fingers. These capillaries widen (dilate) forming tiny, red blanching spots, called telangiectasias.

MoonDragon's Health & Wellness: Raynaud's Disease & Phenomenon

Elevated blood pressure is potentially serious and can lead to kidney damage. Symptoms include headache, fatigue, and in severe cases, stroke.

MoonDragon's Health & Wellness: Hypertension

MoonDragon's Health & Wellness: Stroke

MoonDragon's Health & Wellness: Kidney Disorders

Inflammation of the lungs in scleroderma can cause scarring, resulting in shortness of breath, especially with physical exertion. Elevated pressure in the arteries to the lungs (pulmonary hypertension) can also cause shortness of breath and difficulty getting an adequate breath with activity.

Scleroderma affecting the large bowel (colon) most often causes constipation but can also lead to cramping and diarrhea. When this is severe, it complete stool blockage (fecal impaction) can result.

MoonDragon's ObGyn Information: Constipation

MoonDragon's Health & Wellness: Diarrhea

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CAUSE

The cause of scleroderma is not known. Researchers have found some evidence that genetics may play an important role, but the environment seems to also be a factor. The result is activation of the immune system, causing injury to tissues that result in injury similar to scar tissue formation. The fact that genes seem to cause a predisposition to developing scleroderma means that inheritance at least plays a partial role. It is not unusual to find other autoimmune diseases in families of scleroderma patients. Some evidence for the role genes may play in leading to the development of scleroderma comes from the study of Choctaw Native Americans who are the group with the highest reported prevalence of the disease. The disease is more frequent in females than in males.

The exact etiology of systemic sclerosis is unclear; however, the following pathogenic mechanisms are always present: Endothelial cell injury. Fibroblast activation. Cellular and humoral immunologic derangement. Environmental factors (eg, triggers or accelerators) for the development of systemic sclerosis include the following: Silica exposure. Solvent exposure (vinyl chloride, trichloroethylene, epoxy resins, benzene, carbon tetrachloride). Radiation exposure or radiotherapy. Cytomegalovirus, human herpes-virus-5, and parvovirus-B19 have been proposed as viral accelerating factors, but evidence of their involvement is inconclusive. Drugs: Bleomycin and pentazocine may be involved in the development of systemic sclerosis.

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SCLERODERMA CLASSIFICATION

Scleroderma can be classified in terms of the degree and location of the skin involvement. Accordingly, scleroderma has been categorized into two major groups, diffuse and limited.

The diffuse form of scleroderma (systemic sclerosis) involves symmetric thickening of skin of the extremities, face, and trunk (chest, back, abdomen, or flanks) which can rapidly progress to hardening after an early inflammatory phase. Organ disease can occur early on and be serious. Organs affected include the esophagus, bowels, lungs with scarring (fibrosis), heart, and kidneys. High blood pressure can be a troublesome side effect.

The limited form of scleroderma tends to be confined to the skin of the fingers and face. The skin changes and other features of disease tend to occur more slowly than in the diffuse form. Because a characteristic clinical pattern can occur in patients with the limited form of scleroderma, this form has taken another name which is composed of the first initials of the common components. Thus, this form is also called the CREST variant of scleroderma. This name represents the following features:

C - Calcinosis refers to the formation of tiny deposits of calcium in the skin. This is seen as hard whitish areas in the superficial skin, commonly overlying the elbows, knees, or fingers. These firm deposits can be tender, can become infected, and can fall off spontaneously or require surgical removal. This is the least common of the CREST scleroderma variant features.

R - Raynaud's phenomenon refers to the spasm of the tiny artery vessels supplying blood to the fingers, toes, nose, tongue, or ears. These areas turns blue, white, then red after exposure to extremes of cold, or even sometimes with extremes of heat or emotional upset.

E - Esophagus disease in scleroderma is characterized by poorly functioning muscle of the lower two-thirds of the esophagus. This can lead to an abnormally wide esophagus which allows stomach acid to back-flow into the esophagus to cause heartburn, inflammation, and potentially scarring. This can eventually lead to difficulty in passing food from the mouth through the esophagus into the stomach. Symptoms of heartburn are treated aggressively in patients with scleroderma in order to prevent injury to the esophagus.

S - Sclerodactyly refers to the localized thickening and tightness of the skin of the fingers or toes. This can give them a "shiny" and slightly puffy appearance. The tightness can cause severe limitation of motion of the fingers and toes. These skin changes generally progress much slower that those of patients with the diffuse form of scleroderma.

T - Telangiectasias are tiny red areas, frequently on the face, hands and in the mouth behind the lips. These areas blanch when they are pressed upon and represent dilated capillaries.

Patients can have variations of CREST, for example, CRST, REST, ST, etc. Patients can also have "overlap" illness with features of both CREST and the diffuse form of scleroderma. Some patients have overlaps of scleroderma and other connective tissue diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and polymyositis. When features of scleroderma are present along with features of polymyositis and systemic lupus erythematosus, the condition is referred to as mixed connective tissue disease (MCTD).

Finally, scleroderma skin changes can be very localized. Morphea is scleroderma skin that is localized to a patchy area of the skin that becomes hardened and slightly pigmented. Sometimes morphea can cause multiple lesions in the skin. Morphea is not associated with disease elsewhere in the body. Linear scleroderma is scleroderma that is localized usually to a lower extremity, frequently presenting as a strip of hardening skin down the leg of a child. Linear scleroderma in children can stunt bone growth of the affected limb. Sometimes linear scleroderma is associated with a "satellite" area of a patch of localized scleroderma skin, such as on the abdomen.

ACR CLASSIFICATION CRITERIA The American College of Rheumatology (ACR) criteria for the classification of systemic sclerosis require one major criterion or two minor criteria, as follows: Major Criterion: Proximal scleroderma is characterized by symmetric thickening, tightening, and induration of the skin of the fingers and the skin that is proximal to the metacarpophalangeal or metatarsophalangeal joints. These changes may affect the entire extremity, face, neck, and trunk. Minor Criteria: Sclerodactyly is characterized by thickening, induration, and tightening of the skin, limited to only the fingers. Digital pitting scars or a loss of substance from the finger pad: As a result of ischemia, depressed areas of the fingertips or a loss of digital pad tissue occurs. Bibasilar pulmonary fibrosis includes a bilateral reticular pattern of linear or lineonodular densities most pronounced in basilar portions of the lungs on standard chest roentgenography. These densities may assume the appearance of diffuse mottling or a honeycomb lung and are not attributable to primary lung disease. Systemic sclerosis is a systemic disease that affects many organ systems. It is most obvious in the skin; however, the GI tract; the respiratory, renal, cardiovascular, and genitourinary systems; and numerous vascular structures are frequently involved. The symptoms result from inflammation and progressive tissue fibrosis and occlusion of the microvasculature by excessive production and deposition of types I and III collagens. The levels of other macromolecules (eg, glycosaminoglycans, tenascin, fibronectin) found in the connective tissue are also increased. The vascular alterations show a predilection for the small arteries and arterioles. Vascular dysfunction is one of the earliest alterations of systemic sclerosis and may represent the initiating event in its pathogenesis. Severe alterations in small blood vessels of skin and internal organs, including fibrosis and perivascular cellular infiltration with activated T cells, are almost always present in systemic sclerosis. INCIDENCE FREQUENCY United States: The estimated incidence of systemic sclerosis is 19 cases per million population, and the prevalence of systemic sclerosis has been estimated at 240 cases per million population, although the reported prevalence has ranged from 138 to 286 cases per million population. The prevalence has increased because of earlier detection through better diagnosis and an increased survival rate. Obtaining an exact estimate of prevalence is difficult because systemic sclerosis is frequently misdiagnosed. Juvenile-onset systemic sclerosis is uncommon and usually presents as an overlap syndrome with myositis. In the United States, the prevalence of systemic sclerosis has been reported to be as high as 400 cases per million women aged 35-65 years. International: Systemic sclerosis is found worldwide. MORBIDITY & MORTALITY Pulmonary hypertension and scleroderma renal crisis are the most frequent causes of mortality. Survival averages 12 years from diagnosis and correlates best with the clinical disease subtype (diffuse cutaneous vs limited cutaneous) and extent of organ involvement. The limited cutaneous subset carries a 10-year survival rate of 71 percent. The diffuse cutaneous subset carries a 10-year survival rate of 21 percent. Pulmonary hypertension is a major prognostic factor for survival. RACE Systemic sclerosis affects individuals of all races. The risk of systemic sclerosis in blacks is slightly higher than in whites; in young black women, the risk is 10 times higher. Incidence rates among ethnically related groups who are geographically separate show some discrepancy. The incidence of systemic sclerosis is lower in native Nigerians than in African Americans. Oklahoma Choctaw Indians have an incidence of 472 cases per million population, which is higher than that of the Missouri Choctaw Indians. These differences may be due to environmental exposures or differences in genetic predisposition. SEX The risk of systemic sclerosis is 3-9 times higher in women than in men. AGE The peak onset occurs in individuals aged 30-50 years.

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DIAGNOSIS

DIAGNOSTIC TESTS

The diagnosis of the scleroderma syndrome is based on the finding of the clinical features of the illnesses. Nearly all patients with scleroderma have blood tests which suggest autoimmunity, antinuclear antibodies (ANAs). A particular antibody, the anticentromere antibody, is found almost exclusively in the limited, or CREST, form of scleroderma. Anti-Scl 70 antibody (antitopoisomerase I antibody) is most often seen in patients with the diffuse form of scleroderma.

Other tests are used to evaluate the presence or extent of any internal disease. These may include upper and lower gastrointestinal tests to evaluate the bowels, chest x-rays, lung function testing, and CAT scanning to examine the lungs, EKG and echocardiograms, and sometimes heart catheterization to evaluate the pressure in the arteries of the heart and lungs.

CLINICAL - PATIENT HISTORY

Skin

• Diffuse pruritus.
• Skin tightness and induration.
• Skin pigmentary changes (hyperpigmentation or hypopigmentation).

Vascular System

• Raynaud's phenomenon (70 percent of patients with systemic sclerosis initially present with this symptom; 95 percent eventually develop it during the course of their disease).
• Healed pitting ulcers in fingertips.
• Cutaneous and mucosal telangiectasis.

Gastrointestinal System

• Gastroesophageal reflux caused by lower esophageal sphincter (LES) incompetence and decreased or absent peristalsis in the lower two thirds of the esophagus (may lead to hoarseness, aspiration pneumonia, and dysphagia).
• Dyspepsia, bloating, and early satiety.
• Constipation alternating with diarrhea (may lead to malabsorption).

Respiratory System

• Progressive dyspnea.
• Chest pain (precordial) due to pulmonary artery hypertension.
• Dry persistent cough due to restrictive lung disease.

Musculoskeletal System

• Arthralgia.
• Myalgia.
• Loss in joint range of motion.
• Symptoms of carpal tunnel syndrome.
• Muscle weakness.

Cardiovascular System

• Dyspnea due to pericardial effusion, congestive heart failure, or myocardial fibrosis.
• Palpitations, irregular heart beats, and syncope due to conduction abnormalities.
• Congestive heart failure.

Genitourinary System

• Erectile dysfunction.
• Dyspareunia (if introitus is affected).

Ears, Nose, & Throat

• Sicca syndrome.
• Poor dentition due to sicca syndrome.
• Loosening of dentition due to alteration in the tooth suspensory ligament and thickening of the periodontal membrane.
• Hoarseness due to acid reflux or vocal cord fibrosis.

Endocrine System

• Hypothyroidism.

Renal System

• Hypertension.
• Renal crisis.
• Chronic renal insufficiency.

Neurologic

• Facial pain and hand paresthesias due to sensory peripheral entrapment neuropathy.
• Headache and stroke during hypertensive renal crisis.

Constitutional

• Fatigue.
• Weight loss.

CLINICAL - PHYSICAL EXAMINATION

Skin

• Skin pigmentary changes include a salt-and-pepper appearance, with areas of hyperpigmentation alternating with hypopigmentation, or an overall appearance of tanned skin that persists long after sun exposure.



• Telangiectasias are dilated vessels located just beneath the dermis on any skin area, but they are most obvious in the face (perioral area), hands, and anterior chest.



• The skin of the hands may be edematous or swollen early in the disease, and the patient may initially report this as puffy changes. This edematous stage precedes the indurated sclerotic stage; longer time to progression to the sclerotic phase indicates a better prognosis. A rapid progression of sclerosis is associated with a worse prognosis and, often, more extensive and aggressive visceral organ involvement with an increased risk of renal crisis development.



• In the sclerotic phase, the skin may appear tight and shiny, with a characteristic loss of hair, decreased sweating, and loss of the ability to make a skin fold. This process of thickening generally begins distally on the fingers. Structures such as skin creases and dorsal veins begin to fade. The skin induration usually progresses proximally in a continuous symmetrical fashion.



• Calcinosis may develop on the fingers and extremities, usually the extensor side of the forearms and the prepatellar areas; however, any area can be affected.



• Limited cutaneous systemic sclerosis involves areas distal to the elbow and knee but may involve the face and neck. CREST (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias [not all are needed to be called CREST]) syndrome is an older term used to describe this subset of limited cutaneous systemic sclerosis.



• Diffuse cutaneous systemic sclerosis refers to skin thickening on the trunk and proximal aspects of the extremities in addition to the face.



• Reduced oral aperture (microstomia) due to perioral involvement (measure incisor-to-incisor distance) may develop.



• Edema may be the result of hydrophilic glycosaminoglycan deposits in the dermis. These changes (edema) may also reflect vascular changes, inflammation, and hydrostatic changes. The mechanism by which the edema resolves is not clear. Possibly, the edema becomes less apparent owing to a reduction of the hydrophilic glycosaminoglycan deposits as they are replaced by the less hydrophilic fibrous collagens. Alternatively, the edema does not resolve but becomes clinically less apparent because of dermal thickening. The edema usually does not improve with the use of diuretic therapy.

Eyes, Ears, Nose, & Throat

• Salivary production may be decreased and spontaneous sublingual pooling of saliva may be absent.



• Xerostomia and xerophthalmia may be part of the examination findings. A confirmatory minor salivary gland biopsy may show fibrosis without the pronounced lymphocytic aggregates that would be expected with primary Sjogren's syndrome. In addition, patients with systemic sclerosis typically do not harbor anti-Ro and anti-La antibodies.



• Oropharyngeal and esophageal cancers are more common in persons with diffuse systemic sclerosis.

Vascular Changes

• Raynaud phenomenon results in characteristic color changes of pallor, cyanosis, and then redness (white, blue, red), which are accompanied by numbness, tingling, or pain. These events may be triggered by cold, smoking, or emotional stress. Subintimal hyperplasia, typically present in systemic sclerosis vessels, can reduce the luminal diameter by more than 75 percent, limiting blood flow. This baseline reduction, in addition to the natural response to cold, accounts for the exaggerated response.



• Raynaud phenomenon occurs in 5-15 percent of the general population. The female-to-male ratio is 4:1, with onset occurring during the teenaged years.



• Raynaud phenomenon may precede obvious systemic sclerosis features by months or even years. Symptoms may last longer than 2 years. If this occurs without the development of characteristic connective-tissue diseases, a benign primary Raynaud phenomenon is generally indicated, with an excellent prognosis. However, 5-10 percent of this population may eventually develop systemic sclerosis.



• Infarction and dry gangrene may be due to severe vasospasm or to structural vascular occlusion. This process usually involves the digits but can also involve the lips, nose, and ears.



• Nail-fold capillary microscopy demonstrates fewer capillaries than normal (ie, capillary loop drop and numerous dilated capillary loops.

Musculoskeletal System

• Patients may present with generalized arthralgias and morning stiffness that may mimic other systemic autoimmune diseases. Clinically apparent synovitis is uncommon. Hand and joint function may decline over time because of skin tightening rather than arthropathy. Tendon friction rubs are found almost exclusively in diffuse systemic sclerosis and may be detected as the tendon is moved actively or passively.
  
  
• The following palpable tendon friction rubs may be found:
  • Shoulder - Scapula.
  • Elbow - Olecranon.
  • Knee - Patella.
  • Wrists - Flexor or extensor.
  • Fingers - Flexor or extensor (rare).
  • Ankle - Anterior tibia, posterior tibia, peroneal, Achilles.
• Myositis may cause weakness and muscle wasting. Levels of serum creatine kinase (CK) and aldolase are elevated.



• Acroosteolysis (ie, resorption or dissolution of the distal end of the phalanx) may occur.



• Flexion contractures of any affected joint may occur.

Respiratory System

• Dry rales may be the only physical examination finding that suggests pulmonary involvement in systemic sclerosis.
• An accentuated pulmonic secondary heart sound (P2) or right ventricular heave may indicate the presence of pulmonary artery hypertension.
• Transthoracic echocardiography is a non-invasive study for assessing pulmonary artery pressure. A systolic pulmonary artery pressure of greater than 35 mm Hg is considered to represent pulmonary artery hypertension. However, right-sided heart catheterization provides the most accurate pulmonary artery pressure.
• Pulmonary function testing is important in all patients with systemic sclerosis, although lung volumes can correlate poorly with extent of interstitial lung disease. Results of pulmonary function testing are ultimately abnormal in 80 percent of the patients. Carbon monoxide diffusion capacity (DLCO) is very sensitive and helps establish organ involvement at an earlier stage. Pulmonary function tests may demonstrate a decreased forced vital capacity and total lung capacity and a low DLCO. These changes reflect fibrotic infiltration in the lung. An isolated or disproportionate reduction of DLCO with a ratio of forced vital capacity (FVC) or total lung capacity (TLC) to DLCO of greater than 1.6 indicates pulmonary vascular fibrosis and vascular obliteration that leads to pulmonary hypertension.
• A high-resolution CT scan (HRCT) is highly sensitive for revealing pulmonary involvement. It may demonstrate a ground-glass appearance in areas of active alveolitis or septal fibrosis and honeycombing in areas of interstitial fibrosis. Patients with normal initial HRCT findings have a good long-term prognosis.
• Patients are at risk for aspiration pneumonia due to lower esophageal sphincter incompetence.

Gastrointestinal System

• Reflux due to decreased lower esophageal sphincter pressure.
• Severe esophagitis.
• Barrett metaplasia (can lead to cancer).
• Candida esophagitis.
• Esophageal strictures.
• Gastric vascular antral ectasia (dilated submucosal capillaries), also known as watermelon stomach.
• Primary biliary cirrhosis (PBC) associated with antimitochondrial antibodies (Studies have shown that liver dysfunction in patients with PBC and systemic sclerosis may progress more slowly than in patients with PBC alone.).
• Wide-mouth colonic diverticula.
• Malabsorption.
• Atrophy of smooth muscle and fibrotic changes leading to decreased peristalsis throughout the GI tract (gastroesophageal reflux disease [GERD], gastroparesis, constipation, pseudo-obstruction).
• Anal sphincter incompetence.

Renal System

• Patients with diffuse, rapid skin involvement have the highest risk (approximately 20-25 percent) of developing scleroderma renal crisis. Renal crisis occurs in about 10 percent of all patients with systemic sclerosis.
• Renal crisis presents as accelerated hypertension, oliguria, headache, dyspnea, edema, and rapidly rising serum creatinine levels.
• Approximately 10 percent of renal crisis cases occur in the absence of an elevated blood pressure.
• Renal crisis is observed within 4 years of diagnosis in about 75 percent of patients but may develop as late as 20 years after diagnosis. Renal crises are slightly more common in black than in whites, and men have a greater risk than women.
• Scleroderma renal crisis that is not treated aggressively invariably leads to renal failure, requiring dialysis or renal transplantation, or even death.
• Preventing renal crisis is critical. Check blood pressure, monitor serum creatinine, and start angiotensin-converting enzyme (ACE) inhibitors early in at-risk patients.
• Avoid high doses of corticosteroids since this is a significant risk factor for renal crisis.

Cardiovascular System

• Cardiac involvement indicates a worse prognosis. Pericardial effusion is usually asymptomatic and may develop in up to one third of patients with systemic sclerosis. Clinically significant pericarditis is rare.
• Cor pulmonale may develop secondary to long-standing pulmonary fibrosis or pulmonary artery hypertension.
• Conduction abnormalities, including complete A-V block, may be revealed with routine ECG or, more frequently, with 24-hour Holter monitor or echocardiography.
• Infiltrative cardiomyopathy with replacement of cardiac muscle by fibrous tissue can lead to arrhythmias, heart failure, or both.
• Contraction band necrosis results from global ischemia and reperfusion. Patients may have recurrent episodes of vasospasm that are caused by the same mechanism involved in Raynaud phenomenon. This process can lead to cardiomyopathy and heart failure.

Neurologic System

• Trigeminal neuralgia (uncommon) and carpal tunnel symptoms may result from peripheral entrapment neuropathies. Although rare, sensory neuropathies unrelated to entrapment may be present.

Obstetrics & Gynecology

• Women may experience vaginal dryness, dyspareunia, and menstrual irregularities.
• Pregnancy in women with systemic sclerosis is considered a high risk because of a higher risk of pregnancy loss and higher complication rates, but a diagnosis of systemic sclerosis is not an absolute contraindication for pregnancy. A study of 50 patients (67 pregnancies) showed that 18 percent miscarried, 26 percent delivered preterm, and 55 percent delivered at full term. Pregnancy risk is greatest in those who have had the disease for less than 4 years and who also have diffuse cutaneous involvement.
• Some symptoms may increase during pregnancy (eg, edema, arthralgias, GERD). Skin manifestations are not reported to worsen, but the data on this matter are incomplete. Raynaud symptoms may improve during pregnancy, only to worsen after delivery.
• Certain medications, such as D-penicillamine, cytotoxic agents, and ACE inhibitors, should be discontinued prior to pregnancy.

Genitourinary System

• Erectile dysfunction is common in males and is the presenting symptom in some cases.
• Urinary bladder infiltration may cause microhematuria.

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CONVENTIONAL MEDICAL TREATMENT

Treatment of scleroderma is directed toward the individual feature(s) affecting different areas of the body.

Aggressive treatment of elevations in blood pressure have been extremely important in prevent kidney failure. Blood-pressure medications, such as captopril, are frequently used.

Recent data indicate that colchicine can be helpful in decreasing the inflammation and tenderness that periodically accompanies the calcinosis nodules in the skin. Skin itching can be relieved with lotions (emollients) such as Eucerin and Lubriderm.

Mild Raynaud's phenomenon may require only hand warming and protection. Low-dose aspirin is often added to prevent tiny blood clots in the fingers, especially in patients with a history of fingertip ulcerations. Moderate Raynaud's phenomenon can be helped by medications that open up the arteries, such as nifedipine (Procardia, Adalat) and nicardipine (Cardene), or with topical nitroglycerin applied to the most affected digit (most effective on the sides of the digit where the arteries are). Gently applied finger splinting can protect tender tissues. A class of medications that is typically used for depression, called serotonin reuptake inhibitors, such as fluoxetine (Prozac), can sometimes improve the circulation of the affected digit. Severe Raynaud's phenomenon can require surgical procedures, such as those to interrupt the nerves of the finger that stimulate constriction of the blood vessels (digital sympathectomy). Ulcerations of the fingers can require topical or oral antibiotics.

Esophagus irritation and heartburn can be relieved with omeprazole (Prilosec), esomeprazole (Nexium), or lansoprazole (Prevacid). Antacids can also be helpful. Elevating the head of the bed can reduce the back-flow of acid into the esophagus that causes inflammation and heartburn. Avoiding caffeine and cigarette smoking also helps.

Constipation, cramping, and diarrhea is sometimes caused by bacteria that can be treated with tetracycline or erythromycin. Recent studies have shown that erythromycin could also be used. Increased fluid intake and fiber intake are good general measures.

Irritated, itchy dry skin can be helped by emollients such as Lubriderm, Eucerin, or Bagbalm.

Telangiectasias, such as those on the face, can be treated with local laser therapy. Sun exposure should be minimized as it can worsen telangiectasias.

Approximately 10 percent of patients with the CREST variant develop elevated pressures in the blood vessels to the lungs (pulmonary hypertension). Abnormally elevated blood pressure of the arteries supplying the lungs is often treated with calcium antagonist medications, such as nifedipine, and blood-thinning drugs (anticoagulation). More severe pulmonary hypertension can be helped by continuous intravenous infusion of prostacyclin (Iloprost). A new drug taken by mouth, bosentan (Tracleer), is now available to treat severe pulmonary hypertension.

Additionally, medications are used to suppress the overly active immune system that seems to be spontaneously causing the disease in organs affected. Medications used for this purpose include penicillamine, azathioprine, and methotrexate. (Recent research has found that low-dose penicillamine [Depen, Cuprimine] [125 mg every other day] is as effective as previously used high doses of penicillamine, with less toxicity.) Serious inflammation of the lungs (alveolitis) can require immune suppression with cyclophosphamide (Cytoxan) along with prednisone. The optimal treatment of scleroderma lung disease is an area of active research. Stem-cell transplantation is being explored as a possible option.

No medication has been found to be universally effective for all patients with scleroderma. In an individual patient, the illness may be mild and not require treatments. In some, the disease is ravaging and relentless.

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PROGNOSIS

A patient's prognosis is optimized with close monitoring of overall health status and treatment of complications, especially elevated blood pressure. Recent data indicates that the critical period of organ risk is generally within the first three years of skin involvement. This means that patients can be reassured that their risk of organ-threatening complications is significantly less after three years of having skin symptoms.

Much more research is needed in all areas of scleroderma disease, from cause to treatment. Today scleroderma continues to baffle medical scientists. Researchers are evaluating the effectiveness of thalidomide for the treatment of scleroderma. More sensitive tests to detect early lung disease of scleroderma are also being evaluated. Psoralen and ultraviolet light therapy (PUVA) is being studied as a possible treatment for limited scleroderma.

Many researchers are investigating the roles of various cell messengers, called cytokines, in causing scleroderma. Researchers are also currently studying a hormone of pregnancy, called relaxin, for the treatment of scleroderma. Preliminary results suggest that it may improve scleroderma. Relaxin normally loosens the ligaments of the pelvis and ripens the womb for childbirth. How it might work in scleroderma is unclear.

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POSSIBLE LIFESTYLE CHANGES FOR SCLERODERMA

Avoid extreme changes in temperature, especially going from warm to cold.

Eat a healthful diet to minimize gastrointestinal discomfort.

Maintain a regular exercise program to improve circulation and maximize flexibility.

Join a support group to reduce stress and learn effective ways to living with the disease.

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BENEFICIAL DIETARY SUPPLEMENTS

Evening Primrose Oil and Flax Seed Oil have anti-inflammatory properties.

Mountain Rose Herbs: Evening Primrose Seed Oil Bulk Oil, Certified Organic, 4 oz to 5 gallons

Herbal Remedies: Barlean's Primrose Oil, With Gamma Linolenic Acid (GLA), 1300 mg, 120 SoftGels

Herbal Remedies: Barlean's Flax Oil, 100% Highest Lignan Content, Organic, Pesticide & Herbicide Free, 16 fl. oz.

Herbal Remedies: Barlean's Flax Oil, Highest Lignan, 1000 mg, 250 Caps

Vitamin E helps prevent tissue hardening.

Herbal Remedies: Ester E Natural Vitamin E, California Natural, 400 IU, 60 Softgels

Herbal Remedies: Vitamin E, 400 IU, 100% Natural, NOW Foods, 100 Gels

Herbal Remedies: Vitamin E-1000, NOW Foods, 1000 IU, 100 Gels

Herbal Remedies: Vitamin E, d-alpha-tocopherol, 400 IU, 100 Softgels

Calcium helps strengthen bones, which can deteriorate with scleroderma.

Herbal Remedies: Calcium Ionic Mineral Supplement, Fully Absorbable, 700 +/- ppm, 16 fl. oz.

Herbal Remedies: Liquid Calcium W/ConcenTrace, Orange Vanilla, Trace Minerals, 1000 mg, 32 fl. oz.

Herbal Remedies: Cal-Mag Pre-Chelated Calcium & Magnesium, Vital Earth, 240 Gelcaps

Herbal Remedies: Just An Ounce Calcium & Magnesium Liquid, Almond Flavor, 16 fl. oz.

Herbal Remedies: Calcium & Magnesium Mineral Complex, 100% Natural, Nature's Way, 500 mg / 250 mg, 250 Caps

Vitamin C with Bioflavonoids is necessary for healthy connective tissues.

Herbal Remedies: Vitamin C Liquid w/ Rose Hips & Bioflavonoids, Kosher, Natural Citrus Flavor, Dynamic Health, 1000 mg, 16 fl. oz.

Herbal Remedies: Ester C With Bioflavonoids, Nature's Way, 1000 mg, 90 Tabs

Herbal Remedies: Vitamin C 1000 With Bioflavonoids, Nature's Way, 100% Natural, 1000 mg, 250 VCaps

Herbal Remedies: The Right C, Nature's Way, 1000 mg, 120 Tabs

The extract of the Devil's Claw Root, Comfrey, Sassafras and Licorice help aid skin conditions.

Mountain Rose Herbs: Devil's Claw Root, Certified Organic, 4 oz, 8 oz, or 16 oz. Bulk

Herbal Remedies: Devil's Claw Extract, Standardized, Nature's Way, 480 mg, 90 Caps

Herbal Remedies: Devil's Claw Tincture, 100% Organic, 2 fl. oz.

Herbal Remedies: Devil's Claw Root, Nature's Way, 480 mg, 100 Caps

Mountain Rose Herbs: Comfrey, Certified Organic, 4 oz, 8 oz, or 16 oz. Bulk

Herbal Remedies: Comfrey Extract Tincture, Herbal Remedies USA, 2 fl. oz.

Herbal Remedies: Comfrey Leaf / Herb Skin Poultice, 2.5 oz.

Herbal Remedies: Comfrey Leaf Powder, 4 oz. Bulk

Herbal Remedies: Comfrey Leaf Ointment, Nature's Way, 2 oz.

Mountain Rose Herbs: Sassafras, Certified Organic, 4 oz, 8 oz, or 16 oz. Bulk

Herbal Remedies: Acne & Skin Disorders Formula Tincture, 2 fl. oz.

Mountain Rose Herbs: Licorice Root, Certified Organic, 4 oz, 8 oz, or 16 oz. Bulk

Herbal Remedies: Licorice Root Powder, 4 oz. Bulk

Herbal Remedies: Egyptian Licorice Tea, Certified Organic, Yogi Tea, 16 Tea Bags

Herbal Remedies: Licorice Extract Tincture, Herbal Remedies USA, 2 fl. oz.

Herbal Remedies: DGL, NOW Foods, 400 mg, 100 Lozenges

Horsetail Extract helps rebuild connective tissue.

Mountain Rose Herbs: Horsetail, Certified Organic, 4 oz, 8 oz, or 16 oz. Bulk

Herbal Remedies: Horsetail Supplement Tincture, 2 fl. oz.

Herbal Remedies: Horsetail Herb Grass, Nature's Way, 440 mg, 100 Caps

Herbal Remedies: Silica Complex Supplement, 8% Extract, NOW Foods, 500 mg, 90 Tabs

Gotu Kola helps improve skin conditions.

Mountain Rose Herbs: Gotu Kola, Certified Organic, 4 oz, 8 oz, or 16 oz. Bulk

Herbal Remedies: Gotu Kola Powder, 4 oz. Bulk

Herbal Remedies: Gotu Kola Tincture, 100% Organic, 2 fl. oz.

Herbal Remedies: Gotu Kola, Nature's Way, 475 mg, 180 Caps

Beta-carotene is helpful in treating skin disorders.

Herbal Remedies: Multi-Carotene Antioxidant Supplement, Nature's Way, 60 Softgels

Herbal Remedies: Beta Carotene (Dry Natural), 100% Natural Dunaliella Salina, Nature's Way, 25,000 IU, 100 Caps

Herbal Remedies: Beta Carotene, Natural Dunaliella Salina, Nature's Way, 25,000 IU, 100 SoftGels

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SCLERODERMA SUPPLEMENTS

Information, supplements and products for scleroderma.

Beta Carotene, 100% Natural, Nature's Way, 25,000 IU, 100 Softgels Nature's Way beta carotene is 100% all natural from Dunaliella Salina.

Comfrey Leaf Ointment, Nature's Way, 2 oz. Comfrey Leaf Ointment is a 100% all natural, mild scented, herbal ointment.

Gotu Kola, Nature's Way, 475 mg, 180 Caps Gotu Kola (Centella asiatica) is used in India similar to how the Chinese use Ginseng, for longevity and vitality. Although its name is similar to cola nut, Gotu Kola does not contain caffeine.

Just An Ounce Calcium & Magnesium Liquid, Almond Flavor, 16 fl. oz. Just An Ounce, Calcium and Magnesium Liquid can help with the development of strong bones and teeth, also prevents muscle cramping, risk of colon cancer, maintain regular heart beat, protects against osteoporosis and helps relax the central nervous system.

Vitamin C 1000 With Bioflavonoids, Nature's Way, 100% Natural, 1000 mg, 250 Vcaps Nature's Way Vitamin C with bioflavonoids provides antioxidant protection for many of the body's important enzyme systems.

Vitamin E, D-Alpha Tocopherol, 400 IU, 100 Softgels Vitamin E has potent antioxidant activity, supplies oxygen to the blood, aids in strengthening capillary walls, and plays a beneficial role in cancer and cardiovascular disease prevention, anti-aging benefits, circulation, wound-healing, immune function, nervous system function, PMS, hot flushes, diabetes, vascular disease, eye health, tissue repair, athletic performance, leg cramps, skin and hair health, and alleviating fatigue.

Herbal Remedies: Scleroderma Information

Herbal Remedies: Scleroderma Supplements & Products

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NUTRITIONAL SUPPLEMENT RECOMMENDATIONS FOR RAYNAUD'S


The following nutrients are important for healing once appropriate local treatment has been administered. Unless otherwise specified, the following recommended doses are for those over the age of 18. For a child between 12 and 17 years old, reduce the dose to 3/4 the recommended amount. For a child between 6 and 12 years old, use 1/2 the recommended dose, and for a child under 6, use 1/4 the recommended amount.

NUTRIENTS
Supplement	Suggested Dosage	Comments
Essential
Coenzyme Q-10	100 mg twice daily.	Powerful antioxidants that help to improve circulation and boost the immune system. CoQ10, Vegetarian Coenzyme, NOW Foods, 30 mg, 60 VCaps, CoQ10, Now Foods, 400 mg, 60 Softgels
Coenzyme A	As directed on label.	Powerful antioxidants that help to improve circulation and can streamline metabolism, increase energy, support adrenal glands, process fats, remove toxins from the body, boost the immune system, and improve overall physical and mental processes. Pantethine (Coenzyme A Precursor), Highly Active Form of Vitamin B-5, 300 mg, NOW Foods, 60 Softgels
Vitamin E	Start with 200 IU daily and increase slowly, adding 100 IU each week until the dosage is 800-1,000 IU daily. Consult your health care provider if you are taking anticoagulant medication.	Strengthens the immune system and improves circulation, and destroys free radicals. Use d-alpha-tocopherol form. Ester E Natural Vitamin E, California Natural, 400 IU, 60 Softgels, Vitamin E, 400 IU, 100% Natural, NOW Foods, 100 Gels, Vitamin E-1000, NOW Foods, 1000 IU, 100 Gels, Vitamin E, d-alpha-tocopherol, 400 IU, 100 Softgels
Very Important
Calcium	1,500 mg daily, at bedtime.	To protect the arteries from stress caused by sudden blood pressure changes. For connective tissue repair. Dilates blood vessels, improving blood flow. Calcium Ionic Mineral Supplement, Fully Absorbable, 700 +/- ppm, 16 fl. oz., Liquid Calcium W/ConcenTrace, Orange Vanilla, Trace Minerals, 1000 mg, 32 fl. oz., Cal-Mag Pre-Chelated Calcium & Magnesium, Vital Earth, 240 Gelcaps
Magnesium	750 mg daily.	Needed to balance calcium and to help protect arteries from stress caused by sudden blood pressure changes. Connected to over 300 enzyme actions controlling glucose, proteins, and fats. Magnesium Ionic Mineral Supplement, Fully Absorbable, 350 +/- ppm, 16 fl. oz., Just An Ounce Calcium & Magnesium Liquid, Almond Flavor, 16 fl. oz., Calcium & Magnesium Mineral Complex, 100% Natural, Nature's Way, 500 mg / 250 mg, 250 Caps
Chlorophyll	As directed on label.	A blood cleanser. A source of minerals, enzymes, and vitamins. Also used as a blood detoxifier and nutrient. Helps to fight infection and enhance blood flow. Chlorofresh Liquid Chlorophyll, Mint Flavor, Nature's Way, 16 fl. oz. Chlorofresh Liquid, Natural, Nature's Way, 16 fl. oz., Barlean's Greens Superfood Supplement, 9.3 oz., Chlorella Green Algae, Nature's Way, 410 mg, 100 Caps, Chlorella Powder, NOW Foods, 100% Pure, 4 oz.
"Green Drinks" Fresh Wheatgrass Juice Such as Kyo-Green from Wakunaga	As directed on label.	Concentrated barley and wheatgrass juice; contains nutrients needed for healing. Acts as a blood cleanser and builds up the blood supply. Use liquid or tablet form. Also prepare fresh "green drinks" from leafy greens that supply chlorophyll and other nutrients. Wheat Grass Powder, Single Serving Packets, 15 Packets, Wheat Grass, Organic, 1000 mg, 200 Tabs, Wheat Grass Powder, Organic, 10 oz., Kamut Wheat Grass (Medicago Sativa) Powder, 4 oz. Bulk, ProGreens Powder With Advanced Probiotic, Allergy Research Group / Nutricology, 9.3 oz., Ultimate Green Superfood Supplement, Nature's Secret, 300 Tabs,
Choline And Inositol	As directed on label.	Improves tissue oxygenation and enhances oxygen utilization by affected tissue. Choline & Inositol, 100% Natural, Nature's Way, 250 mg, 250 mg, 100 Caps, Choline Supplement, 100% Natural, Nature's Way, 500 mg, 100 Tabs, Inositol (Vitamin B-8), 100% Natural, Pure Crystalline, Nature's Way, 500 mg, 100 Caps
Dimethylglycine (DMG)	1 tablet 3 times daily.	Improves tissue oxygenation and enhances oxygen utilization by affected tissue. DMG Supplement N,N Dimethyl Glycine, NOW Foods, 125 mg, 100 Caps
Garlic (Kyolic)	Fresh: 2-3 cloves. with meals 3 times daily. Fresh garlic can be added to vegetable drinks and juices and taken in liquid form. As directed on label.	Speeds healing and increases circulation. Cleanses the blood. Use the liquid form of Kyolic. Garlic Oil Tincture, Alcohol Free, Nature's Way, 1 fl. oz., Garlic Bulb Cloves, Garlic Supplement, Nature's Way, 580 mg, 100 Caps, Odorless Garlic Supplement, NOW Foods, 50 mg, 250 SoftGels, Garlic Supplement, Kwai, Triple Concentrated, 180 Tabs, Every Day Garlic Supplement, Kwai, 30 Tabs, Garlic Tincture, 100% Organic, 2 fl. oz., Aged Garlic Extract, Cardiovascular Formula 100, Wakunaga Kyolic Supplements, 300 Caps, Kyolic Liquid Aged Garlic Extract, Cardiovascular, Vegetarian, Wakunaga Kyolic, 4 fl. oz., Kyolic Aged Garlic Extract, One-A-Day, Vegetarian, 1000 mg, Wakunaga Kyolic, 30 Caps, Aged Garlic Extract, Cholesterol Formula 104, Wakunaga Kyolic, 200 Caps
Methylsulfonylmethane (MSM)	As directed on label.	Aids in the healing of injuries and can help to detoxify the body on a cellular level. It has also been found to be an aid to the organs, connective tissue, and immune functions. MSM Supplement (Methylsulfonylmethane), Pure Lignisul, 1000 mg, 120 Caps With Free 4 oz. Lotion, MSM Supplement (Methylsulfonylmethane) Liquid, Pure Lignisul, 16 fl. oz., MSM Supplement (Methylsulfonylmethane) Lotion, 15%, 8 fl. oz., MSM Supplement (Methylsulfonylmethane) Powder, Pure Lignisul, 4 oz., MSM Supplement (Methylsulfonylmethane) Cream, 2 oz.
Lecithin	Granules: 1 Tablespoon 3 times daily, with meals. Capsules: 1,200 mg 3 times daily, with meals.	For cellular protection. Lowers blood lipid levels. Lecithin Vegetarian Granules, 97% Phosphatides, Pure & Fresh, NOW Foods, 1 lb., Lecithin Vegetarian Granules, 97% Phosphatides, Identity Preserved, Non GE, NOW Foods, 1 lb., Liquid Lecithin, Vegetarian, NOW Foods, 16 fl. oz., Lecithin, Fine Vegetarian Granules, 97% Phosphatides, Pure & Fresh, NOW Foods, 1 lb., Lecithin Concentrate, Nature's Way, 400 mg, 100 Softgels, Lecithin Supplement, Nature's Way, 1200 mg, 100 Softgels
Vitamin B Complex	100 mg of each major B vitamin daily (amounts of individual vitamins in a complex will vary).	Necessary for all cellular functions. Anti-stress vitamins. B Vitamins necessary for metabolism of fat and cholesterol. Use a high potency formula. Ultimate B (Vitamin B Complex), Nature's Secret, 60 Tabs, Vitamin B-100 Complex, w/ Coenzyme B-2, Nature's Way, 631 mg, 100 Caps
Plus Extra Vitamin B-6 (Pyridoxine)	50 mg daily.	B Vitamins necessary for all cellular functions and metabolism. Enhances the efficacy of zinc. Vitamin B-6 (Pyridoxine), Nature's Way, 100 mg, 100 Caps
And Folic Acid (Vitamin B-9)	400 mcg daily.	B Vitamins necessary for all cellular functions and metabolism. Vitamin B-9 (Folic Acid), 100% Natural, Nature's Way, 800 mcg, 100 Caps
Plus Extra Vitamin B-3 (Niacin or Niacinamide)	100 mg daily. Do not exceed this amount of niacin. Niacinamide is safer at higher doses than niacin.	Dilates small arteries, improving circulation. Caution: Do not take niacin if you have a liver disorder, gout, or high blood pressure. Niacin Supplement (Vitamin B-3), 100% Natural, Nature's Way, 100 mg, 100 Caps, Niacinamide, Non-Flushing Niacin (Vitamin B-3), 100% Natural, Nature's Way, 500 mg, 100 Caps, Flush Free Niacin (Vitamin B-3), NOW Foods, 250 mg, 90 VCaps
Plus Vitamin C With Bioflavonoids	5,000-20,000 mg daily. See Ascorbic Acid Flush for more information.	For tissue repair and improved circulation. Improves the benefits of MSM. Vitamin C Liquid w/ Rose Hips & Bioflavonoids, Kosher, Natural Citrus Flavor, Dynamic Health, 1000 mg, 16 fl. oz., Ester C With Bioflavonoids, Nature's Way, 1000 mg, 90 Tabs, Vitamin C 1000 With Bioflavonoids, Nature's Way, 100% Natural, 1000 mg, 250 VCaps, The Right C, Nature's Way, 1000 mg, 120 Tabs
silicon	As directed on label.	Needed for skin and tissue repair. Silica Complex Supplement, 8% Extract, NOW Foods, 500 mg, 90 Tabs, Cellfood Silica Liquid Drops, Cellfood, 4 fl. oz., Original Silica Gel Supplement, Nature's Way, Vegetarian, 90 VCaps, Horsetail Herb Grass, Nature's Way, 440 mg, 100 Caps,
AE Mulsion Forte (Biotics)	As directed on label, to supply 50,000 IU vitamin A and 400-1,600 IU vitamin E daily. If you are pregnant, do not exceed 10,000 IU vitamin A daily.	Vitamin A is essential for tissue repair; vitamin E improves circulation. Both enhance immune function. Use this emulsion form for easier assimilation and safety at higher doses.
Important
Aerobic 07 (Aerobic Life Industries)	As directed on label. Also apply a few drops directly on the affected area.	A stabilized oxygen product. Kills infecting bacteria. Oxy Boost, Peter Gillham's Natural Vitality, 2 oz., Oxy Boost Plus, Therapeutic Strength, Peter Gillham's Natural Vitality, 2 oz., Stabilized Oxygen OxyDrops, Liquid Electrolytes, Sodium Chloride Solution, 4 fl. oz.,
Bee Propolis Or Royal Jelly	As directed on label. As directed on label.	To strengthen the cardiovascular system and act as a natural antibiotic. Bee Propolis Extract, NOW Foods, 500 mg, 100 Caps, Bee Propolis, Lemon Honey Flavor, Made in New Zealand, 12 High Potency Lozenges, Bee Propolis, Original Flavor, Made in New Zealand, 12 High Potency Lozenges, Supreme Beijing Royal Jelly With Bee Pollen, 10 ml Vials, 30 Vials, Propolis & Tea Tree Ointment (External Use For Tissue Repair), 3.53 oz.
Essential Fatty Acids (Flaxseed Oil, Primrose Oil, and Salmon Oil are all good sources.)	As directed on label.	To supply essential fatty acids, which are necessary for circulation and help prevent hardening of the arteries. Protects and aids in the repair of new tissues and cells. Ultimate Oil, Essential Fatty Acids Supplement, Nature's Secret, 90 SoftGels, Barlean's Flax Oil, 100% Highest Lignan Content, Organic, Pesticide & Herbicide Free, 16 fl. oz., Barlean's Flax Oil, Highest Lignan, 1000 mg, 250 Caps, Barlean's Primrose Oil, With Gamma Linolenic Acid (GLA), 1300 mg, 120 SoftGels, Wild Salmon Oil, 2000 mg, 120 EPA/ 80 DHA, NOW Foods, 250 SoftGels
Kelp	1,000-1,500 mg daily with meals.	A rich source of chlorophyll, important vitamins, minerals, and trace elements. Good for circulation. A blood cleanser. Kelp Supplement, Nature's Way, Certified, 650 mg, 100 Caps, Kelp Seaweed, Norwegian, NOW Foods, 100% Natural, 550 mg, 250 Caps, Kelp Seaweed, Norwegian Powder, 4 oz. Bulk
Beta-1,3-Glucan	As directed on label.	Helps to recruit immune T-Cells to the site of infection and aids in the growth of new blood vessels.
Multi-vitamin & Mineral Complex	As directed on label.	All nutrients are necessary for healing. Super Multi-Vitamin & Multi-Mineral, Pure Vital Earth, 32 fl. oz. (98% Bio-Available for Absorption), Damage Control Master Formula, High Potency, Multi-Vitamin & Mineral, 60 Packets (30 Day Supply)
Zinc	50-80 mg daily. Do not exceed a total of 100 mg daily from all supplements.	Speeds healing. Necessary for tissue repair and immune function. Use zinc gluconate lozenges or zinc methionate (OptiZinc) for best absorption. Zinc Ionic Mineral Supplement, Fully Absorbable, 100 +/- ppm, 16 fl. oz., Colloidal Silver & Zinc Lozenges, Silva Solution, 90 Lozenges, Zinc Lozenges W/ Echinacea & Vitamin C, Nature's Way, 23 mg, 60 Lozenges, Zinc (Chelated), 100% Natural, Nature's Way, 30 mg, 100 Caps

RAYNAUD'S DISEASE / RAYNAUD'S PHENOMENON SUPPLEMENTS & PRODUCTS

Information, supplements and products for Raynaud's Disease, a circulatory disorder that causes the fingers, toes and other extremities to be overly sensitive to cold. Also included are supplements and products helpful for treating infection and gangrene, which can result due to chronic vessel constriction and tissue damage.

Black Cohosh Extract, Standardized, Nature's Way, 40 mg, 120 VCaps Black Cohosh extract is the most popular herbal supplement in Europe for women experiencing change of life (peri-menopause) symptoms due to hormonal fluctuations.

Black Seed Theramune Ultimate With Garlic, 100 Caps Promotes healthy circulation, useful for arthritis and cardiovascular & respiratory support. It also supports digestion and is a natural remedy for ulcers. Garlic is known to lower cholesterol naturally.

Burdock Root (Arctium Lappa) Powder, 4 oz. Bulk Burdock Root is traditionally used for skin disorders associated with adolescence. It is also one of the most effective herbs for cleaning the blood without the side effect of nausea.

Butcher's Broom, 100% Organic, 2 fl. oz. Butcher's Broom is a laxative and diuretic and it is also used to improve circulation problems, hemorrhoids, varicose veins, arteriosclerosis, and blood clots.

Butcher's Broom Root, Nature's Way, 470 mg, 100 Caps Popular in Europe for improving circulation in the legs, Butcher's Broom Root contains a mixture of steroidal saponins which produce a vasoconstrictive effect.

Cayenne Pepper Supplement, Nature's Way, 450 mg, 180 Caps Cayenne Pepper Supplement is a blood warming herb that has an invigorating effect on several body systems.

Chlorofresh, Chlorophyll Supplement, Nature's Way, 50 mg, 90 Softgels Chlorofresh, Chlorophyll Supplement, is used chiefly as an aid to reduce odor from a colostomy or ileostomy and to reduce fecal odor due to incontinence.

Chlorofresh Liquid, Natural, Nature's Way, 16 fl. oz. Chlorofresh is a special liquid chlorophyll complex, derived from premium alfalfa leaves. Chlorofresh is used chiefly as an aid to reduce odor from a colostomy or ileostomy and to reduce fecal odor due to incontinence.

Choline & Inositol, 100% Natural, Nature's Way, 250 mg/250 mg, 100 Caps Nature's Way Choline Inositol is 100 percent natural crystalline inositol and choline bound to tartaric acid for superior absorption.

Comfrey Leaf Herb Skin Poultice, 2.5 oz. Comfrey leaf contains allantoin, which promotes the growth of connective tissue, bone, cartilage, and is easily absorbed through the skin.

Comfrey Leaf Powder, 100% Organic, 4 oz. Bulk One of the most well-known healing plants, especially for its ability to heal tissue and bone.

Coenzyme Q10: All-Around Nutrient for All-Around Health! Latest Research as a Heart Strengthener, Energy Promoter, Aging Fighter, and Much More. This Book discusses an amazing antioxidant that helps patients with heart failure, hypertension, coronary artery disease, high cholesterol levels and other diseases.

CoQ10, Vegetarian Coenzyme, NOW Foods, 30 mg, 60 VCaps A coenzyme for several key steps in the production of energy within each cell, and an antioxidant important in its clinical effects. It is these two properties make CoQ10 one of the best supplements available today.

CoQ10 With Vitamin E, NOW Foods, 200 mg, 90 Lozenges This new orange flavored chewable CoQ10 is formulated with 100 IU of Vitamin E in a base of non-genetically engineered Soy Lecithin.

DMG Supplement N,N Dimethyl Glycine, NOW Foods, 125 mg, 100 Caps NOW Foods DMG Supplement is a methylated amino acid found in all cells. DMG is an antioxidant and methyl donor that has a number of beneficial effects. It has shown to have potential in increasing immune response to the flu and salmonella.

Garlic Oil Tincture, Alcohol Free, Nature's Way, 1 fl. oz. Garlic oil is often used to soothe the ear and as an antibiotic but most often used as a food and herb and also to lower serum cholesterol and blood pressure and to improve circulation as well as possibly inhibiting the growth of ulcer causing bacteria.

Ginkgo Biloba Extract, Standardized, Nature's Way, 60 mg, 120 VCaps Nature's Way Ginkgo biloba extract is a technically and scientifically advanced herbal extract standardized to 24% Ginkgo flavone glycosides and 6% terpene lactones, supported by whole Gotu Kola herb.

Ginkgold, Ginkgo Biloba Extract, Standardized, Vegetarian, Nature's Way, 60 mg, 150 Tabs Nature's Way Ginkgold ginkgo biloba extract has been proven to support healthy circulation to the brain as well as the extremities.

Hawthorn Berry Tincture (Heart Herb), 100% Organic, 2 fl. oz. Throughout Europe, Hawthorn berry is recognized as a safe and effective treatment for the early stages of congestive heart failure (CHF).

Hydrogen Peroxide & Ozone By Conrad LeBeau Reveals documented details of the use of hydrogen peroxide as a successful treatment for many disorders, including arthritis, cancer, and AIDS.

Hyssop Herb, Nature's Way, 445 mg, 100 Caps Hyssop herb regulates blood pressure, purifies the blood & promotes circulation, excellent aid for the eyes, hoarseness, lungs, mucous buildup, nervous disorders and skin problems.

Lecithin Concentrate, Nature's Way, 400 mg, 100 Softgels Nature's Way Lecithin Supplement is 100% natural from soy oil and it contains no artificial ingredients or preservatives.

Marshmallow Root (Althaea Officinalis) Powder, 4 oz. Bulk The German Commission E approved the internal use of marshmallow root for irritation of the oral and pharyngeal mucosa and associated dry cough, and for mild inflammation of the gastric mucosa.

Niacin Supplement, Vitamin B-3, 100% Natural, Nature's way, 100 mg, 100 Caps Niacin or vitamin B-3, is necessary for normal breakdown of fats and fatty acids and the release of energy from carbohydrates. It is also an excellent vasodilator and may be useful in maintaining proper cholesterol levels.

Olive Leaf Extract, Standardized, Nature's Way, 500 mg, 60 Caps Nature's Way Standardized Olive Leaf extract is a technically advanced herbal product. Standardization assures specific measurable levels of important compounds that provide beneficial activity in the body.

Silica Complex, 8% Extract, Silica Supplement, NOW Foods, 500 mg, 90 Tabs. NOW Foods Silica Supplement is a vegetarian supplement that will help build strong and healthy hair, skin and nails.

Stabilized Oxygen OxyDrops, Liquid Electrolytes, Sodium Chloride Solution, 4 fl. oz. WaterOz stabilized oxygen is the highest quality, strongest and most stable of all the liquid electrolytes of oxygen available on the market.

Vitamin E, Natural D-Alpha Tocopherol, 400 IU, 100 Softgels Vitamin E has potent antioxidant activity, supplies oxygen to the blood, aids in strengthening capillary walls, and plays a beneficial role in cancer and cardiovascular disease prevention, anti-aging benefits, circulation, wound-healing, immune function, nervous system function, PMS, hot flushes, diabetes, vascular disease, eye health, tissue repair, athletic performance, leg cramps, skin and hair health, and alleviating fatigue.

Herbal Remedies: Raynaud's Disease Information

Herbal Remedies: Raynaud's Disease / Raynaud's Phenomenon Supplements, Information & Products

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ARTHRITIS SUPPLEMENTS

Information, supplements and products for arthritis, a disease that involves joint inflammation.

Alfalfa Leaf Root (Medicago sativa) Powder, Kosher, 4 oz. Bulk Alfalfa's deep root system pulls valuable minerals from the soil. With the aid of sunlight, nutrients including beta carotene and chlorophyll are made available to the body in a usable form.

Alfalfa, NOW Foods, 650 mg, 500 Tabs Alfalfa tablets deliver excellent health benefits. Alfalfa is a rich natural source of chlorophyll, vitamins, minerals and protein which supports a healthy colon.

Alfalfa Tincture, 100% Organic, 2 fl. oz. Alfalfa Tincture is useful to generate energy and endurance; a tonic for the whole body, due to its highly nutritive value.

Analgesic Formula, 100% Natural, 350 mg, 60 Caps Made of corydalis tuber and angelica root, this well-known formula is used in Chinese medicine for its tranquilizing, analgesic, antibacterial, and anti-hypoxia properties to regulate the Qi, promote normal blood circulation, protect mucous membrane of the stomach and to stop pain.

Antibiotic Tincture (Without Poke Root), 100% Organic, 2 fl. oz. Herbal Antibiotic Tincture (Without Poke Root) contains three well known herbs: Echinacea Root, Goldenseal Root and Cayenne Pepper.

Arnica Gel, Arniflora, 2.75 oz. topical gel Arniflora is a modern pharmaceutical preparation containing 8% tincture of Arnica montana. Relieves: Pain, Swelling, Stiffness, Bruising, Pain relieving gel for bumps, bruises, sprains, sports injuries, over-exercising, and more.

Arthritis Formula Tincture, 2 fl. oz. A combination of Herbal extracts used around the world for Arthritis, Gout, Lupus, Rheumatism and Tendonitis.

Arthritis Gel, Triflora, 2.75 oz. Triflora is a fast-acting pain relieving gel containing homeopathic extracts of 3 proven, botanical ingredients in a soothing Witch Hazel base and leaves no embarrassing locker room odor.

Arthritis Pain Homeopathic Clikpak, 84 Pellets, 100% Natural Homeopathic Nelson's Arthritis Pain Formula in the new clikpak is easy to carry and dispense for minor muscle/joint pain and other symptoms of arthritis and therefore much better suited to a busy lifestyle.

Arth-X, Natural Remedy for Arthritis, A Bone, Joint, and Ligament Nutritional Health Supplement, Trace Minerals, 90 Tabs Arth-X is the best selling bone and joint Natural Remedy for Arthritis in the industry: No other bone and join supplement contains all of the minerals and trace minerals that Arth-X does.

Arth-X Platinum, Natural Arthritis Supplement for Bone and Joint and Stiffness, Trace Minerals, 90 Tabs Arth-X Platinum is the most complete and effective dietary supplement and may be a good Natural Arthritis Treatment for you to support and aid in the relief of bone and joint pain and stiffness.

Ashwagandha Root (Withania Somnifera) Powder, 4 oz. Bulk Ashwagandha Root (Withania somnifera) is also known as Indian ginseng. Ashwagandha is useful for coughs, infertility, impotence and more.

Bio Defender, Antibacterial, Antiviral and Antifungal Formula, Balanceuticals, 56 Caps This unique antibacterial, antiviral and antifungal formula is a clinical nutritionist response to bio terrorism such as anthrax.

Black Cherry Concentrate, Organic, Kosher, Dynamic Health, 16 fl. oz. Our Black Cherry Concentrate is made from Organic Cherries, is kosher, fat free and has no sugar added.

Black Seed Gourmet Ground Seed, 3 oz. Research shows that Black Seed contains more than 100 Components, some of which are still unidentified, that work together synergistically.

Black Seed Oil, Premium Cold Pressed, 8 fl. oz. Black Seed Oil is an excellent healer, and its areas of application range from external skin care (psoriasis, eczema, dry skin, joints & scalp massage) and to internal use as a treatment for various complaints (asthma, arthritis, immune system).

Black Seed Plain, 500 mg, 100 Caps Suitable natural alternative for all types of allergic and infectious disorders of the respiratory tract, such as asthma, allergies, chronic bronchitis, emphysema, hacking cough, and other cold-like symptoms.

Black Seed Theramune Ultimate with Garlic, 100 Caps Promotes healthy circulation, useful for arthritis and cardiovascular & respiratory support. It also supports digestion and is a natural remedy for ulcers. Garlic is known to lower cholesterol naturally.

Bladderwrack (Fucus vesiculosus) Powder, 4 oz. Bulk Bladderwrack (Fucus vesiculosus) has proved most useful in the treatment of underactive thyroid glands and goiter. Through the regulation of thyroid function there is an improvement in all the associated symptoms. Where obesity is associated with thyroid trouble, this herb may be very helpful in reducing the excess weight.

Blood Circulator, 100% Natural, Jingui Huayu, 450 mg, 60 Caps This time-honored formula is used in Chinese medicine to promote micro-circulation, increase blood flow to heart muscles, open and clear arteries, inhibit intestinal adhesion, soothe the liver, remove stasis and maintain healthy blood circulation and regular menses.

Blue Scullcap (Scutellaria lateriflora), Standardized, 100 mg per Vcap, 60 Vcaps Scullcap is most commonly used as a sedative and it can take the edge off anxiety and promote sleep for those who struggle with insomnia.

Bone, Flesh & Cartilage, Nature's Way, 100 Caps Nature's Way Bone, Flesh, & Cartilage is an all-natural herbal healing formula used to energize the body's restorative function.

Borage Oil, Cold Pressed, Nature's Way, 1300 mg, 60 Softgels Nature's Way EFA Gold is the highest quality Borage Oil guaranteed to contain 24% gamma-linolenic acid (GLA).

Boron Ionic Mineral Supplement, Fully Absorbable, 20 +/- ppm, 16 fl. oz. WaterOz Ionic Boron is a pure liquid Boron supplement. WaterOz Ionic Boron is pure liquid Boron. Boron is essential to bone metabolism and calcification of bones, and helps prevent osteoporosis, arthritis, and tooth decay. Boron is necessary for cartilage formation and repair; it affects calcium, magnesium, and phosphorus levels. Memory and brain function can be improved with boron.

Boswellia (Frankincense - Boswellia serrata), C/S Powder, 4 oz. Bulk Boswellia is known as a natural bursitis and arthritis treatment.

Boswellia Tincture, 100% Organic, 2 fl. oz. Boswellia is known as a natural bursitis and arthritis treatment.

Bowel Balance Wellness Oil, 2 fl. oz. This oil works wonderfully for constipation and also for Irritable Bowel Syndrome.

Brahmi Leaf Powder (Centella Asiatica), 100% Organic, Banyan Botanicals, 1/2 lb. Nutritionally supports concentration, clarity and memory. Brahmi is traditionally used in Ayurveda as a brain and mind tonic.

Brigham Tea, Nature's Way, 415 mg, 100 Caps Brigham Tea was used by early settlers for energy and lung ailments. Brigham Tea was also used anciently to promote circulation.

Burdock Root (Arctium lappa) Powder, 4 oz. Bulk Burdock Root is traditionally used for skin disorders associated with adolescence. It is also one of the most effective herbs for cleansing the blood without the side effect of nausea.

Calcium Ionic Mineral Supplement, Fully Absorbable, 700 +/- ppm, 16 fl. oz. WaterOz Ionic Calcium is a pure liquid Calcium supplement. Calcium is one of the most essential of the major biochemical elements needed in human nutrition. It is needed in every organ of the body, including the brain. Calcium is called the "knitter" because it promotes healing or knitting everywhere in the body. It is valuable for tone, power, strength, longevity, vitality, and endurance, healing of wounds, counter-acting acids, and helping regulate metabolism.

Cat's Claw Bark (Uncaria tomentosa) Powder, 4 oz. Bulk Cat's Claw Bark (Uncaria tomentosa) was reputed to be a super drug in the Andean region of South America. It has a long history of indigenous use for arthritis and rheumatism as well as other types of inflammation associated with various stomach disorders and ulcers where it was clinically shown to be effective.

Cat's Claw Tea Spice System Builder, Regular, 100% Organic, Loose Leaf, 8 oz. Reduces inflammation in arthritis, protects the body from harmful substances, supports the body while undergoing cancer treatments, helps to boost the immune system.

Cat's Claw Tincture, 100% Organic, 2 fl. oz. Cat's Claw is a rain forest herb that grows in the Peruvian Amazon. It has been used by native healers for many years. Reduces inflammation in arthritis, protects the body from harmful substances, supports the body while undergoing cancer treatments, helps to boost the immune system.

Cat's Claw Extract, Standardized, Nature's Way, 335 mg, 60 Caps Nature's Way Cat's Claw Extract, also known as Una de Gato, is derived from the bark of plants wild-harvested in Peru and Brazil. Reduces inflammation in arthritis, protects the body from harmful substances, supports the body while undergoing cancer treatments, helps to boost the immune system.

Cat's Claw Bark, 485 mg, 100 Caps Cat's Claw supports a wide range of health problems associated with immune and digestive problems; such as gastric ulcers, arthritis, intestinal disorders, certain skin disorders, herpes, candidiasis, chronic fatigue, lupus, and tumors. It can also be used as an aid for stomach and bowel disorders including: Crohn's disease, leaky bowel, colitis, diverticulitis gastritis, ulcers, intestinal flora imbalance, and hemorrhoids.

Cayenne (Capsicum) Pepper Oil, 100% Pure, Organic, 2 fl. oz. Cayenne Pepper is beneficial for the heart, kidneys, lungs, pancreas, spleen, and stomach. When combined with other herbs, Cayenne Pepper helps increase their effectiveness by helping them enter the blood stream faster.

Cayenne (Capsicum) Tincture, 2 fl. oz. A strong stimulant, Cayenne is a digestive and heart tonic. Relaxes the stomach and colon, helps to heal ulcers, improves circulation, and stops bleeding. It stimulates the heart, increasing and strengthening the pulse.

Celadrin Topical Liposome Lotion, Joint Cream, NOW Foods, 4 fl. oz. NOW Celadrin Joint Cream can help support joint and cartilage response to physical activity, exercise and postural stability.

Celadrin & MSM, 500 mg / 100 mg Each Cap, 60 Caps Celadrin and MSM from NOW is scientifically formulated as a superior joint support formula by combining two effective and clinically tested compounds.

Celery Seed Tincture, 100% Organic, 2 fl. oz. Celery seed, an arthritis herbal remedy, also has an ancient reputation for treating muscle spasms, high blood pressure, gout, sleeplessness, depression, and anxiety.

Cell Rejuvenator, Peter Gillham's Natural Vitality, 8 oz. Cell Rejuvenator is a precisely engineered formula designed to give cells the exact nutrients they need to rejuvenate quickly and in the best condition possible.

Chaparral Tincture, 100% Organic, 2 fl. oz. Chaparral protects against the harmful effects of radiation, sun exposure, and the formation of tumors and cancer cells.

Chlorella Green Algae, Nature's Way, 410 mg, 100 Caps Green Algae Chlorella is helpful as a support for long-term debilitating systemic conditions which lower energy and resistance; such as diabetes, arthritis, high blood pressure, allergies, and infections.

Clear Head & Neck Comfort, TCM Formula, Toufengning, 100% Natural, 60 Caps Clear Head & Neck Comfort formula is made of snidium, angelica root, notopterygium rhizome and root, asarum, siler, wild mint, achizonepeta and licorice, herbs for headache.

Colon & Liver Cleanser, Truman's CAC Tea, Loose Leaf, 1/2 lb. Use of this cleansing tea has many additional benefits: improves overall digestion; strengthens the immunity; helps to prevent cancer; makes the skin more emollient and flexible: clears the eyes; and provides an overall tonic effect on the body.

Comfrey Leaf Powder, 100% Organic, 4 oz. Bulk One of the most well-known healing plants, especially for its ability to heal tissue and bone.

Comfrey Leaf Tincture, 100% Organic, 2 fl. oz. Comfrey contains allantoin, which promotes the growth of connective tissue, bone, cartilage, and is easily absorbed through the skin.

Copper Ionic Mineral Supplement, Fully Absorbable, 50 +/- ppm, 16 fl. oz. WaterOz Ionic Copper is a pure liquid Copper supplement. Copper influences protein metabolism and general healing, improves vitamin c oxidation and is integral in the formation of RNA.

Coral Calcium (Okinawa) Plus w/ Magnesium & Vitamin D, 100% Natural, 500 mg, 100 Vcaps Okinawa Coral Calcium Plus with Magnesium, Vitamin D and 70 other trace minerals provides essential minerals, restores body alkalinity, supports the immune system, and is bio available for better absorption.

Coral Calcium with ConcenTrace, Orange Vanilla, Trace Minerals, 1000 mg, 32 fl. oz. Coral Calcium with ConcenTrace® contains a highly absorbable form of every mineral needed by the body.

Corn Silk, 425 mg, 100 Caps Corn Silk was used traditionally as a mild diuretic but cornsilk herb is often included in herbal preparations for the bladder and urinary tract.

Detoxamin EDTA Chelation Therapy, Time Release Calcium Disodium EDTA, 30 Suppositories, 750 mg Detoxamin EDTA Chelation Therapy Suppositories are a new patented method of Ca-EDTA chelation therapy medically equivalent to I.V. chelation therapy.

Devil's Claw Extract, Standardized, Nature's Way, 480 mg, 90 Caps Devil's Claw is a blood cleanser that helps remove deposits in the joints and aids in the elimination of uric acid from the body. It is helpful in support for those suffering from gout, rheumatism, and arthritis.

Devil's Claw Root, 480 mg, 100 Caps In Europe today, Devil's Claw is used to treat all types of joint pain, including osteoarthritis, rheumatoid arthritis, and gout, and soft tissue pain such as back pain. It reduces inflammation and pain, and acts as a diuretic, sedative, and digestive stimulant. Devil's Claw can also be used to treat liver, gallbladder, kidney problems, and reduce menopausal symptoms.

Devil's Claw Root (Harpagophytum procumbens) Powder, 4 oz. Bulk Devil's claw root (Harpagophytum procumbens) is recognized by The British Herbal Pharmacopoeia as possessing analgesic, sedative and diuretic properties. Africans have used the herb for centuries to treat skin cancer, fever, malaria and indigestion. In Europe, the tea is recommended for arthritis, diabetes, allergies, senility and is widely utilized as an appetite stimulant and a digestive aid.

Devil's Claw Tincture, 100% Organic, 2 fl. oz. Devil's Claw is an African plant with a healing reputation for treating arthritis and myalgia. Also a diuretic and stimulates the liver, gallbladder, and lymphatic system.

DHA, 250 mg W/ 100 mg EPA & Omega 3 From Fish Oil, NOW Foods, 120 Softgels Numerous published studies have provided strong evidence that the Omega-3 fatty acids found in fish oil may reduce the risk of coronary artery disease (CAD) and sudden death from cardiac disease.

DHEA / Dehydroepiandrosterone, Pharmaceutical Grade, Anti-Aging Support, Hypoallergenic, 25 mg, 180 Caps DHEA (Dehydroepiandrosterone) is the most abundant steroid in the blood stream produced mainly in the adrenal glands. DHEA is the biochemical building blocks for the synthesis of other hormones.

DHEA / Dehydroepiandrosterone, Pharmaceutical Grade, Anti-Aging Support, Hypoallergenic, 50 mg, 180 Caps DHEA (Dehydroepiandrosterone) is the most abundant steroid in the blood stream produced mainly in the adrenal glands. DHEA is the biochemical building blocks for the synthesis of other hormones. DHEA may be used for immune system dysfunction, heart disease, diabetes, obesity, osteoporosis, arthritis, anti-aging and auto-immune diseases.

Diabetes Formula Tincture, 100% Organic, 2 fl. oz. This diabetic formula may help to decrease the amount of insulin required by the individual.

DMG Supplement N,N Dimethyl Glycine, NOW Foods, 125 mg, 100 Caps NOW Foods' DMG Supplement is a methylated amino acid found in all cells. DMG is an antioxidant and methyl donor that has a number of beneficial effects. It has shown to have potential in increasing immune response to the flu and salmonella.

DMSO Cream Complex, (Dimethylsulfoxide) 50% - 99.9% pure DMSO, 4 oz. DMSO cream contains 50% DMSO which is 99.9% pure - w/ Aloe Vera, Vitamin E, Jojoba Oil, B-Complex. DMSO is used for various applications.

DMSO Gel (Dimethylsulfoxide), 99.99% Pure, 4 oz. This pure liquid DMSO is used for various applications. DMSO is often mixed with other extracts to enhance absorption.

DMSO Liquid / Dimethulsulfoxide, 99.9% Pure Concentrate, 16 fl. oz. This pure liquid DMSO is used for various applications. DMSO is often mixed with other extracts to enhance absorption.

70% DMSO Liquid With 30% Distilled Water in Mist Sprayer, Clinic Service Co, 8 oz. DMSO may be helpful for relieving pain, inflammation, scleroderma, and interstitial cystitis however, intended use is as a solvent only and the choice of using it in other applications is the sole responsibility of the user.

EFA-Gold Mega DHA Supplement, Nature's Way, 1000 mg, 60 Softgels This Mega DHA Supplement contains the premier fish oil source of DHA, an essential fatty acid for healthy metal and visual function.

Emu MSM Cream, 1.75 oz. Emu MSM Cream is for use as an anti-inflammatory for joint pain, arthritis, tendinitis, strains, sore muscles, back, headaches, and more.

Enzyme PhytoNutrient (EPN) Ionic Supplement, Fully Absorbable, 16 fl. oz. WaterOz Ionic EPN is a pure liquid enzyme supplement. EPN complex is a patent-pending enzyme phytonutrient from a plant source that provides enzyme and saccharides necessary for optimal cellular communication. No combination of vitamins, minerals, amino acids or herbals can replace the necessary saccharides found in EPN.

Essential Oil Blend, Olbas, 100% Natural, Swiss Made, 25 cc Olbas Essential Oil Blend is a synergistic combination of six essential oils provides amazing relief on multiple levels.

Every Day Garlic Supplement, Kwai, 30 Tabs Kwai Every Day. Safety & Effectiveness. Kwai Every Day is recognized in the world's foremost medical journals because Kwai has the quality and the research to prove its effectiveness and safety. Kwai Every Day is the most scientifically proven and professionally recommended garlic supplement with allcin in the world.

Evening Primrose Oil, Cold Pressed, Nature's Way, 1300 mg, 120 Softgels Nature's Way EFA Gold is the highest quality Evening Primrose Oil, guaranteed to contain 10% gamma-linolenic acid (GLA).

Extra Strength TMG (Trimethylglycine), NOW Foods, 1000 mg, 100 Tabs TMG (Trimethylglycine) supplementation has been shown in clinical and non-clinical studies to support a healthy homocysteine level, which in turn supports healthy cardiovascular function.

Fenugreek Tincture, 100% Organic, 2 fl. oz. Fenugreek can increase breast milk supply and reduce blood sugar.

Feverfew Herb Tincture (Tanacetum parthenium), 100% Organic, 2 fl. oz. Feverfew herb is mainly used for the prevention and treatment of chronic, recurring migraine headaches.

Feverfew Leaves, Nature's Way, 380 mg, 100 Caps Feverfew leaves helps maintain normal blood vessel tone. Feverfew leaves are best used for long-term treatment and prevention of migraine headaches.

Feverfew (Tanacetum pathenium), Standardized Extract, Nature's Way, 325 mg, 60 Caps Nature's Way Feverfew extract offers the benefits of a standardized extract and full spectrum of the whole herb.

Flax Protein / Fiber / Lignan Cold Milled Powder Plus Omega 3, Certified Organic, 16 oz. With 6g Fiber / 300 mg Lignan / 5 g Protein (including 18 amino acids) per serving, Nature's Way EFAGold is one of nature's richest sources of protein, fiber & essential fatty acids.

Flax Seed Oil Super, Cold Pressed, 100% Organic (20%) Lignan Nature's Way, 16 fl. oz. Flax Seed Oil is a rich, vegetarian source of omega-3 and omega-6 essential fatty acids beneficial for allergies, cardiovascular health, cholesterol levels, circulation, eczema, eyesight, immune function, learning ability, nerve problems, osteo-arthritis, rheumatoid arthritis, diabetes, blood pressure, psoriasis, multiple sclerosis, acne, dry skin, energy levels, PMS, mood swings, and liver problems.

Flax Seed, Whole, Certified Organic, 1 lb. Bulk Flax Seeds are an important source of polyunsaturated fatty acids, including Omega-3, plus Magnesium, Zinc and dietary fiber. Flax oil from flax seeds is the richest known source of linolenic acid.

Ginger Root, 550 mg, 180 Caps Ginger root is especially useful for bowel disorders including indigestion, morning sickness, motion sickness and nausea.

Ginger Root Tincture, 100% Organic, 2 fl. oz. Ginger root has also been recommended as a treatment for atherosclerosis, migraine headaches, rheumatoid arthritis, high cholesterol, burns, ulcers, depression, impotence, and liver toxicity.

Gluco Matrix, Organic, 98% Bio-Available For Absorption, 32 fl. oz. Reduce joint pain and increase flexibility with this organic joint support.

Glucosamine Chondroitin Liquid w/ Lignisul MSM, 16 fl. oz. Liquid Glucosamine & Chondroitin with MSM combines three of the most effective nutrients available today for supporting good joint health in an easily absorbed liquid form.

Glucosamine & Chondroitin Sulfate, 500mg / 300 mg, 80 Tabs Ideal for Hands, Wrists, Knees, Back, Neck, Elbows, Hips and Ankles. Glucosamine Sulfate, lubricates damaged joint tissue by providing nutrient flow to tissue and cartilage. Chondroitin sulfate is one of the most abundant components of articular cartilage, a key component for healthy joints.

Glucosamine, MSM & Arnica Liposome Lotion, 8 oz. Massage our Glucosamine, MSM and Arnica liposome lotion into the skin as needed. Our Glucosamine/MSM/Arnica Liposome Lotion is a synergistic blend of joint and skin support factors delivered via liposome technology.

Glucosamine & MSM, High Potency, 550 mg / 250 mg each Capsule, 60 Caps Glucosamine is an amino sugar derived from the chitin of shellfish that is used by the body to support healthy joint structures. MSM is a natural form of organic sulfur found in all living organisms and is currently a popular supplement with health enthusiasts everywhere.

Glucosamine Sulfate (FlexMax), 750 mg, 80 Tabs FlexMax glucosamine sulfate is preferred by people concerned about high blood pressure because it is processed with potassium chloride rather than sodium chloride (table salt) as found in other brands.

Glucosamine Sulfate Powder, 6 oz. Glucosamine sulfate stimulates the manufacture of the substances necessary for joint repair. Glucosamine sulfate is not a band-aid approach as it works directly on the cause of the problem.

Gold Ionic Mineral Supplement, Fully Absorbable, 30 +/- ppm, 16 fl. oz. WaterOz Ionic Gold is a pure liquid Gold supplement. Gold promotes a general euphoric feeling, enhances the body's natural defenses against illness, and promotes vitality and longevity. Gold has been found to improve glandular function. It helps the body to relax.

Goldenrod Tincture, 100% Organic, 2 fl. oz. In Europe, Goldenrod is used in conjunction with other remedies and/or medications for the treatment of bladder infections, irritations of the urinary tract, and bladder or kidney stones.

Gotu Kola Powder (Centella asiatica), 100% Organic, 4 oz. Bulk Gotu kola has been used as a tonic for purification of blood and for promoting healthy skin. It has also been used to aid in restful sleep, treat skin inflammations, as a treatment for high blood pressure and as a mild diuretic.

Grape Seed Extract, 350 mg, 90 Caps A very powerful antioxidant, this standardized Grape Seed Extract helps maintain capillary health, and has the ability to neutralize free radicals.

Guggulu (Commiphora mukul), 540 mg, 120 Vcaps Guggulu is effective for arthritis, bronchitis, diabetes, fevers, weight loss, PMS, stress, and ulcers.

Gymnema Sylvestre Tincture, 100% Organic, 2 fl. oz. For diabetes, hypoglycemia, and as a digestive tonic. Used for weight reduction, to help prevent tooth decay, and restore pancreatic function. Helps to block the absorption of sugar in the digestive tract.

Harsingar Leaves (Nyctanthes arbortristis), 8 oz. Bulk Harsingar is widely used in Ayurvedic system of medicine for the treatment of sciatica, arthritis, fevers, various painful conditions and as laxative.

Hyaluronic Acid Hydraplenish with MSM and BioCell Collagen, 60 Vcaps Hydraplenish contains the patented BioCell Collagen II complex for healthy connective tissue and synovial fluid plus OptiMSM to support healthy hair.

Hyaluronic Acid Hydraplenish with BioCell Collagen, 60 Vcaps Hydraplenish contains the patented BioCell Collagen II complex for healthy connective tissue and synovial fluid.

Hyaluronic Acid Supplement with Lignisul MSM, NOW Foods, 60 Vcaps In the past few years, Hyaluronic Acid supplements have emerged as one of the most significant new dietary supplements in the health products market.

Joint Flexer, TCM Formula, Guanjieling, 60 Caps Joint Flexer uses traditional Chinese Medicine for its blood circulation promoting, stasis dispersing, analgesic, anti-inflammation, bone and tendon nurturing properties to maintain healthy joint and its functions.

Joint Formula w/ Glucosamine HCl, 60 Caps Joints Formula with Glucosamine HCl represents the powerful synergy of current scientific research and traditional herbal medicine.

Joint Pain Support, Joint Supplement, TheraVeda Nartana, 60 Vcaps TheraVeda's Joint supplement provides the benefits of both supercritical extracts and whole herbs in an innovative, patent-pending technology that uses no harmful chemical solvents.

Joint Relief, 100% Natural, 410 mg, 60 Caps Joint Relief deals with the root cause of rheumatic disorders by helping to eliminate the toxic matter in the body so all the joints can return to a healthy state.

Joint Relief Formula #1, 90 Caps The Cadillac of Joint Formulas. Joint Relief Formula #1 is recommended and sold by Chiropractors since 1997.

Joint Relief Formula #2, 90 Caps Recommendations for use as a dietary supplement for healthy adults. For joint pain.

Joint Rx, 100% Natural Joint Supplement, Pharmaceutical Grade, 600 mg, 90 Tabs Joint-Rx Natural Joint Supplement is the most comprehensive product on the market developed for arthritis, joint pain, anti-inflammatory effects, and joint structure.

Joint Support, Banyan Botanicals, 90 Tabs Accumulation of toxins in the joints can lead to discomfort and inhibit their proper functioning. Joint Support is a powerful combination of herbs formulated to remove toxins around the joints and support healthy, comfortable movement.

Joint Support Cream With Glucosamine, Boswellin & Capsaicin, NOW Foods, 4 oz. The potent blend of Glucosamine, Boswellin and Capsaicin goes on easy to help quickly ease tired, overworked joints.

Joint Tonic Extract Tincture, Herbal Remedies USA, 2 fl. oz.

Kaishore Guggulu, 450 mg, 120 Vcaps Kaishore Guggulu helps joints, muscles, arthritis, and regulates metabolism.

Kaishore Guggulu Joint & Muscle Health, Banyan Botanicals, 90 Tabs Kaishore Guggulu is particularly helpful for the accumulation of pitta in the joints and muscles, which may be indicated by pain and inflammation. Chronic accumulation can lead to serious conditions such as bursitis, tendonitis and arthritis.

Kaishore Guggulu Powder, 100% Organic, 8 oz. Bulk For joints, muscles, arthritis, and to regulate metabolism.

Kelp Seaweed Norwegian, NOW Foods, 100% Natural Acophyllum nodosum, 550 mg, 250 Caps Norwegian Kelp seaweed contains nearly 30 minerals which nourish the glands, especially the thyroid and pituitary. Kelp, also known as seaweed, grows in the rich ocean beds, far below surface pollution levels.

Kombucha Tea Extract Tincture, Certified 100% Organic, 1 fl. oz., Case of 12 People from all over the world claim drinking Kombucha Tea provides relief from many physical ailments.

Kombucha Tea, 100% Organic, Original Flavor, 12 fl. oz., Case of 24, Ready To Drink People from all over the world claim drinking Kombucha Tea provides relief from many physical ailments. Kombucha Tea offers many people the physical resistance they need to maintain and restore health.

Kombucha Tea, 100% Organic, Original Flavor, 25.4 fl. oz., Case of 12, Ready To Drink People from all over the world claim drinking Kombucha Tea provides relief from many physical ailments. Kombucha Tea offers many people the physical resistance they need to maintain and restore health.

Kombucha Tea, 100% Organic, Original Flavor, 64 fl. oz., Case of 6, Ready To Drink Kombucha's benefits to the physical body vary widely. It is said to enhance the immune system. By detoxifing the body, kombucha makes it unlikely for disease causing bacteria and viruses to find a suitable growth environment. This results in a healthier physical body!

Kombucha 2000, Concentrated Kombucha, 30 Caps Concentrated Kombucha Capsules are new to the market, but Kombucha 2000 is one of the very first successful kombucha tea producers in the United States.

L-Cysteine Structural Support, W/ Vitamin B-6 & C, Vegetarian, NOW Foods, 500 mg, 100 Tabs L-Cysteine functions as an antioxidant and is a powerful aid to the body in protecting against radiation and pollution. Hair and skin are made up 10-14% Cysteine.

L-Histidine, 500 mg, 60 Tabs L-Histidine has been used in the treatment of rheumatoid arthritis, allergic diseases, ulcers and anemia.

Liquid Glucosamine / Chondroitin / MSM, Trace Minerals, 16 fl. oz. Liquid Glucosamine / Chondroitin / MSM is a potent formula loaded with nutrients that help to provide nutritional support for joints and connective tissue.

Liquid Glucosamine with MSM, Natural Peach Mango Flavor, Trace Minerals, 16 fl. oz. Introducing Liquimins, Liquid Glucosamine with MSM, ionically charged liquid minerals from Trace Minerals Research.

L-Phenylalanine, Free-Form, NOW Foods, 500 mg, 60 Caps L-Phenylalanine is an essential amino acid that helps to elevate positive mood and may be used in the treatment of some forms of depression. It is essential for the production of adrenalin.

Lubri Joint, Inholtra Premium, 90 Gelcaps Two forms of Glucosamine in this formula combine with Chondroitin to produce a powerful joint rebuilding effect, repairing the smooth rubber-like padding (cartilage) covering the ends of bones so painful inflammation does not occur.

Maca (Lepidum meyenii) Tincture, 100% Organic, 2 fl. oz. Today Maca is used to increase energy and support the immune system. Maca can help a number of conditions from fatigue to frigidity.

Manuka Honey & Bee Venom, Actiflex, GMO Free, 8 oz. Manuka Honey & Bee Venom, Actiflex - GMO Free has been used to enhance the immune systems battle against Arthritis & MS. Combined Pure Organic Manuka Honey and Bee Venom direct from New Zealand.

Momordica Powder (Momordica charantia), Alternative Health & Herbs, 4 oz. Momordica Charantia is an antibiotic, antiviral, immunosuppressive, insulinomimetic, and hypotensive. Also known as Bitter Melon, Momordica is used for diabetes, rheumatoid arthritis, systemic lupus erythematosus. Lowers blood sugar. Momordica is an antibiotic, antiviral, immunosuppressive, insulinomimetic, and hypotensive.

MSM (Methylsulfonylmethane) Liquid, Pure Lignisul, 16 fl. oz. MSM is a non toxic physiologically active sulfur compound that may be helpful for connective tissue, cartilage, tendons, mucous membranes, nails, hair, and skin damage and repair.

MSM (Methylsulfonylmethane) Lotion, 15%, 8 fl. oz. MSM Lotion contains methylsulfonylmethane, a form of sulfur, which may be helpful in treating skin disorders including acne, psoriasis, eczema, dermatitis, dandruff, scabies, diaper rash, and certain fungal infections.

MSM (Methylsulfonylmethane) Lotion With Aloe, 4 fl. oz. MSM lotion with aloe vera supports healthy skin, helping to keep it moisturized and smooth throughout the day.

MSM (Methylsulfonylmethane), Pure Lignisol, 4 oz. MSM plays a beneficial role in allergies, connective tissue and joint flexibility.

MSM (Methylsulfonylmethane), Pure Lignisul, 1000 mg, 240 Caps With many benefits, MSM plays a beneficial role in connective tissue and joint flexibility, immune health, arthritis, osteoporosis, nails, fibromyalgia, muscle soreness, athletic injuries and allergies.

MSM (Methylsulfonylmethane), Pure Lignisul, 500 mg, 250 Caps MSM is a non toxic physiologically active sulfur compound that may be helpful for connective tissue, cartilage, tendons, mucous membranes, nails, hair, and skin damage and repair.

MSM (Methylsulfonylmethane), Pure Lignisul, With Glucosamine, 500 mg, 120 Caps MSM with Glucosamine provides nutritional support for healthy joints by lubricating, nourishing, and easing, inflammation in damaged tissue and cartilage.

MSM (Methylsulfonylmethane) Supplement, Pure Lignisul With Free 4 oz. Lotion, 1000 mg, 120 Caps Buy MSM Supplement caps and get a free 4 oz. lotion. MSM supplement plays a beneficial role in connective tissue and joint flexibility, immune health, arthritis, osteoporosis, rheumatoid arthritis, inflammation, pain, hair, skin, nails, athletic injuries, acne, wrinkles and allergies.

MSM (Methylsulfonylmethane), With Vitamin C, 875 mg/ 100 mg, 120 Caps MSM with Vitamin C offers support for allergies, connective tissue, joint flexibility, immune function, arthritis, osteoporosis, digestive disorders, circulation,bruising, carpal tunnel syndrome, and antioxidant protection.

MSM (Methylsulfonylmethane), Ultra Fine Powder, 1 lb. Helps rejuvenate joints and all body cells, lessens the pain and stiffness of arthritis, boosts energy level.

Multiple Effects Oil, TCM Cold, Headache and Pain Formula, 100% Natural, 0.34 fl. oz. Multiple-Effects Oil - TCM Cold, Headache and Pain Formula opens stuffy noses, removes headache pain, joint pain and drowsiness.

Myrrh Oil (20%) in Grape Seed Oil Base, NOW Foods, 100% Natural, 1 fl. oz. Natural Myrrh Oil from NOW Foods contains the essential oil Myrrh pre-diluted in a natural base of Grape Seed Oil.

Natural Aspirin Alternative, 390 mg White Willow Bark Extract, 60 Tabs Used to treat bursitis, tendonitis, headaches, osteoarthritis, dysmenorrhea, rheumatoid arthritis, back pain, toothache, and menstrual cramps, White Willow is being used by more people as a safer, natural alternative to aspirin.

Natural Menthol Analgesic Salve, Swiss Made, Olbas, 1 oz. Tube This Analgesic Menthol Salve delivers a combination of deep, penetrating relief of aches and pains in muscles and joints, and is particularly effective to soothe backaches and the inflammation and discomforts from arthritis, strains, bruises and sprains.

Nerves Formula Tincture, 100% Organic, 2 fl. oz. The Nerves Formula was created to help calm and soothe the nerves. Can also help arteriosclerosis/atherosclerosis, arthritis, auto-immune diseases.

Nettle Herb, Nature's Way 435 mg, 100 Caps Nettle herb from Nature's Way is wild harvested, gently dried and ground to a usable form and encapsulated. Nettle herb contains no chemicals, additives or artificial coloring.

Nettle Leaf (Urtica dioica) Powder, 4 oz. Bulk Nettle Leaf from ancient Greece to the present, nettle has been documented for its use in treating coughs, tuberculosis, and arthritis, asthma and in stimulating hair growth.

Nettle Leaf Tea, Organic, 30 Tea Bags Nettle tea has an earthy refreshing flavor and aroma. This Nettle tea is 100 percent organic.

Nettle Tincture, 100% Organic, 2 fl. oz. Nettle Leaf has become a popular treatment of allergies (hay fever) and it can improve goiter, inflammatory conditions and arthritis.

Noni Juice (Morinda citrifolia), Certified Organic, Tahitian, Raspberry Flavor, Dynamic Health, 32 fl. oz. Pure Noni Juice, aids digestion, eases arthritis and allergy symptoms, and helps eliminate parasites.

Noni Juice, 100% Pure Organic Certified, Kosher, Tahitian, Dynamic Health, 32 fl. oz. Pure Noni Juice, aids digestion, eases arthritis and allergy symptoms, and helps eliminate parasites.

Oat Straw Tincture, 100% Organic, 2 fl. oz. Oat Straw is most often used as a topical remedy for irritated and inflamed dry skin.

Odorless Garlic Supplement, NOW Foods, 50 mg, 250 Softgels Odorless Garlic supplement is extracted from Allum sativum and is a specially made Japanese product. Our Odorless Garlic yields high amounts of Scordiin, a unique sulfur compound which may be responsible for many of garlic's renowned benefits.

OJ Soothe, PCK Technologies Inc, MagiHerbs, 500 mg, 60 Caps This 100% natural herbal formula is based on Chinese decoctions proven effective to relieve chronic musculo-skeletal disorder symptoms, including heel pain, painful, swollen, deformed, non-flexible or stiff joints and muscles, etc. but without open wound, red-hot skin or bone fracture.

Olbas Sampler Kit, Herbal Remedies, All Natural Ingredients Olbas Soothes Herbal Remedies Sampler Kit has everything you need to relieve cold, flu and bronchitis symptoms and to provide pain relief and invigorate your body after strenuous sport activities or exercise.

Olive Leaf Extract, Standardized, Nature's Way, 500 mg, 60 Caps Nature's Way Standardized Olive Leaf extract is a technically advanced herbal product.

Omega 3 Fish Oil (200 ml), 7 oz Lemon Flavored, All Natural Omega 3 Fish Oil is important for mental and cardiac development.

Omega 3 Fish Oil Mood Aid, EFA Gold, Enteric Coated, 60 Softgels Research suggests a correlation between consuming more omega-3 fatty acids from fish and better emotional health. MoodAid provides a convenient way to add an effective amount to your diet.

Oregon Grape Root (Mahonia aquafolium) Powder, 4 oz. Bulk Oregon Grape Root (Mahonia aquafolium) was used by Native Americans as a tea to treat jaundice, arthritis, diarrhea, fever, and many other health problems.

Oregon Grape Root (Wild) Tincture, 100% Organic, 2 fl. oz. Oregon Grape Root is used as a treatment for skin diseases and as a treatment for prostate infection.

Organic Apple Cider Vinegar (Mother), Dynamic Health, 16 fl. oz. Dynamic Health Organic Apple Cider Vinegar is made from the juices of Organic certified grown apples.

Orthogel Pain Relief, Orthopedic Pharmaceuticals, 4 oz. Tube Orthogel Advanced Pain Relief Gel 4 oz Tube with Menthol, Camphor, OptiMSM, Pureflex Glucosamine, Aloe, Vitamin E, Curcumin and Boswellia Serrata. Orthogel is a topical analgesic for the temporary relief of pain.

OsteoBoron Bone and Joint Health, with 200 mg Green Food Concentrates each, 90 Vcaps Boron is an important trace mineral for bone and joint health throughout life, as well as for the development and maintenance of healthy bone density. NOW OsteoBoron is a superior form of Boron that has been the subject of clinical studies demonstrating its efficacy in the support of healthy joints.

PABA / Para-aminobenzoic Acid, NOW Foods, 500 mg, 100 Caps PABA is a non-essential member of the B-vitamin family. PABA has been reported to enhance the effects of cortisone.

Pain Formula Tincture, 100% Organic, 2 fl. oz. Use the Pain Formula to alleviate pain naturally.

Pain Relief Cream With 42% Pure Ultra Aloe, Miracle Rub, 3.5 oz. No matter what else you have tried, Miracle Rub will relieve your body's aches and pains.

Poke Root Tincture, 100% Organic, 2 fl. oz. Poke Root is usually used in combination with other herbs to cleanse the lymph. Use externally for skin infections, scabies, eczema, parasites, and other skin problems.

Potassium Ionic Mineral Supplement, Fully Absorbable, 340 +/- ppm, 16 fl. oz. WaterOz Ionic Potassium is a pure liquid Potassium supplement. Potassium aids rheumatic or arthritic conditions and is vital for the elimination of wastes.

Pregnenolone (Preg), Pharmaceutical Grade, 30 mg, 150 Capsules Pregnenolone is used for enhanced brain function, memory deficiencies, Alzheimer's disease, mood disorders, chronic fatigue, cholesterol levels, lupus, immune weakness, multiple sclerosis, psoriasis, rheumatoid arthritis and stress.

Prickley Ash Bark Tincture, 100% Organic, 2 fl. oz. Prickly Ash Bark is an alterative, antispasmodic, blood purifier, and stimulant.

Prickley Ash (Zanthoxylum Americanum) Powder, 4 oz. Bulk Prickly Ash is an alternative, antispasmodic, blood purifier and stimulant. The Prickly Ash is a small North American tree growing in the open air in this country.

Procaine Ultra GH9 (Ultimate 9), 100 mg, 60 Caps Procaine Ultra GH9 is the MOST TRUSTED Anti-Aging THERAPY - of choice of the RICH & FAMOUS in over 70 countries.

Pure Emu Oil, 100% Pure, Naturally Refined, 8 fl. oz. Thunder Ridge's Pure Emu Oil is a natural skin softener and protector. This pure Emu Oil supports skin hydration and elasticity and improves skin surface blood flow & healing.

Pycnogenol W/ Vitamin E, 100% Natural, Nature's Way, 50 mg, 30 Tabs The proanthocyanidins in Pycnogenol are potent antioxidants and provide protection for collagen and connective tissues. Pycnogenol is a concentrated source of proanthocyanidins, organic acids and other biologically active components.

Red Reishi Mushroom Tincture, 100% Organic, 2 fl. oz. Red Reishi is called Ling Zhi and it is believed to be one of the ingredients for youth elixirs.

Rheumatism Formula Tincture, 100% Organic, 2 fl. oz. Helps to alleviate the pains of rheumatism, arthritis, bursitis, lumbago, lupus, muscular problems, and tendinitis.

Samento (Uncaria Tomentosa) Extract, 0.5% POA, 1 fl. oz. Beneficial in the treatment of a wide range of immune system related conditions; these include but are not limited to cancer, arthritis, bursitis, rheumatism, allergies, ulcers, systemic candidiasis, all forms of herpes, diabetes, lupus, chronic fatigue syndrome, intestinal disorders and HIV infection.

Samento (Uncaria Tomentosa), Extra Strength (100 Times More Effective than regular Cat's Claw), 0.5% POA, 600 mg, 30 Caps Samento is beneficial in the treatment of a wide range of immune system related conditions; these include but are not limited to cancer, arthritis, bursitis, rheumatism, allergies, ulcers, systemic candidiasis, all forms of herpes, diabetes, lupus, chronic fatigue syndrome, intestinal disorders and HIV infection.

SAM-e with B Vitamin Cofactors, Vegetarian, Enteric Coated, 200 mg each Tablet, 60 Tabs Important for the production of glutathione, this powerful free radical scavenger defends the body from toxic agents and is necessary for liver detoxification.

Sassafras (Sassafras officinale) Powder, 4 oz. Bulk Sassafras has been used as a stimulant, diaphoretic, and alternative.

Sea Buckthorn Seed Oil, 100% Natural, 500 mg, 60 Softgels A rare source of vitamin E, Sea Buckthorn Oil also provides other vitamins including Vitamins A, C, D, K, etc, carotenoids, flavonoids, phytosterols, amino acids, serotonin and 28 trace elements: iron, zinc, calcium, magnesium, selenium, iodine, etc.

Selenium Supplement, Yeast Free, NOW Foods, 200 mcg, 180 Caps Selenium is an essential trace mineral in the human body. NOW Foods Selenium Supplement is an important part of antioxidant enzymes that protect cells against the effects of free radicals that are produced during normal oxygen metabolism.

Sea Minerals With Silver & Sea Greens, Dynamic Health, 32 fl. oz. This unique formulation has dynamic ingredients that work together synergistically to bring your cells to an optimum performance level.

Shark Cartilage, 750 mg, 100 Caps Shark cartilage is taken to ease the pain and inflammation of arthritis and other bone and joint ailments. Popular as an alternative treatment for cancer, shark cartilage is taken both to slow the growth of existing tumors and in smaller daily doses to prevent new cancers.

Silver Biotics Liquid, Silver Supplement, 8 fl. oz. Silver Biotics was tested by researchers and was found to kill every strain of bacteria that it was tested against and that these bacteria, many of which have become resistant to antibiotics, cause many human ailments.

Sulfur Ionic Mineral Supplement, Fully Absorbable, 500 +/- ppm, 16 fl. oz. WaterOz Ionic Sulfur is a pure liquid Sulfur supplement. increases blood circulation, reduces back pain, relieves migraine headaches, promotes muscle healing, scavenges free radicals, beautifies the skin, relieves allergies to food, controls acidity in stomach ulcers, is important for carbohydrate metabolism and speeds wound healing.

Super Digestive Enzymes, 90 Caps Super Digestive Enzymes contain a complete and balanced digestive enzyme formula.

Sutherlandia (Sutherlandia frutescens), 300 mg, 60 VegiTabs Sutherlandia powerfully assists the body to mobilize its own immunological physiological resources to cope with diverse physical, mental, and chemical stressors.

Swedish Bitters Capsaicin Cream, NatureWorks, 4 oz. Swedish Bitters Capsaicin Cream contains cayenne pepper and Swedish bitters and is suggested for the temporary relief of aches and pains in muscles and joints due to arthritis, backache, strains and sprains, and may be used to revitalize after strenuous exercise.

Synthovial Seven, Pure Hyaluronic Acid, 1 oz. Hyaluronic Acid (HA) has been proven by numerous medical studies to alleviate pain and suffering from arthritis of the knee and other joints.

3 In 1 Joint Formula, 90 Gelcaps This powerful formula is the world's first product to support joint health in three distinct ways.

Three Mushroom Tincture, Red Reishi, Shiitake & Maitake Mushroom Extracts, 100% Organic, 2 fl. oz. Three Mushroom Liquid Tincture supplement contains Red Reishi, Shiitake and Maitake Mushroom extracts.

Tiger Balm Ointment, Extra Strength, Red Sports Rub, 0.63 oz. Tiger Balm Red has successfully been used to relieve sore and achy muscles, ease back pain, soothe headaches and clear sinuses. Tiger Balm Red helps increase blood circulation as well.

Tiger Balm Ointment, Regular Strength, White Sports Rub, 0.63 oz. Tiger Balm White has a higher concentration of mint oil than the red balm which help relieve muscular aches and pains, increase circulation in arthritic joints and ease soreness after a working out.

Tiger Balm Ointment, Ultra Strength, Non-Staining Sports Rub, Natural Pain Relief, 1.7 oz. Tiger Balm Ultra sports rub for sore muscles and overexertion.

Tiger Balm Patch, 5 (4 x 2.74 inch) Patches Tiger Balm Patch uses a new delivery technology to deliver it's well known pain-relieving formula to where it hurts.

Tremor Support Wellness Oil, 2 fl. oz. The Tremor Support Wellness Oil was designed with Parkinson's Patients in mind.

Tri-Amino / L-Arginine, L-Ornithine, L-Lysine, NOW Foods, 775 mg, 120 Caps Tri-Amino, an amino acid supplement, is a comprehensive product that combines three essential amino acids into one easy to take formula.

Trifala Guggulu Powder Blend, 8 oz. Bulk Effective for arthritis, bronchitis, diabetes, fevers, weight loss, PMS, stress, and ulcers. It lowers cholesterol too.

Triple Action Advanced Joint Support Formula, California Natural, 120 Caps Triple Action Advanced Joint Support Formula is a full strength joint support supplement utilizing a formula of proven ingredients (Glucosamine Sulfate, Chondroitin Sulfate and MSM) to provide maximum relief from joint pain, stiffness and swelling.

Turmeric (Curcuma longa) C/S Powder, 4 oz. Bulk Turmeric is useful as an anti-inflammatory and can be used to reduce Alzheimer's debilitating effects, but there are multiple studies that suggest curcumin can have some potential in actually treating various forms of cancer.

Unker's Medicated Salve, 3.5 oz. Unker's for the temporary relief of pain and itching associated with minor cuts, scrapes, minor burns, sunburns or minor skin irritations.

Unker's Medicated Salve, 7 oz. Unker's Medicated Salve has been providing healing and relief for over 60 years. It works great for arthritis, sore muscles and joints, cuts, burns, bruises, throat congestion, sinus problems, psoriasis, and much more.

Unker's Natu-Rub, All Natural Liquid Medicated Salve, 1 fl. oz., Up To 200 Applications This all natural liquid version of Unker's medicated salve absorbs into the skin quickly.

Valerian Root (Valeriana officinalis) Tincture, Alcohol Free With Glycerin, 100% Organic, 1 fl. oz. Most known for its sedative effect on the central nervous system. It is used for anxiety, nervous tension, insomnia, and general stress symptoms.

Vitamin B-100 Complex W/ Coenzyme B-2, Nature's Way, 631 mg, 100 Caps A complete Vitamin B complex of 8 essential vitamins. B Vitamins are precursors of coenzymes involved in the conversion of cellular energy, manufacture of hormones and proteins, and repair and maintenance of nerve structures.

Vitamin B-3 (Niacinamide - Non-Flushing Niacin), 100% Natural, Nature's Way, 500 mg, 100 Caps The benefits of Niacin without the discomforts associated with a Niacin flush. Nature's Way Niacinamide is 100% natural.

Vitamin B-5 (Pantothenic Acid), 100% Natural, Nature's Way, 250 mg, 100 Caps Pantothenic acid (vitamin B-5) is converted to coenzyme A, which is involved in the biochemical cycles responsible for conversion of fats, proteins and carbohydrates into energy.

Vitamin B-6 (Pyridoxine), 100 mg, 100 Caps Vitamin B-6 (pyridoxine) is converted in the body to the main coenzyme responsible for amino acid and protein metabolism.

Vitamin B-9 (Folic Acid), 100% Natural, Nature's Way, 800 mcg, 100 Caps Folic Acid (vitamin B-9) is necessary precursor for the manufacture of genetic material like RNA and DNA. It also assists in the growth and repair of tissues and in the conversion of fats and amino acids into other useful products in the body.

Vitamin B-12 (Cobalamin) Liquid Supplement, 50 mcg, & B-9 (Folic Acid), 400 mcg, 1 fl. oz. This liquid B-12 supplement with its combination of B vitamins can be a very effective revitalizer in supporting the nervous system, prenatal child health, vegetarians, and heart health.

White Flower Balm, 0.67 fl. oz. Use White Flower Balm, for the temporary relief of minor aches and pains of muscles and joints associated with simple headache, arthritis, sprains, bruises, and strains.

Wild Yam Tincture, 2 fl oz. Alternative Health & Herbs Remedies Wild Yam Supplement relaxes muscles, soothes nerves, and relieves pain and is good as a uterine tonic.

Wintergreen Essential Oil (Gaultheria procumbens), 100% Pure, 100% Natural, 1 fl. oz. Wintergreen essential oil is used for everything from arthritis to tendonitis.

Wolfberry Tincture, Goji Juice Concentrate (Lycium Barbarum), 100% Organic, 2 fl. oz. Wolfberry (Goji) has healing benefits of nourishing and strengthening the eyes, liver, kidneys and nourishing the blood.

Wormwood (Artemisia absinthium) C/S Powder, 4 oz. Bulk Wormwood is above all a stomach medicine, being useful for indigestion, gastric pain and lack of appetite, as well as the related problems of heartburn and flatulence.

Wormwood Double Blend, 365 mg, 100 Caps Wormwood is above all a stomach medicine, being useful for indigestion, gastric pain and lack of appetite, as well as the related problems of heartburn and flatulence.

Wormwood Herb Tincture, 100% Organic, 2 fl. oz. Wormwood Herb is above all a stomach medicine, being useful for indigestion, gastric pain and lack of appetite, as well as the related problems of heartburn and flatulence.

Yogaraj Guggulu, Healthy Joints, Nerves & Muscles, Banyan Botanicals, 90 Tabs Yogaraj Guggulu is a traditional formula designed to reduce excess vata in the system. It is particularly useful for accumulated vata in the joints and muscles, which may be indicated by cracking or popping joints, tics, spasms or tremors. Chronic accumulation may lead to such serious conditions as rheumatism and arthritis.

Yograj & Guggulu Blend, 100% Natural, 525 mg, 50 Caps Yograj & Guggulu Blend, an Ayurvedic herbal preparation, has been used for numerous conditions, such as skin diseases, diabetes, whooping cough, and arthritis.

Yucca (Yucca filimentosa) Tincture, 100% Organic, 2 fl. oz. Yucca is a desert plant that was used by the Southwestern Indians for skin disorders, eruptions, slow healing ulcerations, to stop bleeding, and as a poultice for breaks, sprains and rheumatism.

Zinc (Chelated), 100% Natural, Nature's Way, 30 mg, 100 Caps Zinc is present in all tissues, organs and secretions of the body. Nature's Way chelated zinc is 100% natural chelated with an advanced amino acid complex for superior absorption.

RECOMMENDED READING

Acupressure's Potent Points Guide To Self-Care For Common Ailments, By Michael Reed Gach Acupressure is an ancient healing art that uses the fingers to stimulate key points on the skin that, in turn, activate the body's natural self-healing processes.

Clay Cure: Complete Healing From The Earth, By Ran Knishinsky Naturally absorbent and extremely gentle on the system, clay can treat ailments affecting digestion, circulation, menstruation, and the liver, skin, and prostate. Clay also remedies symptoms of arthritis, chronic fatigue syndrome, gum diseases, and migraines. The Clay Cure contains complete and up-to-date information on choosing the appropriate type and form of clay, how and when to take it for your specific complaint, the science and history of ingesting clay, and the value of minerals contained in the many varieties of clay.

Colostrum Nature's Gift To The Immune System, Revised & Updated, By Beth Lev, Ph.D. Colostrum offers help for auto-immunity (Arthritis, Multiple Sclerosis, Allergies, Asthma) immune deficiency, Cancer, Inflammation, etc. plus offers Growth Factors to benefit Athletes and Body Builders (speeds tissue healing).

DMSO Nature's Healer, DMSO Treatment, By Dr. Morton Walker (Paperback) DMSO Nature's Healer is Dr. Morton Walker's educational book on the use of DMSO treatment for many debilitating diseases and health-related problems.

Dr. Atkin's Health Revolution Powerful and forthright, Dr. Atkin's Health Revolution calls for dramatic changes in the way medicine is practiced in America.

Earl Mindell's Vitamin Bible For The 21st Century, Revised Edition, By Dr. Earl Mindell Earl Mindell's Vitamin Bible For The 21st Century is America's #1 reference book for all aspects of vitamin and mineral supplements. Includes more information on nutriceuticals, supplements, herbs and homeopathic medicines.

Encyclopedia Of Healing Foods, By Michael Murray, N.D. & Joseph Pizzarno, N.D. Providing the best natural remedies for everyday aches and pains, as well as potent protection against serious diseases, The Encyclopedia of Healing Foods is a required daily health reference.

Encyclopedia Of Natural Medicine, By Michael Murray, N.D. Details the naturopathic approach to prevention and treatment of over 70 common ailments, diseases, and dysfunctions. Tells how to use herbs, vitamins, minerals, foods and nutritional supplements safely and effectively in the home treatment of physical ills.

Encyclopedia Of Nutritional Supplements: The Essential Guide for Improving Your Health Naturally, By Michael T. Murray, N.D. The companion volume to the Encyclopedia of Natural Medicine offers detailed profiles of vitamins, minerals, essential fatty acids, and other nutritional supplements. What sets this guide apart from similar works is the impressive list of references for each entry (55 pages in total).

Enzymes, Nature's Energizer, By Anthony J. Cichoke Learn to heal many degenerative diseases and other life-threatening conditions, including vital infections, circulatory problems, cancer, arthritis, poor digestion and aging.

Fish Oil Update, By Richard Passwater, Ph.D. Why and how marine lipids exercise and beneficial effect on many degenerative diseases such as lupus, arthritis, migraines, heart disease and even cancer.

Flax Oil As A True Aid Against Arthritis, Heart Infarction, Cancer & Other Diseases, By Dr. Johanna Budwig This book contains the lectures by seven-time Nobel prize nominee and the world-renowned Scientist & Biochemist that have brought about a scientific revolution connecting the relationship between Cancer & Fat Metabolism.

Get A Grip on Arthritis & Other Inflammatory Disorders, By Lorna R. Vanderhaeghe Get a Grip on Arthritis and Other Inflammatory Disorders arms you with knowledge of natural relief for the pain, swelling and destruction that inflammation causes in the body.

How To Prevent And Treat Diabetes With Natural Medicine This diabetes book is a comprehensive and user-friendly guide to defeating one of our fastest growing health problems provides.

Hydrogen Peroxide & Ozone, By Conrad LeBeau Reveals documented details of the use of hydrogen peroxide as a successful treatment for many disorders, including arthritis, cancer and AIDS.

Kombucha Miracle Fungus, Kombucha Tea Benefit's, By Harald Tietze, Paperback One time best seller, Kombucha Miracle Fungus is all about synergy and Kombucha Tea Benefit's it is an easy read for those interested in the synergy Kombucha offers or Kombucha benefit's.

Lick The Sugar Habit, By Nancy Appleton, Ph.D. Nancy Appleton, Ph.D., shows you how sugar upsets the body chemistry and devastates the endocrine and immune systems, leading to a host of diseases and conditions including hypoglycemia, diabetes, osteoporosis, arthritis, cancer, heart disease, headaches, allergies, asthma, obesity, periodontal disease, tooth decay, and more.

More Precious Than Gold; The Story of Pascalite, By Ray Pendergraft This book tells the story of Pascalite and of the benefits of calcium bentonite.

Natural Treatments For Diabetes, By R. N. Ellsworth This Book offers essential information on the types of diabetes and symptoms, as well as dietary recommendations, and current research.

Reversing Diabetes, Revised and Updated, by Julian Whitaker, M.D. This bestselling guide will arm you with safer and equally effective ways of treating diabetes through a sensible diet, exercise, and specific nutritional supplement suggestions. You can improve blood sugar control, reduce if not eliminate reliance on medication, decrease risk of complications and diseases associated with diabetes.

SAMe S-Adenosyl-Methionine: The Remarkable Substance That Promotes Detoxification, Relieves Arthritis, and Fights Depression, By Rita Elkins, M.H. Woodland Health Series - This booklet provides valuable information on the breakthrough research, safety and therapeutic uses of this amazing natural substance that promotes detoxification, relieves arthritis and fights depression.

The Arthritis Cure: The Medical Miracle That Can Halt, Reverse, and May Even Cure Osteoarthritis, By Jason Theodosakis, M.D. Brenda Adderly, Barry Fox, Terry J. Dubrow This ground-breaking book describes the medical miracle that can halt, reverse or even cure osteoarthritis without drugs or pain killers. Two natural supplements glucosamine and chondroitin sulfate are at the core of this program.

The Green Pharmacy: The Ultimate Compendium Of Natural Remedies From The World's Foremost Authority On Healing Herbs, By James Duke, Ph.D. The world's foremost authority on medicinal plants and herbs shares his knowledge of thousands of safe, natural remedies that lie untapped in jungles, forests and herbal gardens throughout the world as hidden reserves of healing power.

The Miracle of MSM: The Natural Solution for Pain, By Stanley W. Jacob M.D., Ronald M. Lawrence M.d. & Martin Zucker Learn how to stop the pain of numerous ailments with MSM. How much, when, with what food and in what form to relieve pain in its many forms. Helpful against pain and allergies, this supplement is safe, natural and side-effect-free.

Tongkat Ali: The Tree That Cures A Hundred Diseases, By W.G. Goreja This potent aphrodisiac is derived from the roots of the E. Longifolia tree, which grows deep within the jungles and rain forests of Borneo and other areas of Indonesia.

HOT & COLD PACKS FOR JOINT PAIN RELIEF

Hot and Cold Gel Pack, CorPak Soft, 3" x 5", 1 Each Treat your strains, sprains, tendonitis and other injuries with a CorPak Soft Hot & Cold Pack. 3" x 5"

Hot and Cold Gel Pack, CorPak Soft, 6" x 10", 1 Each Treat your strains, sprains, tendonitis and other injuries with a CorPak Soft Hot & Cold Pack. 6" x 10"

Hot and Cold Gel Pack, CorPak Soft, 10" x 13", 1 Each Treat your strains, sprains, tendonitis and other injuries with a CorPak Soft Hot & Cold Pack. 10" x 13"

Hot and Cold Gel Pack, CorPak Soft, 6" x 20", 1 Each Treat your strains, sprains, tendonitis and other injuries with a CorPak Soft Hot & Cold Pack. 6" x 20"

Hot and Cold Gel Pack with 12" Strap, Packaged in Plastic Bag, CorPak, 6" x 20", 1 Each Treat your strains, sprains, tendonitis and other injuries with a CorPak Hot & Cold Pack. 6" x 20"

Hot and Cold Gel Pack with 18" Strap, Packaged in Plastic Bag, CorPak, 9" x 16", 1 Each Treat your strains, sprains, tendonitis and other injuries with a CorPak Hot & Cold Pack. 9" x 16"

Hot and Cold Gel Pack with 6" Strap, Packaged in Plastic Bag, CorPak, 3" x 5", 1 Each Treat your strains, sprains, tendonitis and other injuries with a CorPak Hot & Cold Pack. 3" x 5"

Hot and Cold Gel Pack with 18" Strap, Packaged in Plastic Bag, CorPak, 6" x 10", 1 Each Treat your strains, sprains, tendonitis and other injuries with a CorPak Hot & Cold Pack. 6" x 10"

PET CARE

Hyaflex Oral Hyaluronic Acid For Your Pets, 1 oz. Hyaflex is our premium liquid oral hyaluronic acid specially formulated for pets. Your best friend can now enjoy the benefits of oral hyaluronic acid. 30 ml (1 oz.) is approximately one months supply.

Joint & Hip Formula for Dogs and Puppies, Pet Vitamin Supplement Enriched with Glucosamine and Chondroitin, 8 fl. oz. The Joint & Hip Formula for Dogs and Puppies (Pet Vitamin / Supplement) is an excellent source of Glucosamine, Chondroitin and calcium. Also provides Linoleic Acid, Linolenic Acid, Eicosapentanoic Acid (EPA), Docosahexaenoic Acid (DHA), Salmon Oil (Essential Fatty Acids), Vitamin Enriched.

Joint Rescue, Super Strength, Chewables, Joint Supplement, 90 Wafers Ark Naturals Joint Supplement "Rescues" your pet from chronic arthritis pain, relieves swollen joints, morning stiffness, inability to run and play as well as age related immobility.

Nu Pet Granular Greens Pet Supplement Ark Naturals Nu-Pet Granular Greens Pet Supplement provides the supplementation your pet needs that's missing from their everyday diet.

JOINT SUPPORT, MAGNETIC THERAPY & JEWELRY

AB Contour Pillow - Satin Blue, Core Products The AB Contour Pillow is designed to provide comfortable support for an aching neck and shoulders. The unique contour shape can support your neck in it's most natural position, helping to relieve cervical strain, tension headaches. Using this compact, comfortable cushion while sitting also helps relieve low back strain.

AB Contour Pillow - Satin Burgundy, Core Products The AB Contour Pillow is designed to provide comfortable support for an aching neck and shoulders. The unique contour shape can support your neck in it's most natural position, helping to relieve cervical strain, tension headaches. Using this compact, comfortable cushion while sitting also helps relieve low back strain.

AB Contour Pillow - Satin White, Core Products The AB Contour Pillow is designed to provide comfortable support for an aching neck and shoulders. The unique contour shape can support your neck in it's most natural position, helping to relieve cervical strain, tension headaches. Using this compact, comfortable cushion while sitting also helps relieve low back strain.

Air Core Pillow, Adjustable, 24 x 16 Inches The popular Tri-Core Pillow is now available with convenient air pump adjustability.

Cervical Pillow, Firm Support, Core Products 22 x 14 x 1/2 Inches This is an exceptional economical foam cervical pillow designed to soothe your neck and back and offer natural support.

Cervical Pillow, Gentle Support, Core Products 22 x 14 x 1/2 Inches This is an exceptional economical foam cervical pillow designed to soothe your neck and back and offer natural support.

Contour Pillow Memory Foam Plus, 4 x 12 x 18.5 Inches, W/ Pillow Cover, 1 Each A variety of conditions such as headaches, neck pain, insomnia, back pain arm and hand numbness can be helped with proper Cervical Spine Support of a Therapeutic pillow.

Core Memory Pillow, Full Size, 14 x 19.5 Inches Molds to the unique shape of your head and neck to provide custom support.

Core Memory Pillow, Mid Size, 12 x 19 Inches Molds to the unique shape of your head and neck to provide custom support.

D Core Pillow Proper cervical support at an economical price.

Double Core Pillow, Medium/Firm Support Choose the level of neck and back support most comfortable for you.

Jungle Print Petite Core Pillow Petite Core Designed With Children in mind. The trapezoid center has been sized to ensure proper support for petites of all ages.

Memory Air-Core Pillow, Core Products By layering premium memory foam atop a therapeutic foam base and adding the adjustability of air, Core has created the perfect orthopedic pillow for memory foam lovers who need greater neck support with adjustable comfort: the Air-Core Memory Pillow.

PowerWrap, Wrist Wrap, Universal, 1 Each Get a custom fit with the PowerWrap every time with our exclusive Positive Tensioning System.

Three Metal Meditation Bracelet This stunning 3 metal bracelet is made for men or women and is hand-made using the following metals: Brass, Silver and Copper.

Wrist & Thumb Spica Splint, Left, Large, Core Products Helps protect wrist and thumb following injury. Helps decrease pain and inflammation from tendinitis. Also helps arthritis. Cotton/polyester construction with soft, cotton liner. Two metal stays support wrist and thumb. Adjustable aluminum wrist support bar.

Wrist & Thumb Spica Splint, Left, Medium, Core Products Helps protect wrist and thumb following injury. Helps decrease pain and inflammation from tendinitis. Also helps arthritis. Cotton/polyester construction with soft, cotton liner. Two metal stays support wrist and thumb. Adjustable aluminum wrist support bar.

Wrist & Thumb Spica Splint, Left, Small, Core Products Helps protect wrist and thumb following injury. Helps decrease pain and inflammation from tendinitis. Also helps arthritis. Cotton/polyester construction with soft, cotton liner. Two metal stays support wrist and thumb. Adjustable aluminum wrist support bar.

Wrist & Thumb Spica Splint, Left, X-Large, Core Products Helps protect wrist and thumb following injury. Helps decrease pain and inflammation from tendinitis. Also helps arthritis. Cotton/polyester construction with soft, cotton liner. Two metal stays support wrist and thumb. Adjustable aluminum wrist support bar.

Wrist & Thumb Spica Splint, Left, X-Small, Core Products Helps protect wrist and thumb following injury. Helps decrease pain and inflammation from tendinitis. Also helps arthritis. Cotton/polyester construction with soft, cotton liner. Two metal stays support wrist and thumb. Adjustable aluminum wrist support bar.

Wrist & Thumb Spica Splint, Right, Large, Core Products Helps protect wrist and thumb following injury. Helps decrease pain and inflammation from tendinitis. Also helps arthritis. Cotton/polyester construction with soft, cotton liner. Two metal stays support wrist and thumb. Adjustable aluminum wrist support bar.

Wrist & Thumb Spica Splint, Right, Medium, Core Products Helps protect wrist and thumb following injury. Helps decrease pain and inflammation from tendinitis. Also helps arthritis. Cotton/polyester construction with soft, cotton liner. Two metal stays support wrist and thumb. Adjustable aluminum wrist support bar.

Wrist & Thumb Spica Splint, Right, Small, Core Products Helps protect wrist and thumb following injury. Helps decrease pain and inflammation from tendinitis. Also helps arthritis. Cotton/polyester construction with soft, cotton liner. Two metal stays support wrist and thumb. Adjustable aluminum wrist support bar.

Wrist & Thumb Spica Splint, Right, X-Large, Core Products Helps protect wrist and thumb following injury. Helps decrease pain and inflammation from tendinitis. Also helps arthritis. Cotton/polyester construction with soft, cotton liner. Two metal stays support wrist and thumb. Adjustable aluminum wrist support bar.

Wrist & Thumb Spica Splint, Right, X-Small, Core Products Helps protect wrist and thumb following injury. Helps decrease pain and inflammation from tendinitis. Also helps arthritis. Cotton/polyester construction with soft, cotton liner. Two metal stays support wrist and thumb. Adjustable aluminum wrist support bar.

Herbal Remedies: Arthritis / Joint Pain / Stiffness Information

Herbal Remedies: Arthritis / Joint Pain / Stiffness Supplements & Products

Herbal Remedies: Rheumatism / Rheumatoid Arthritis Information

Herbal Remedies: Rheumatoid Arthritis Supplements & Products

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LINKS

Scleroderma Foundation

Scleroderma Fact Sheet

International Scleroderma Network (ISN)

Surviving Scleroderma - Support

Scleroderma Research Foundation

I Have Scleroderma

The Scleroderma Society

Scleroderma: ACR Fact Sheets

Juvenile Scleroderma Network

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MOONDRAGON'S RELATED LINKS

MoonDragon's Health & Wellness: Arthritis - Nutrition, Herbal & Supplemental Therapy

MoonDragon's Health & Wellness: Types of Arthritis & Related Disorders

MoonDragon's Health & Wellness: Types of Arthritis - Osteoarthritis (OA)

MoonDragon's Health & Wellness: Types of Arthritis - Rheumatoid Arthritis (RA)

MoonDragon's Health & Wellness: Raynaud's Disease & Phenomenon

MoonDragon's Health & Wellness: Types of Arthritis - Rheumatoid Arthritis (RA)

MoonDragon's Health & Wellness: Fibromyalgia

MoonDragon's Health & Wellness: Hypothyroidism

MoonDragon's Health & Wellness: Heartburn & Acid Reflux

MoonDragon's Health & Wellness: Indigestion

MoonDragon's Health & Wellness: Hypertension

MoonDragon's Health & Wellness: Kidney Disorders

MoonDragon's Health & Wellness: Malabsorption

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HELPFUL PRODUCTS & FURTHER EDUCATION

Prescription for Nutritional Healing: The A-To-Z Guide To Supplements
-- by Phyllis A. Balch, James F. Balch - 2nd Edition

Prescription for Nutritional Healing: The A-To-Z Guide To Supplements
-- by Phyllis A. Balch, James F. Balch - 4th Edition

Prescription for Herbal Healing: The A-To-Z Reference To Common Disorders
-- by Phyllis A. Balch

The Complete Guide to Natural Healing



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